7ZYI
Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody
Summary for 7ZYI
Entry DOI | 10.2210/pdb7zyi/pdb |
EMDB information | 15024 |
Descriptor | Sodium/bile acid cotransporter, heavy chain of Fab, light chain of Fab, ... (8 entities in total) |
Functional Keywords | ntcp, membrane protein, transport, sodium/bile acid cotransporter, transport protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 101987.36 |
Authors | Liu, H.,Irobalieva, R.N.,Bang-Sorensen, R.,Nosol, K.,Mukherjee, S.,Agrawal, P.,Stieger, B.,Kossiakoff, A.A.,Locher, K.P. (deposition date: 2022-05-24, release date: 2022-07-13, Last modification date: 2022-08-10) |
Primary citation | Liu, H.,Irobalieva, R.N.,Bang-Sorensen, R.,Nosol, K.,Mukherjee, S.,Agrawal, P.,Stieger, B.,Kossiakoff, A.A.,Locher, K.P. Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver. Cell Res., 32:773-776, 2022 Cited by PubMed: 35726088DOI: 10.1038/s41422-022-00680-4 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.88 Å) |
Structure validation
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