1NTP
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3PGF
| Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB) | 分子名称: | GLYCEROL, IMIDAZOLE, Maltose-binding periplasmic protein, ... | 著者 | Kossiakoff, A.A, Duguid, E.M, Sandstrom, A. | 登録日 | 2010-11-01 | 公開日 | 2011-03-09 | 最終更新日 | 2024-11-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins. Nat.Struct.Mol.Biol., 18, 2011
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1TGN
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3BOG
| Snow Flea Antifreeze Protein Quasi-racemate | 分子名称: | 6.5 kDa glycine-rich antifreeze protein, UNKNOWN LIGAND | 著者 | Pentelute, B.L, Kent, S.B.H, Gates, Z.P, Tereshko, V, Kossiakoff, A.A, Kurutz, J, Dashnau, J, Vaderkooi, J.M. | 登録日 | 2007-12-17 | 公開日 | 2008-09-23 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers J.Am.Chem.Soc., 130, 2008
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1HUW
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7RTH
| Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab "NabFab" | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Fragment Antigen-Binding Heavy Chain, ... | 著者 | Filippova, E.V, Mukherjee, S, Bloch, J.S, Locher, K.P, Kossiakoff, A.A. | 登録日 | 2021-08-13 | 公開日 | 2021-09-01 | 最終更新日 | 2024-11-13 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MDJ
| The structure of KcsA in complex with a synthetic Fab | 分子名称: | Fab heavy chain, Fab light chain, POTASSIUM ION, ... | 著者 | Rohaim, A, Slezak, T, Blackowicz, L, Kossiakoff, A, Roux, B. | 登録日 | 2021-04-05 | 公開日 | 2022-02-16 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels. J.Gen.Physiol., 154, 2022
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6USF
| CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor with varenicline in complex with anti-BRIL synthetic antibody BAK5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, ... | 著者 | Alvarez, F.J.D, Mukherjee, S, Han, S, Ammirati, M, Kossiakoff, A.A. | 登録日 | 2019-10-26 | 公開日 | 2020-04-29 | 最終更新日 | 2024-11-13 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins. Nat Commun, 11, 2020
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6UKJ
| Single-Particle Cryo-EM Structure of Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT) 7G8 Isoform | 分子名称: | CHOLESTEROL HEMISUCCINATE, Chloroquine resistance transporter, Fab Heavy Chain, ... | 著者 | Kim, J, Tan, Y.Z, Wicht, K.J, Erramilli, S.K, Dhingra, S.K, Okombo, J, Vendome, J, Hagenah, L.M, Giacometti, S.I, Warren, A.L, Nosol, K, Roepe, P.D, Potter, C.S, Carragher, B, Kossiakoff, A.A, Quick, M, Fidock, D.A, Mancia, F. | 登録日 | 2019-10-05 | 公開日 | 2019-12-04 | 最終更新日 | 2024-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure and drug resistance of the Plasmodium falciparum transporter PfCRT. Nature, 576, 2019
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7MJS
| Single-Particle Cryo-EM Structure of Major Facilitator Superfamily Domain containing 2A in complex with LPC-18:3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2AG3 Fab heavy chain, 2AG3 Fab light chain, ... | 著者 | Cater, R.J, Chua, G.L, Erramilli, S.K, Keener, J.E, Choy, B.C, Tokarz, P, Chin, C.F, Quek, D.Q.Y, Kloss, B, Pepe, J.G, Parisi, G, Wong, B.H, Clarke, O.B, Marty, M.T, Kossiakoff, A.A, Khelashvili, G, Silver, D.L, Mancia, F. | 登録日 | 2021-04-20 | 公開日 | 2021-06-16 | 最終更新日 | 2024-11-13 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Structural basis of omega-3 fatty acid transport across the blood-brain barrier. Nature, 595, 2021
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7M74
| ATP-bound AMP-activated protein kinase | 分子名称: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... | 著者 | Yan, Y, Mukherjee, S, Harikumar, K.G, Strutzenberg, T, Zhou, X.E, Powell, S.K, Xu, T, Sheldon, R, Lamp, J, Brunzelle, J.S, Radziwon, K, Ellis, A, Novick, S.J, Vega, I.E, Jones, R, Miller, L.J, Xu, H.E, Griffin, P.R, Kossiakoff, A.A, Melcher, K. | 登録日 | 2021-03-26 | 公開日 | 2021-12-15 | 最終更新日 | 2024-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.93 Å) | 主引用文献 | Structure of an AMPK complex in an inactive, ATP-bound state. Science, 373, 2021
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3PJS
| Mechanism of Activation Gating in the Full-Length KcsA K+ Channel | 分子名称: | FAB heavy chain, FAB light chain, Voltage-gated potassium channel | 著者 | Uysal, S, Cuello, L.G, Kossiakoff, A, Perozo, E. | 登録日 | 2010-11-10 | 公開日 | 2011-07-06 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Mechanism of activation gating in the full-length KcsA K+ channel. Proc.Natl.Acad.Sci.USA, 108, 2011
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3HHR
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2ARH
| Crystal Structure of a Protein of Unknown Function AQ1966 from Aquifex aeolicus VF5 | 分子名称: | CALCIUM ION, SELENIUM ATOM, SULFATE ION, ... | 著者 | Qiu, Y, Kim, Y, Yang, X, Collart, F, Joachimiak, A, Kossiakoff, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2005-08-19 | 公開日 | 2005-10-04 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Crystal Structure of a Hypothetical Protein Aq_1966 from Aquifex aeolicus VF5 To be Published
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2FD7
| X-ray Crystal Structure of Chemically Synthesized Crambin | 分子名称: | Crambin | 著者 | Bang, D, Tereshko, V, Kossiakoff, A.A, Kent, S.B. | 登録日 | 2005-12-13 | 公開日 | 2007-01-16 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Role of a salt bridge in the model protein crambin explored by chemical protein synthesis: X-ray structure of a unique protein analogue, [V15A]crambin-alpha-carboxamide. Mol Biosyst, 5, 2009
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2FD9
| X-ray Crystal Structure of Chemically Synthesized Crambin-{alpha}carboxamide | 分子名称: | Crambin | 著者 | Bang, D, Tereshko, V, Kossiakoff, A.A, Kent, S.B. | 登録日 | 2005-12-13 | 公開日 | 2007-01-16 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Role of a salt bridge in the model protein crambin explored by chemical protein synthesis: X-ray structure of a unique protein analogue, [V15A]crambin-alpha-carboxamide. Mol Biosyst, 5, 2009
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8SLB
| X-ray structure of CorA N-terminal domain in complex with conformation-specific synthetic antibody C12 | 分子名称: | CHLORIDE ION, Cobalt/magnesium transport protein CorA, sAB C12 Heavy Chain, ... | 著者 | Dominik, P.K, Erramilli, S.K, Reddy, B.G, Kossiakoff, A.A. | 登録日 | 2023-04-21 | 公開日 | 2023-06-07 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Conformation-specific Synthetic Antibodies Discriminate Multiple Functional States of the Ion Channel CorA. J.Mol.Biol., 435, 2023
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6UR8
| CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with varenicline | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Chimera of soluble cytochrome b562 (BRIL) and neuronal acetylcholine receptor subunit alpha-4, Neuronal acetylcholine receptor subunit beta-2, ... | 著者 | Alvarez, F.J.D, Mukherjee, S, Han, S, Ammirati, M, Kossiakoff, A.A. | 登録日 | 2019-10-22 | 公開日 | 2020-04-29 | 最終更新日 | 2024-11-13 | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | 主引用文献 | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins. Nat Commun, 11, 2020
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2FCQ
| X-ray Crystal Structure of a Chemically Synthesized Ubiquitin with a Cubic Space Group | 分子名称: | CADMIUM ION, Ubiquitin | 著者 | Bang, D, Gribenko, A.V, Tereshko, V, Kossiakoff, A.A, Kent, S.B, Makhatadze, G.I. | 登録日 | 2005-12-12 | 公開日 | 2006-01-31 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis. Nat.Chem.Biol., 2, 2006
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2FCM
| X-ray Crystal Structure of a Chemically Synthesized [D-Gln35]Ubiquitin with a Cubic Space Group | 分子名称: | ACETATE ION, CADMIUM ION, Ubiquitin | 著者 | Bang, D, Gribenko, A.V, Tereshko, V, Kossiakoff, A.A, Kent, S.B, Makhatadze, G.I. | 登録日 | 2005-12-12 | 公開日 | 2006-01-31 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis. Nat.Chem.Biol., 2, 2006
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2FCS
| X-ray Crystal Structure of a Chemically Synthesized [L-Gln35]Ubiquitin with a Cubic Space Group | 分子名称: | ACETATE ION, CADMIUM ION, SULFATE ION, ... | 著者 | Bang, D, Gribenko, A.V, Tereshko, V, Kossiakoff, A.A, Kent, S.B, Makhatadze, G.I. | 登録日 | 2005-12-12 | 公開日 | 2006-01-31 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis. Nat.Chem.Biol., 2, 2006
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2FCN
| X-ray Crystal Structure of a Chemically Synthesized [D-Val35]Ubiquitin with a Cubic Space Group | 分子名称: | ACETATE ION, CADMIUM ION, Ubiquitin | 著者 | Bang, D, Gribenko, A.V, Tereshko, V, Kossiakoff, A.A, Kent, S.B, Makhatadze, G.I. | 登録日 | 2005-12-12 | 公開日 | 2006-01-31 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis. Nat.Chem.Biol., 2, 2006
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7KEO
| Crystal structure of K29-linked di-ubiquitin in complex with synthetic antigen binding fragment | 分子名称: | PHOSPHATE ION, Synthetic antigen binding fragment, heavy chain, ... | 著者 | Yu, Y, Zheng, Q, Erramilli, S, Pan, M, Kossiakoff, A, Liu, L, Zhao, M. | 登録日 | 2020-10-11 | 公開日 | 2021-07-28 | 最終更新日 | 2024-11-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle. Nat.Chem.Biol., 17, 2021
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8THE
| Cryo-EM structure of Pseudomonas aeruginosa TonB-dependent transporter PhuR in complex with synthetic antibody and heme | 分子名称: | (2~{R},4~{R},5~{S},6~{S})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[[(2~{R},3~{S},4~{S},5~{R},6~{S})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{R},4~{R},5~{S},6~{S})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{S})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-4,5-bis(oxidanyl)oxane-2-carboxylic acid, Heme/hemoglobin uptake outer membrane receptor PhuR, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Knejski, P, Erramilli, S.K, Kossiakoff, A.A. | 登録日 | 2023-07-15 | 公開日 | 2024-01-31 | 最終更新日 | 2024-11-13 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme binding. Structure, 32, 2024
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8T58
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