6IDE

Crystal structure of the Vibrio cholera VqmA-Ligand-DNA complex provides molecular mechanisms for drug design

Summary for 6IDE

• Entry DOI: 10.2210/pdb6ide/pdb
• Descriptor: Transcriptional regulator LuxR family, DNA (5'-D(*AP*GP*GP*GP*GP*GP*GP*AP*AP*AP*TP*CP*CP*CP*CP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*GP*GP*GP*GP*AP*TP*TP*TP*CP*CP*CP*CP*CP*CP*T)-3'), ... (5 entities in total)
• Functional Keywords: vibrio cholera, quorum sensing, transcription regulator, transcription-dna complex, transcription/dna
• Biological source: Vibrio cholerae; More
• Total number of polymer chains: 4
• Total formula weight: 69019.68

Authors

Wu, H.,Li, M.J.,Guo, H.J.,Zhou, H.,Li, B.,Xu, Q.,Xu, C.Y.,Yu, F.,He, J.H. (deposition date: 2018-09-09, release date: 2019-01-16, Last modification date: 2024-03-27)

• Primary citation: Wu, H.,Li, M.,Guo, H.,Zhou, H.,Li, B.,Xu, Q.,Xu, C.,Yu, F.,He, J.; Crystal structure of theVibrio choleraeVqmA-ligand-DNA complex provides insight into ligand-binding mechanisms relevant for drug design.; J. Biol. Chem., 294:2580-2592, 2019; PubMed: 30610119; DOI: 10.1074/jbc.RA118.006082

Experimental method

X-RAY DIFFRACTION (2.51 Å)