3G1O

EthR from Mycobacterium tuberculosis in complex with compound BDM14500

Summary for 3G1O

Entry DOI	10.2210/pdb3g1o/pdb
Related	1U9N 1U9O 3G1L 3G1M
Descriptor	TRANSCRIPTIONAL REGULATORY REPRESSOR PROTEIN (TETR-FAMILY) ETHR, tert-butyl 4-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate (3 entities in total)
Functional Keywords	tert family; transcriptional repressor, dna-binding, transcription, transcription regulation
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	1
Total formula weight	28314.77
Authors	Willand, N.,Dirie, B.,Carette, X.,Bifani, P.,Singhal, A.,Desroses, M.,Leroux, F.,Willery, E.,Mathys, V.,Deprez-Poulain, R.,Delcroix, G.,Frenois, F.,Aumercier, M.,Locht, C.,Villeret, V.,Deprez, B.,Baulard, A.R. (deposition date: 2009-01-30, release date: 2009-07-21, Last modification date: 2024-02-21)
Primary citation	Willand, N.,Dirie, B.,Carette, X.,Bifani, P.,Singhal, A.,Desroses, M.,Leroux, F.,Willery, E.,Mathys, V.,Deprez-Poulain, R.,Delcroix, G.,Frenois, F.,Aumercier, M.,Locht, C.,Villeret, V.,Deprez, B.,Baulard, A.R. Synthetic EthR inhibitors boost antituberculous activity of ethionamide. NAT.MED. (N.Y.), 15:537-544, 2009 Cited by PubMed: 19412174 DOI: 10.1038/nm.1950 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation