8WMW
| The structure of PSI-11CAC at the stationary growth phase | 分子名称: | (1~{R})-3,5,5-trimethyl-4-[(3~{E},5~{E},7~{E},9~{E},11~{E},13~{E},15~{E})-3,7,12,16-tetramethyl-18-[(4~{R})-2,6,6-trimethyl-4-oxidanyl-cyclohexen-1-yl]octadeca-3,5,7,9,11,13,15-heptaen-1,17-diynyl]cyclohex-3-en-1-ol, (1~{R})-3,5,5-trimethyl-4-[(3~{E},5~{E},7~{E},9~{E},11~{E},13~{E},15~{E},17~{E})-3,7,12,16-tetramethyl-18-(2,6,6-trimethylcyclohexen-1-yl)octadeca-3,5,7,9,11,13,15,17-octaen-1-ynyl]cyclohex-3-en-1-ol, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | 著者 | Zhang, S.M, Si, L, Li, M. | 登録日 | 2023-10-04 | 公開日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Growth phase-dependent reorganization of cryptophyte photosystem I antennae. Commun Biol, 7, 2024
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6WEJ
| Structure of cGMP-unbound WT TAX-4 reconstituted in lipid nanodiscs | 分子名称: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel, ... | 著者 | Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J. | 登録日 | 2020-04-02 | 公開日 | 2020-06-03 | 最終更新日 | 2020-07-22 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel. Nat.Struct.Mol.Biol., 27, 2020
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6WEK
| Structure of cGMP-bound WT TAX-4 reconstituted in lipid nanodiscs | 分子名称: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CYCLIC GUANOSINE MONOPHOSPHATE, ... | 著者 | Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J. | 登録日 | 2020-04-02 | 公開日 | 2020-06-03 | 最終更新日 | 2020-07-22 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel. Nat.Struct.Mol.Biol., 27, 2020
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6WEL
| Structure of cGMP-unbound F403V/V407A mutant TAX-4 reconstituted in lipid nanodiscs | 分子名称: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel, ... | 著者 | Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J. | 登録日 | 2020-04-02 | 公開日 | 2020-06-03 | 最終更新日 | 2020-07-22 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel. Nat.Struct.Mol.Biol., 27, 2020
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7YQF
| Crystal structure of PDE4D complexed with glycyrrhisoflavone | 分子名称: | 1,2-ETHANEDIOL, 3-[3-(3-methylbut-2-enyl)-4,5-bis(oxidanyl)phenyl]-5,7-bis(oxidanyl)chromen-4-one, MAGNESIUM ION, ... | 著者 | Liu, J.Y, Li, M.J, Xu, Y.C. | 登録日 | 2022-08-06 | 公開日 | 2023-07-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19. Proc.Natl.Acad.Sci.USA, 120, 2023
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7YSX
| Crystal structure of PDE4D complexed with licoisoflavone A | 分子名称: | 1,2-ETHANEDIOL, 3-[3-(3-methylbut-2-enyl)-2,4-bis(oxidanyl)phenyl]-5,7-bis(oxidanyl)chromen-4-one, MAGNESIUM ION, ... | 著者 | Liu, J.Y, Li, M.J, Xu, Y.C. | 登録日 | 2022-08-13 | 公開日 | 2023-07-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19. Proc.Natl.Acad.Sci.USA, 120, 2023
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8WNW
| the structure of PsaQ | 分子名称: | 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, CHLOROPHYLL A, PsaQ | 著者 | Zhang, S.M, Si, L, Li, M. | 登録日 | 2023-10-06 | 公開日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Growth phase-dependent reorganization of cryptophyte photosystem I antennae. Commun Biol, 7, 2024
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8W4Q
| Crystal structure of PDE4D complexed with CX-4945 | 分子名称: | 1,2-ETHANEDIOL, 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, MAGNESIUM ION, ... | 著者 | Liu, J.Y, Li, M.J, Xu, Y.C. | 登録日 | 2023-08-24 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors. Eur.J.Med.Chem., 262, 2023
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8W4R
| Crystal structure of PDE4D complexed with CVT-313 | 分子名称: | 1,2-ETHANEDIOL, 2,2'-{[6-{[(4-methoxyphenyl)methyl]amino}-9-(propan-2-yl)-9H-purin-2-yl]azanediyl}di(ethan-1-ol), MAGNESIUM ION, ... | 著者 | Liu, J.Y, Li, M.J, Xu, Y.C. | 登録日 | 2023-08-24 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors. Eur.J.Med.Chem., 262, 2023
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1B11
| STRUCTURE OF FELINE IMMUNODEFICIENCY VIRUS PROTEASE COMPLEXED WITH TL-3-093 | 分子名称: | PROTEIN (Feline Immunodeficiency Virus PROTEASE), SULFATE ION, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate | 著者 | Gustchina, A, Li, M, Wlodawer, A. | 登録日 | 1998-11-25 | 公開日 | 1998-12-02 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease Proteins, 38, 2000
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6IDE
| Crystal structure of the Vibrio cholera VqmA-Ligand-DNA complex provides molecular mechanisms for drug design | 分子名称: | 3,5-dimethylpyrazin-2-ol, DNA (5'-D(*AP*GP*GP*GP*GP*GP*GP*AP*AP*AP*TP*CP*CP*CP*CP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*GP*GP*GP*GP*AP*TP*TP*TP*CP*CP*CP*CP*CP*CP*T)-3'), ... | 著者 | Wu, H, Li, M.J, Guo, H.J, Zhou, H, Li, B, Xu, Q, Xu, C.Y, Yu, F, He, J.H. | 登録日 | 2018-09-09 | 公開日 | 2019-01-16 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Crystal structure of theVibrio choleraeVqmA-ligand-DNA complex provides insight into ligand-binding mechanisms relevant for drug design. J. Biol. Chem., 294, 2019
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4U4F
| Structure of GluA2* in complex with partial agonist (S)-5-Nitrowillardiine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, ... | 著者 | Yelshanskaya, M.V, Li, M, Sobolevsky, A.I. | 登録日 | 2014-07-23 | 公開日 | 2014-08-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (4.79 Å) | 主引用文献 | Structure of an agonist-bound ionotropic glutamate receptor. Science, 345, 2014
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4U4G
| Structure of GluA2* in complex with competitive antagonist ZK 200775 | 分子名称: | Glutamate receptor 2, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid | 著者 | Yelshanskaya, M.V, Li, M, Sobolevsky, A.I. | 登録日 | 2014-07-23 | 公開日 | 2014-10-22 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (4.49 Å) | 主引用文献 | Structure of an agonist-bound ionotropic glutamate receptor. Science, 345, 2014
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8KD3
| Rpd3S in complex with nucleosome with H3K36MLA modification, H3K9Q mutation and 187bp DNA | 分子名称: | 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... | 著者 | Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. | 登録日 | 2023-08-09 | 公開日 | 2023-09-13 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
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8KD2
| Rpd3S in complex with 187bp nucleosome | 分子名称: | 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... | 著者 | Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. | 登録日 | 2023-08-09 | 公開日 | 2023-09-13 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | 主引用文献 | Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
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8KD4
| Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class1 | 分子名称: | 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... | 著者 | Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. | 登録日 | 2023-08-09 | 公開日 | 2023-09-13 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
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8KD5
| Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class2 | 分子名称: | 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... | 著者 | Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Chang, X, Chao, W.C.H, He, J. | 登録日 | 2023-08-09 | 公開日 | 2023-09-13 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
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8KD6
| Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class3 | 分子名称: | 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... | 著者 | Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. | 登録日 | 2023-08-09 | 公開日 | 2023-09-13 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
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8KD7
| Rpd3S in complex with nucleosome with H3K36MLA modification and 167bp DNA | 分子名称: | 167bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... | 著者 | Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Chang, X, Chao, W.C.H, He, J. | 登録日 | 2023-08-09 | 公開日 | 2023-09-13 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
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8W4S
| Crystal structure of PDE5A in complex with CVT-313 | 分子名称: | 2,2'-{[6-{[(4-methoxyphenyl)methyl]amino}-9-(propan-2-yl)-9H-purin-2-yl]azanediyl}di(ethan-1-ol), MAGNESIUM ION, ZINC ION, ... | 著者 | Liu, J.Y, Li, M.J, Xu, Y.C. | 登録日 | 2023-08-24 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.848 Å) | 主引用文献 | Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors. Eur.J.Med.Chem., 262, 2023
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8W4T
| Crystal structure of PDE5A in complex with a novel inhibitor | 分子名称: | 2-[bis(2-hydroxyethyl)amino]-6-[(4-methoxyphenyl)methylamino]-9-propan-2-yl-7~{H}-purin-8-one, MAGNESIUM ION, ZINC ION, ... | 著者 | Liu, J.Y, Li, M.J, Xu, Y.C. | 登録日 | 2023-08-24 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.199 Å) | 主引用文献 | Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors. Eur.J.Med.Chem., 262, 2023
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1AJ4
| STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 1 STRUCTURE | 分子名称: | CALCIUM ION, TROPONIN C | 著者 | Sia, S.K, Li, M.X, Spyracopoulos, L, Gagne, S.M, Liu, W, Putkey, J.A, Sykes, B.D. | 登録日 | 1997-05-14 | 公開日 | 1998-05-20 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain. J.Biol.Chem., 272, 1997
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7QAJ
| ZK002 with Anti-angiogenic and Anti-inflamamtory Properties | 分子名称: | SULFATE ION, Snaclec clone 2100755 alpha, Snaclec clone 2100755 beta | 著者 | Wong, W.Y, Chan, B.D, Muk Lan Lee, M, Dai, X, Tsim, K.W.K, Hsiao, W.L.W, Li, M, Li, X.Y, Tai, W.C.S. | 登録日 | 2021-11-17 | 公開日 | 2023-06-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Isolation and characterization of ZK002, a novel dual function snake venom protein from Deinagkistrodon acutus with anti-angiogenic and anti-inflammatory properties. Front Pharmacol, 14, 2023
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1B8Q
| SOLUTION STRUCTURE OF THE EXTENDED NEURONAL NITRIC OXIDE SYNTHASE PDZ DOMAIN COMPLEXED WITH AN ASSOCIATED PEPTIDE | 分子名称: | PROTEIN (HEPTAPEPTIDE), PROTEIN (NEURONAL NITRIC OXIDE SYNTHASE) | 著者 | Tochio, H, Zhang, Q, Mandal, P, Li, M, Zhang, M. | 登録日 | 1999-02-01 | 公開日 | 1999-04-29 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the extended neuronal nitric oxide synthase PDZ domain complexed with an associated peptide. Nat.Struct.Biol., 6, 1999
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5O9I
| Crystal structure of transcription factor IIB Mvu mini-intein | 分子名称: | Transcription initiation factor IIB,Transcription initiation factor IIB | 著者 | Mikula, K.M, Iwai, H, Li, M, Wlodawer, A. | 登録日 | 2017-06-19 | 公開日 | 2017-11-01 | 最終更新日 | 2022-03-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Basis for the Persistence of Homing Endonucleases in Transcription Factor IIB Inteins. J. Mol. Biol., 429, 2017
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