7ZYI

Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody

Summary for 7ZYI

• Entry DOI: 10.2210/pdb7zyi/pdb
• EMDB information: 15024
• Descriptor: Sodium/bile acid cotransporter, heavy chain of Fab, light chain of Fab, ... (8 entities in total)
• Functional Keywords: ntcp, membrane protein, transport, sodium/bile acid cotransporter, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 101987.36

Authors

Liu, H.,Irobalieva, R.N.,Bang-Sorensen, R.,Nosol, K.,Mukherjee, S.,Agrawal, P.,Stieger, B.,Kossiakoff, A.A.,Locher, K.P. (deposition date: 2022-05-24, release date: 2022-07-13, Last modification date: 2024-11-13)

• Primary citation: Liu, H.,Irobalieva, R.N.,Bang-Sorensen, R.,Nosol, K.,Mukherjee, S.,Agrawal, P.,Stieger, B.,Kossiakoff, A.A.,Locher, K.P.; Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.; Cell Res., 32:773-776, 2022; PubMed: 35726088; DOI: 10.1038/s41422-022-00680-4

Experimental method

ELECTRON MICROSCOPY (2.88 Å)