7ZYI
Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium/bile acid cotransporter | polymer | 349 | 38149.9 | 1 | UniProt (Q14973) Pfam (PF01758) | Homo sapiens (human) | Cell growth-inhibiting gene 29 protein,Na(+)/bile acid cotransporter,Na(+)/taurocholate transport protein,Sodium/taurocholate cotransporting polypeptide,Solute carrier family 10 member 1 |
| 2 | B (H) | heavy chain of Fab | polymer | 238 | 25582.5 | 1 | Mus musculus | ||
| 3 | C (L) | light chain of Fab | polymer | 215 | 23418.0 | 1 | Mus musculus | ||
| 4 | D (K) | Nanobody | polymer | 120 | 13118.4 | 1 | Lama glama | ||
| 5 | E, H (A) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) | |||
| 6 | F, G (A) | GLYCOCHENODEOXYCHOLIC ACID | non-polymer | 449.6 | 2 | Chemie (CHO) | |||
| 7 | I, J (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 8 | K (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 100268.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1718.5 | |
| All* | Total formula weight | 101987.4 |
