8W4R

Crystal structure of PDE4D complexed with CVT-313

Summary for 8W4R

• Entry DOI: 10.2210/pdb8w4r/pdb
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 2,2'-{[6-{[(4-methoxyphenyl)methyl]amino}-9-(propan-2-yl)-9H-purin-2-yl]azanediyl}di(ethan-1-ol), MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: pde4d, complex, inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 81669.63

Authors

Liu, J.Y.,Li, M.J.,Xu, Y.C. (deposition date: 2023-08-24, release date: 2023-11-22)

• Primary citation: Liu, J.,Zhang, X.,Chen, G.,Shao, Q.,Zou, Y.,Li, Z.,Su, H.,Li, M.,Xu, Y.; Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors.; Eur.J.Med.Chem., 262:115893-115893, 2023; PubMed: 37918035; DOI: 10.1016/j.ejmech.2023.115893

Experimental method

X-RAY DIFFRACTION (1.37 Å)