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PDB: 162 件

1NTP
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BU of 1ntp by Molmil
USE OF THE NEUTRON DIFFRACTION H/D EXCHANGE TECHNIQUE TO DETERMINE THE CONFORMATIONAL DYNAMICS OF TRYPSIN
分子名称: BETA-TRYPSIN, PHOSPHORYLISOPROPANE
著者Kossiakoff, A.A.
登録日1987-09-16
公開日1988-01-16
最終更新日2024-10-30
実験手法NEUTRON DIFFRACTION (1.8 Å)
主引用文献Use of the neutron diffraction--H/D exchange technique to determine the conformational dynamics of trypsin
Basic Life Sci., 27, 1984
3PGF
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BU of 3pgf by Molmil
Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB)
分子名称: GLYCEROL, IMIDAZOLE, Maltose-binding periplasmic protein, ...
著者Kossiakoff, A.A, Duguid, E.M, Sandstrom, A.
登録日2010-11-01
公開日2011-03-09
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins.
Nat.Struct.Mol.Biol., 18, 2011
1TGN
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BU of 1tgn by Molmil
STRUCTURE OF BOVINE TRYPSINOGEN AT 1.9 ANGSTROMS RESOLUTION
分子名称: TRYPSINOGEN
著者Kossiakoff, A.A, Stroud, R.M.
登録日1979-09-19
公開日1979-10-19
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structure of bovine trypsinogen at 1.9 A resolution.
Biochemistry, 16, 1977
3BOG
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BU of 3bog by Molmil
Snow Flea Antifreeze Protein Quasi-racemate
分子名称: 6.5 kDa glycine-rich antifreeze protein, UNKNOWN LIGAND
著者Pentelute, B.L, Kent, S.B.H, Gates, Z.P, Tereshko, V, Kossiakoff, A.A, Kurutz, J, Dashnau, J, Vaderkooi, J.M.
登録日2007-12-17
公開日2008-09-23
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers
J.Am.Chem.Soc., 130, 2008
1HUW
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BU of 1huw by Molmil
THE CRYSTAL STRUCTURE OF AFFINITY-MATURED HUMAN GROWTH HORMONE AT 2 ANGSTROMS RESOLUTION
分子名称: HUMAN GROWTH HORMONE
著者Ultsch, M.H, Somers, W.S, Kossiakoff, A.A, De Vos, A.M.
登録日1993-09-22
公開日1994-01-31
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of affinity-matured human growth hormone at 2 A resolution.
J.Mol.Biol., 236, 1994
7RTH
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BU of 7rth by Molmil
Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab "NabFab"
分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Fragment Antigen-Binding Heavy Chain, ...
著者Filippova, E.V, Mukherjee, S, Bloch, J.S, Locher, K.P, Kossiakoff, A.A.
登録日2021-08-13
公開日2021-09-01
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MDJ
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BU of 7mdj by Molmil
The structure of KcsA in complex with a synthetic Fab
分子名称: Fab heavy chain, Fab light chain, POTASSIUM ION, ...
著者Rohaim, A, Slezak, T, Blackowicz, L, Kossiakoff, A, Roux, B.
登録日2021-04-05
公開日2022-02-16
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels.
J.Gen.Physiol., 154, 2022
6USF
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BU of 6usf by Molmil
CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor with varenicline in complex with anti-BRIL synthetic antibody BAK5
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, ...
著者Alvarez, F.J.D, Mukherjee, S, Han, S, Ammirati, M, Kossiakoff, A.A.
登録日2019-10-26
公開日2020-04-29
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (3.87 Å)
主引用文献Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
Nat Commun, 11, 2020
6UKJ
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Single-Particle Cryo-EM Structure of Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT) 7G8 Isoform
分子名称: CHOLESTEROL HEMISUCCINATE, Chloroquine resistance transporter, Fab Heavy Chain, ...
著者Kim, J, Tan, Y.Z, Wicht, K.J, Erramilli, S.K, Dhingra, S.K, Okombo, J, Vendome, J, Hagenah, L.M, Giacometti, S.I, Warren, A.L, Nosol, K, Roepe, P.D, Potter, C.S, Carragher, B, Kossiakoff, A.A, Quick, M, Fidock, D.A, Mancia, F.
登録日2019-10-05
公開日2019-12-04
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.
Nature, 576, 2019
7MJS
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BU of 7mjs by Molmil
Single-Particle Cryo-EM Structure of Major Facilitator Superfamily Domain containing 2A in complex with LPC-18:3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2AG3 Fab heavy chain, 2AG3 Fab light chain, ...
著者Cater, R.J, Chua, G.L, Erramilli, S.K, Keener, J.E, Choy, B.C, Tokarz, P, Chin, C.F, Quek, D.Q.Y, Kloss, B, Pepe, J.G, Parisi, G, Wong, B.H, Clarke, O.B, Marty, M.T, Kossiakoff, A.A, Khelashvili, G, Silver, D.L, Mancia, F.
登録日2021-04-20
公開日2021-06-16
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (3.03 Å)
主引用文献Structural basis of omega-3 fatty acid transport across the blood-brain barrier.
Nature, 595, 2021
7M74
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ATP-bound AMP-activated protein kinase
分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Yan, Y, Mukherjee, S, Harikumar, K.G, Strutzenberg, T, Zhou, X.E, Powell, S.K, Xu, T, Sheldon, R, Lamp, J, Brunzelle, J.S, Radziwon, K, Ellis, A, Novick, S.J, Vega, I.E, Jones, R, Miller, L.J, Xu, H.E, Griffin, P.R, Kossiakoff, A.A, Melcher, K.
登録日2021-03-26
公開日2021-12-15
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (3.93 Å)
主引用文献Structure of an AMPK complex in an inactive, ATP-bound state.
Science, 373, 2021
3PJS
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BU of 3pjs by Molmil
Mechanism of Activation Gating in the Full-Length KcsA K+ Channel
分子名称: FAB heavy chain, FAB light chain, Voltage-gated potassium channel
著者Uysal, S, Cuello, L.G, Kossiakoff, A, Perozo, E.
登録日2010-11-10
公開日2011-07-06
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Mechanism of activation gating in the full-length KcsA K+ channel.
Proc.Natl.Acad.Sci.USA, 108, 2011
3HHR
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BU of 3hhr by Molmil
HUMAN GROWTH HORMONE AND EXTRACELLULAR DOMAIN OF ITS RECEPTOR: CRYSTAL STRUCTURE OF THE COMPLEX
分子名称: HUMAN GROWTH HORMONE, HUMAN GROWTH HORMONE RECEPTOR (hGHbp)
著者De Vos, A.M, Ultsch, M, Kossiakoff, A.A.
登録日1993-12-30
公開日1994-04-30
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
Science, 255, 1992
2ARH
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BU of 2arh by Molmil
Crystal Structure of a Protein of Unknown Function AQ1966 from Aquifex aeolicus VF5
分子名称: CALCIUM ION, SELENIUM ATOM, SULFATE ION, ...
著者Qiu, Y, Kim, Y, Yang, X, Collart, F, Joachimiak, A, Kossiakoff, A, Midwest Center for Structural Genomics (MCSG)
登録日2005-08-19
公開日2005-10-04
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Crystal Structure of a Hypothetical Protein Aq_1966 from Aquifex aeolicus VF5
To be Published
2FD7
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BU of 2fd7 by Molmil
X-ray Crystal Structure of Chemically Synthesized Crambin
分子名称: Crambin
著者Bang, D, Tereshko, V, Kossiakoff, A.A, Kent, S.B.
登録日2005-12-13
公開日2007-01-16
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Role of a salt bridge in the model protein crambin explored by chemical protein synthesis: X-ray structure of a unique protein analogue, [V15A]crambin-alpha-carboxamide.
Mol Biosyst, 5, 2009
2FD9
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BU of 2fd9 by Molmil
X-ray Crystal Structure of Chemically Synthesized Crambin-{alpha}carboxamide
分子名称: Crambin
著者Bang, D, Tereshko, V, Kossiakoff, A.A, Kent, S.B.
登録日2005-12-13
公開日2007-01-16
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Role of a salt bridge in the model protein crambin explored by chemical protein synthesis: X-ray structure of a unique protein analogue, [V15A]crambin-alpha-carboxamide.
Mol Biosyst, 5, 2009
8SLB
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BU of 8slb by Molmil
X-ray structure of CorA N-terminal domain in complex with conformation-specific synthetic antibody C12
分子名称: CHLORIDE ION, Cobalt/magnesium transport protein CorA, sAB C12 Heavy Chain, ...
著者Dominik, P.K, Erramilli, S.K, Reddy, B.G, Kossiakoff, A.A.
登録日2023-04-21
公開日2023-06-07
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Conformation-specific Synthetic Antibodies Discriminate Multiple Functional States of the Ion Channel CorA.
J.Mol.Biol., 435, 2023
6UR8
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BU of 6ur8 by Molmil
CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with varenicline
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Chimera of soluble cytochrome b562 (BRIL) and neuronal acetylcholine receptor subunit alpha-4, Neuronal acetylcholine receptor subunit beta-2, ...
著者Alvarez, F.J.D, Mukherjee, S, Han, S, Ammirati, M, Kossiakoff, A.A.
登録日2019-10-22
公開日2020-04-29
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (3.71 Å)
主引用文献Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
Nat Commun, 11, 2020
2FCQ
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X-ray Crystal Structure of a Chemically Synthesized Ubiquitin with a Cubic Space Group
分子名称: CADMIUM ION, Ubiquitin
著者Bang, D, Gribenko, A.V, Tereshko, V, Kossiakoff, A.A, Kent, S.B, Makhatadze, G.I.
登録日2005-12-12
公開日2006-01-31
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis.
Nat.Chem.Biol., 2, 2006
2FCM
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BU of 2fcm by Molmil
X-ray Crystal Structure of a Chemically Synthesized [D-Gln35]Ubiquitin with a Cubic Space Group
分子名称: ACETATE ION, CADMIUM ION, Ubiquitin
著者Bang, D, Gribenko, A.V, Tereshko, V, Kossiakoff, A.A, Kent, S.B, Makhatadze, G.I.
登録日2005-12-12
公開日2006-01-31
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis.
Nat.Chem.Biol., 2, 2006
2FCS
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BU of 2fcs by Molmil
X-ray Crystal Structure of a Chemically Synthesized [L-Gln35]Ubiquitin with a Cubic Space Group
分子名称: ACETATE ION, CADMIUM ION, SULFATE ION, ...
著者Bang, D, Gribenko, A.V, Tereshko, V, Kossiakoff, A.A, Kent, S.B, Makhatadze, G.I.
登録日2005-12-12
公開日2006-01-31
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis.
Nat.Chem.Biol., 2, 2006
2FCN
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X-ray Crystal Structure of a Chemically Synthesized [D-Val35]Ubiquitin with a Cubic Space Group
分子名称: ACETATE ION, CADMIUM ION, Ubiquitin
著者Bang, D, Gribenko, A.V, Tereshko, V, Kossiakoff, A.A, Kent, S.B, Makhatadze, G.I.
登録日2005-12-12
公開日2006-01-31
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis.
Nat.Chem.Biol., 2, 2006
7KEO
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BU of 7keo by Molmil
Crystal structure of K29-linked di-ubiquitin in complex with synthetic antigen binding fragment
分子名称: PHOSPHATE ION, Synthetic antigen binding fragment, heavy chain, ...
著者Yu, Y, Zheng, Q, Erramilli, S, Pan, M, Kossiakoff, A, Liu, L, Zhao, M.
登録日2020-10-11
公開日2021-07-28
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.
Nat.Chem.Biol., 17, 2021
8THE
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BU of 8the by Molmil
Cryo-EM structure of Pseudomonas aeruginosa TonB-dependent transporter PhuR in complex with synthetic antibody and heme
分子名称: (2~{R},4~{R},5~{S},6~{S})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[[(2~{R},3~{S},4~{S},5~{R},6~{S})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{R},4~{R},5~{S},6~{S})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{S})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-4,5-bis(oxidanyl)oxane-2-carboxylic acid, Heme/hemoglobin uptake outer membrane receptor PhuR, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Knejski, P, Erramilli, S.K, Kossiakoff, A.A.
登録日2023-07-15
公開日2024-01-31
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme binding.
Structure, 32, 2024
8T58
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Structure of VHH-Fab complex with engineered FNQIKG elbow region
分子名称: CHLORIDE ION, Fab heavy chain, Fab light chain, ...
著者Filippova, E.V, Kossiakoff, A.A.
登録日2023-06-12
公開日2023-11-29
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
Protein Sci., 33, 2024

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