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PDB: 307 件
7F8P
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Crystal structure of the Mycobacterium tuberculosis L,D-transpeptidase-2 (LdtMt2) with new carbapenem drug T203
分子名称: (2R,3R)-3-methyl-4-(2-oxidanylidene-2-propan-2-yloxy-ethyl)sulfanyl-2-[(2R)-3-oxidanyl-1-oxidanylidene-butan-2-yl]-2,3-dihydro-1H-pyrrole-5-carboxylic acid, (4R,5S,6S)-6-((R)-1-hydroxyethyl)-3-((2-isopropoxy-2-oxoethyl)thio)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, GLUTAMIC ACID, ...
著者Kumar, P, Lamichhane, G.
登録日2021-07-02
公開日2022-05-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Allosteric cooperation in beta-lactam binding to a non-classical transpeptidase.
Elife, 11, 2022
7F71
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Crystal structure of the Mycobacterium tuberculosis L,D-transpeptidase-2 (LdtMt2) with peptidoglycan sugar moiety and glutamate
分子名称: GLUTAMIC ACID, GLYCEROL, L,D-transpeptidase 2, ...
著者Kumar, P, Lamichhane, G.
登録日2021-06-26
公開日2022-05-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Allosteric cooperation in beta-lactam binding to a non-classical transpeptidase.
Elife, 11, 2022
4NOF
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Crystal structure of the second Ig domain from mouse Polymeric Immunoglobulin receptor [PSI-NYSGRC-006220]
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Polymeric immunoglobulin receptor
著者Sampathkumar, P, Kumar, P.R, Ahmed, M, Banu, R, Bhosle, R, Calarese, D.A, Celikgil, A, Chamala, S, Chan, M.K, Chowdhury, S, Fiser, A, Garforth, S.J, Glenn, A.S, Hillerich, B, Khafizov, K, Attonito, J, Love, J.D, Patel, H, Patel, R, Seidel, R.D, Smith, B, Stead, M, Casadevall, A, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN)
登録日2013-11-19
公開日2013-12-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of the second Ig domain from mouse Polymeric Immunoglobulin receptor
to be published
3CVL
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Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to T. brucei Phosphofructokinase (PFK) PTS1 peptide
分子名称: Peroxisome targeting signal 1 receptor PEX5, T. brucei PFK PTS1 peptide Ac-HEELAKL
著者Sampathkumar, P, Roach, C, Michels, P.A.M, Hol, W.G.J.
登録日2008-04-18
公開日2008-06-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural Insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.
J.Mol.Biol., 381, 2008
3CVQ
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Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to PTS1 peptide (7-SKL)
分子名称: GLYCEROL, PTS1 peptide 7-SKL (Ac-SNRWSKL), Peroxisome targeting signal 1 receptor PEX5
著者Sampathkumar, P, Roach, C, Michels, P.A.M, Hol, W.G.J.
登録日2008-04-18
公開日2008-06-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Structural Insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.
J.Mol.Biol., 381, 2008
4OO6
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Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1)
分子名称: RNA-binding protein 39, Transportin-1
著者Sampathkumar, P, Brower, A, Soniat, M, Bonanno, J, Hillerich, B, Seidel, R.D, Rout, M.P, Chook, Y.M, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals)
登録日2014-01-30
公開日2014-02-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1)
to be published
6LE1
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Structure of RRM2 domain of DND1 protein
分子名称: Dead end protein homolog 1, GLYCEROL, SULFATE ION
著者Kumari, P, Bhavesh, N.S.
登録日2019-11-23
公開日2020-12-02
最終更新日2021-06-02
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Human DND1-RRM2 forms a non-canonical domain swapped dimer.
Protein Sci., 30, 2021
8EIT
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BU of 8eit by Molmil
Structure of FFAR1-Gq complex bound to DHA
分子名称: A modified Guanine nucleotide-binding protein G(q) subunit alpha, DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 1, ...
著者Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M.
登録日2022-09-15
公開日2023-05-24
最終更新日2023-05-31
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Molecular mechanism of fatty acid activation of FFAR1.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EJK
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Structure of FFAR1-Gq complex bound to TAK-875 in a lipid nanodisc
分子名称: A modified Guanine nucleotide-binding protein G(q) subunit alpha, Free fatty acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M.
登録日2022-09-17
公開日2023-05-24
最終更新日2023-05-31
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Molecular mechanism of fatty acid activation of FFAR1.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EJC
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Structure of FFAR1-Gq complex bound to TAK-875
分子名称: A modified Guanine nucleotide-binding protein G(q) subunit alpha, Free fatty acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M.
登録日2022-09-16
公開日2023-05-24
最終更新日2023-05-31
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Molecular mechanism of fatty acid activation of FFAR1.
Proc.Natl.Acad.Sci.USA, 120, 2023
6FQ3
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Crystal structure of Danio rerio Lin41 filamin-NHL domains in complex with lin-29A 5'UTR 13mer RNA
分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase TRIM71, RNA (5'-R(*GP*GP*AP*GP*UP*CP*CP*AP*AP*CP*UP*CP*C)-3')
著者Kumari, P, Aeschimann, F, Gaidatzis, D, Keusch, J.J, Ghosh, P, Neagu, A, Pachulska-Wieczorek, K, Bujnicki, J.M, Gut, H, Grosshans, H, Ciosk, R.
登録日2018-02-13
公開日2018-05-09
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.901 Å)
主引用文献Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition.
Nat Commun, 9, 2018
6FPT
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Crystal structure of Danio rerio Lin41 filamin-NHL domains
分子名称: E3 ubiquitin-protein ligase TRIM71
著者Kumari, P, Aeschimann, F, Gaidatzis, D, Keusch, J.J, Ghosh, P, Neagu, A, Pachulska-Wieczorek, K, Bujnicki, J.M, Gut, H, Grosshans, H, Ciosk, R.
登録日2018-02-12
公開日2018-05-09
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition.
Nat Commun, 9, 2018
6FQL
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Crystal structure of Danio rerio Lin41 filamin-NHL domains in complex with mab-10 3'UTR 13mer RNA
分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase TRIM71, RNA (5'-R(*UP*GP*CP*AP*UP*UP*UP*AP*AP*UP*GP*CP*A)-3')
著者Kumari, P, Aeschimann, F, Gaidatzis, D, Keusch, J.J, Ghosh, P, Neagu, A, Pachulska-Wieczorek, K, Bujnicki, J.M, Gut, H, Grosshans, H, Ciosk, R.
登録日2018-02-14
公開日2018-05-09
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.349 Å)
主引用文献Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition.
Nat Commun, 9, 2018
6M1X
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BU of 6m1x by Molmil
Crystal structure of Phosphoserine Phosphatase in complex with 3-Phosphoglyceric Acid from Entamoeba histolytica
分子名称: 3-PHOSPHOGLYCERIC ACID, PHOSPHATE ION, Phosphoglycerate mutase family protein
著者Kumari, P, Gourinath, S.
登録日2020-02-26
公開日2021-03-03
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Structural analysis of EhPSP in complex with 3-phosphoglyceric acid from Entamoeba histolytica reveals a basis for its lack of phosphoglycerate mutase activity.
Int.J.Biol.Macromol., 178, 2021
8EX1
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Crystal structure of JAK2 JH2 (pseudokinase domain) in complex with Reversine
分子名称: GLYCEROL, N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine, Tyrosine-protein kinase JAK2
著者Sampathkumar, P, Hubbard, S.R.
登録日2022-10-24
公開日2023-02-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain.
Pharmaceuticals, 16, 2023
8EX0
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Crystal structure of JAK2 JH2 (pseudokinase domain) in complex with CDK2-IV
分子名称: 4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N-diethylbenzamide, Tyrosine-protein kinase JAK2
著者Sampathkumar, P, Hubbard, S.R.
登録日2022-10-24
公開日2023-02-01
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain.
Pharmaceuticals, 16, 2023
8EX2
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Crystal structure of JAK2 JH2 (pseudokinase domain) in complex with HTSA3
分子名称: 3,5-diphenyl-2-(trifluoromethyl)-6~{H}-pyrazolo[1,5-a]pyrimidin-7-one, GLYCEROL, Tyrosine-protein kinase JAK2
著者Sampathkumar, P, Hubbard, S.R.
登録日2022-10-24
公開日2023-02-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain.
Pharmaceuticals, 16, 2023
4IFQ
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Crystal structure of Saccharomyces cerevisiae NUP192, residues 2 to 960 [ScNup192(2-960)]
分子名称: IODIDE ION, Nucleoporin NUP192, SULFATE ION
著者Sampathkumar, P, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals)
登録日2012-12-14
公開日2013-02-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structure, dynamics, evolution, and function of a major scaffold component in the nuclear pore complex.
Structure, 21, 2013
4JLQ
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Crystal structure of human Karyopherin-beta2 bound to the PY-NLS of Saccharomyces cerevisiae NAB2
分子名称: Nuclear polyadenylated RNA-binding protein NAB2, Transportin-1
著者Sampathkumar, P, Gizzi, A, Rout, M.P, Chook, Y.M, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals)
登録日2013-03-12
公開日2013-04-03
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Crystal structure of human Karyopherin beta 2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2.
J.Struct.Funct.Genom., 14, 2013
3H14
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Crystal structure of a putative aminotransferase from Silicibacter pomeroyi
分子名称: Aminotransferase, classes I and II, GLYCEROL
著者Sampathkumar, P, Atwell, S, Wasserman, S, Miller, S, Bain, K, Rutter, M, Tarun, G, Sauder, J.M, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2009-04-10
公開日2009-05-05
最終更新日2021-02-10
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of a putative aminotransferase from Silicibacter pomeroyi
TO BE PUBLISHED
3H9M
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Crystal structure of para-aminobenzoate synthetase, component I from Cytophaga hutchinsonii
分子名称: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, TRIETHYLENE GLYCOL, p-aminobenzoate synthetase, ...
著者Sampathkumar, P, Atwell, S, Wasserman, S, Do, J, Bain, K, Rutter, M, Gheyi, T, Sauder, J.M, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2009-04-30
公開日2009-06-30
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Crystal structure of para-aminobenzoate synthetase, component I from Cytophaga hutchinsonii
To be Published
8TS0
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BU of 8ts0 by Molmil
Crystal Structure of human ASGR1 CRD (Carbohydrate Recognition Domain) bound to 8M24 Fab
分子名称: 8M24 Fab Heavy chain, 8M24 Fab Light chain, Asialoglycoprotein receptor 1, ...
著者Sampathkumar, P, Li, Y.
登録日2023-08-10
公開日2024-06-19
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Targeted protein degradation systems to enhance Wnt signaling.
Elife, 13, 2024
3JTY
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BU of 3jty by Molmil
Crystal structure of a BenF-like porin from Pseudomonas fluorescens Pf-5
分子名称: BenF-like porin, LAURYL DIMETHYLAMINE-N-OXIDE
著者Sampathkumar, P, Lu, F, Zhao, X, Wasserman, S, Iuzuka, M, Bain, K, Rutter, M, Gheyi, T, Atwell, S, Luz, J, Gilmore, J, Sauder, J.M, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2009-09-14
公開日2009-10-20
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Structure of a putative BenF-like porin from Pseudomonas fluorescens Pf-5 at 2.6 A resolution.
Proteins, 78, 2010
3HWJ
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Crystal structure of the second PHR domain of Mouse Myc-binding protein 2 (MYCBP-2)
分子名称: DIMETHYL SULFOXIDE, E3 ubiquitin-protein ligase MYCBP2
著者Sampathkumar, P, Ozyurt, S.A, Wasserman, S.R, Miller, S.A, Bain, K.T, Rutter, M.E, Gheyi, T, Klemke, R.L, Atwell, S, Sauder, J.M, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2009-06-17
公開日2009-07-21
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1.
J.Mol.Biol., 397, 2010
3HQC
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Crystal structure of Phosphotyrosine-binding domain from the Human Tensin-like C1 domain-containing phosphatase (TENC1)
分子名称: ACETATE ION, GLYCEROL, SULFATE ION, ...
著者Sampathkumar, P, Romero, R, Wasserman, S, Do, J, Dickey, M, Bain, K, Gheyi, T, Klemke, R, Atwell, S, Sauder, J.M, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2009-06-05
公開日2009-07-21
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of Phosphotyrosine-binding domain from the Human Tensin-like C1 domain-containing phosphatase (TENC1)
To be Published

224004

件を2024-08-21に公開中

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