1NTP
 
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3PGF
 | | Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB) | | 分子名称: | GLYCEROL, IMIDAZOLE, Maltose-binding periplasmic protein, ... | | 著者 | Kossiakoff, A.A, Duguid, E.M, Sandstrom, A. | | 登録日 | 2010-11-01 | | 公開日 | 2011-03-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins.
Nat.Struct.Mol.Biol., 18, 2011
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1TGN
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3BOG
 | | Snow Flea Antifreeze Protein Quasi-racemate | | 分子名称: | 6.5 kDa glycine-rich antifreeze protein, UNKNOWN LIGAND | | 著者 | Pentelute, B.L, Kent, S.B.H, Gates, Z.P, Tereshko, V, Kossiakoff, A.A, Kurutz, J, Dashnau, J, Vaderkooi, J.M. | | 登録日 | 2007-12-17 | | 公開日 | 2008-09-23 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers
J.Am.Chem.Soc., 130, 2008
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1HUW
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7MJS
 | | Single-Particle Cryo-EM Structure of Major Facilitator Superfamily Domain containing 2A in complex with LPC-18:3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2AG3 Fab heavy chain, 2AG3 Fab light chain, ... | | 著者 | Cater, R.J, Chua, G.L, Erramilli, S.K, Keener, J.E, Choy, B.C, Tokarz, P, Chin, C.F, Quek, D.Q.Y, Kloss, B, Pepe, J.G, Parisi, G, Wong, B.H, Clarke, O.B, Marty, M.T, Kossiakoff, A.A, Khelashvili, G, Silver, D.L, Mancia, F. | | 登録日 | 2021-04-20 | | 公開日 | 2021-06-16 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | Structural basis of omega-3 fatty acid transport across the blood-brain barrier.
Nature, 595, 2021
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6UKJ
 | | Single-Particle Cryo-EM Structure of Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT) 7G8 Isoform | | 分子名称: | CHOLESTEROL HEMISUCCINATE, Chloroquine resistance transporter, Fab Heavy Chain, ... | | 著者 | Kim, J, Tan, Y.Z, Wicht, K.J, Erramilli, S.K, Dhingra, S.K, Okombo, J, Vendome, J, Hagenah, L.M, Giacometti, S.I, Warren, A.L, Nosol, K, Roepe, P.D, Potter, C.S, Carragher, B, Kossiakoff, A.A, Quick, M, Fidock, D.A, Mancia, F. | | 登録日 | 2019-10-05 | | 公開日 | 2019-12-04 | | 最終更新日 | 2020-01-08 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.
Nature, 576, 2019
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6U8C
 | | Crystal structure of an engineered ultra-high affinity Fab-Protein G complex | | 分子名称: | Antibody heavy chain Fab, Antibody light chain Fab, Protein G | | 著者 | Slezak, T, Filippova, E.V, Davydova, E.K, Kossiakoff, A.A. | | 登録日 | 2019-09-04 | | 公開日 | 2019-10-23 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | An engineered ultra-high affinity Fab-Protein G pair enables a modular antibody platform with multifunctional capability.
Protein Sci., 29, 2020
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3PJS
 | | Mechanism of Activation Gating in the Full-Length KcsA K+ Channel | | 分子名称: | FAB heavy chain, FAB light chain, Voltage-gated potassium channel | | 著者 | Uysal, S, Cuello, L.G, Kossiakoff, A, Perozo, E. | | 登録日 | 2010-11-10 | | 公開日 | 2011-07-06 | | 最終更新日 | 2011-08-03 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Mechanism of activation gating in the full-length KcsA K+ channel.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3HHR
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7KEO
 | | Crystal structure of K29-linked di-ubiquitin in complex with synthetic antigen binding fragment | | 分子名称: | PHOSPHATE ION, Synthetic antigen binding fragment, heavy chain, ... | | 著者 | Yu, Y, Zheng, Q, Erramilli, S, Pan, M, Kossiakoff, A, Liu, L, Zhao, M. | | 登録日 | 2020-10-11 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.
Nat.Chem.Biol., 17, 2021
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1KF9
 | | PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR | | 分子名称: | EXTRACELLULAR DOMAIN HUMAN GROWTH HORMONE RECEPTOR (1-238), PHAGE DISPLAY DERIVED VARIANT HUMAN GROWTH HORMONE | | 著者 | Schiffer, C.A, Ultsch, M, Walsh, S, Somers, W, De Vos, A.M, Kossiakoff, A.A. | | 登録日 | 2001-11-19 | | 公開日 | 2002-11-20 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of a Phage Display Derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of its Receptor: Evidence for Strong Structural Coupling between Receptor Binding Sites
J.Mol.Biol., 316, 2002
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6USF
 | | CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor with varenicline in complex with anti-BRIL synthetic antibody BAK5 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, ... | | 著者 | Alvarez, F.J.D, Mukherjee, S, Han, S, Ammirati, M, Kossiakoff, A.A. | | 登録日 | 2019-10-26 | | 公開日 | 2020-04-29 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | | 主引用文献 | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
Nat Commun, 11, 2020
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6UR8
 | | CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with varenicline | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Chimera of soluble cytochrome b562 (BRIL) and neuronal acetylcholine receptor subunit alpha-4, Neuronal acetylcholine receptor subunit beta-2, ... | | 著者 | Alvarez, F.J.D, Mukherjee, S, Han, S, Ammirati, M, Kossiakoff, A.A. | | 登録日 | 2019-10-22 | | 公開日 | 2020-04-29 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | | 主引用文献 | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
Nat Commun, 11, 2020
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6SNI
 | | Cryo-EM structure of nanodisc reconstituted yeast ALG6 in complex with 6AG9 Fab | | 分子名称: | 6AG9-Fab heavy chain, 6AG9-Fab light chain, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Bloch, J.S, Pesciullesi, G, Boilevin, J, Nosol, K, Irobalieva, R.N, Darbre, T, Aebi, M, Kossiakoff, A.A, Reymond, J.L, Locher, K.P. | | 登録日 | 2019-08-24 | | 公開日 | 2020-03-11 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure and mechanism of the ER-based glucosyltransferase ALG6.
Nature, 579, 2020
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6SNH
 | | Cryo-EM structure of yeast ALG6 in complex with 6AG9 Fab and Dol25-P-Glc | | 分子名称: | 6AG9 Fab heavy chain, 6AG9 Fab light chain, Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase, ... | | 著者 | Bloch, J.S, Pesciullesi, G, Boilevin, J, Nosol, K, Irobalieva, R.N, Darbre, T, Aebi, M, Kossiakoff, A.A, Reymond, J.L, Locher, K.P. | | 登録日 | 2019-08-24 | | 公開日 | 2020-03-11 | | 最終更新日 | 2020-04-01 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structure and mechanism of the ER-based glucosyltransferase ALG6.
Nature, 579, 2020
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6RLX
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7PHP
 | | Structure of Multidrug and Toxin Compound Extrusion (MATE) transporter NorM by NabFab-fiducial assisted cryo-EM | | 分子名称: | Anti-Fab nanobody, Multidrug resistance protein NorM, NabFab HC, ... | | 著者 | Bloch, J.S, Mukherjee, S, Kowal, J, Niederer, M, Pardon, E, Steyaert, J, Kossiakoff, A.A, Locher, K.P. | | 登録日 | 2021-08-18 | | 公開日 | 2021-09-01 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | | 主引用文献 | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7PIJ
 | | Structure of Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM | | 分子名称: | Anti-Fab nanobody, DMTNb16_4, Divalent metal cation transporter MntH, ... | | 著者 | Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P. | | 登録日 | 2021-08-20 | | 公開日 | 2021-09-01 | | 最終更新日 | 2021-12-01 | | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | | 主引用文献 | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7PHQ
 | | Structure of homo-dimeric Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM | | 分子名称: | Anti-Fab nanobody, DMT-Nb16_4, Divalent metal cation transporter MntH, ... | | 著者 | Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P. | | 登録日 | 2021-08-18 | | 公開日 | 2021-09-01 | | 最終更新日 | 2021-12-01 | | 実験手法 | ELECTRON MICROSCOPY (8.45 Å) | | 主引用文献 | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7ZYI
 | | Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody | | 分子名称: | CHOLESTEROL, GLYCOCHENODEOXYCHOLIC ACID, Nanobody, ... | | 著者 | Liu, H, Irobalieva, R.N, Bang-Sorensen, R, Nosol, K, Mukherjee, S, Agrawal, P, Stieger, B, Kossiakoff, A.A, Locher, K.P. | | 登録日 | 2022-05-24 | | 公開日 | 2022-07-13 | | 最終更新日 | 2022-08-10 | | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | | 主引用文献 | Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.
Cell Res., 32, 2022
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5BK1
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6AZ2
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6AYZ
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2R8S
 | | High resolution structure of a specific synthetic FAB bound to P4-P6 RNA ribozyme domain | | 分子名称: | Fab heavy chain, Fab light chain, MAGNESIUM ION, ... | | 著者 | Ye, J.D, Tereshko, V, Sidhu, S.S, Koide, S, Kossiakoff, A.A, Piccirilli, J.A. | | 登録日 | 2007-09-11 | | 公開日 | 2007-12-04 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Synthetic antibodies for specific recognition and crystallization of structured RNA
Proc.Natl.Acad.Sci.Usa, 105, 2008
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