2BNH
| PORCINE RIBONUCLEASE INHIBITOR | Descriptor: | RIBONUCLEASE INHIBITOR | Authors: | Kobe, B, Deisenhofer, J. | Deposit date: | 1996-06-29 | Release date: | 1997-03-12 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mechanism of ribonuclease inhibition by ribonuclease inhibitor protein based on the crystal structure of its complex with ribonuclease A. J.Mol.Biol., 264, 1996
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1DFJ
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1PHZ
| STRUCTURE OF PHOSPHORYLATED PHENYLALANINE HYDROXYLASE | Descriptor: | FE (III) ION, PROTEIN (PHENYLALANINE HYDROXYLASE) | Authors: | Kobe, B, Jennings, I.G, House, C.M, Michell, B.J, Cotton, R.G, Kemp, B.E. | Deposit date: | 1998-11-11 | Release date: | 1999-04-30 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of autoregulation of phenylalanine hydroxylase. Nat.Struct.Biol., 6, 1999
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2PHM
| STRUCTURE OF PHENYLALANINE HYDROXYLASE DEPHOSPHORYLATED | Descriptor: | FE (III) ION, PROTEIN (PHENYLALANINE-4-HYDROXYLASE) | Authors: | Kobe, B, Jennings, I.G, House, C.M, Michell, B.J, Cotton, R.G, Kemp, B.E. | Deposit date: | 1998-11-11 | Release date: | 1999-04-30 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of autoregulation of phenylalanine hydroxylase. Nat.Struct.Biol., 6, 1999
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1KOB
| TWITCHIN KINASE FRAGMENT (APLYSIA), AUTOREGULATED PROTEIN KINASE DOMAIN | Descriptor: | TWITCHIN, VALINE | Authors: | Kobe, B, Heierhorst, J, Feil, S.C, Parker, M.W, Benian, G.M, Weiss, K.R, Kemp, B.E. | Deposit date: | 1996-06-28 | Release date: | 1997-03-12 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Giant protein kinases: domain interactions and structural basis of autoregulation. EMBO J., 15, 1996
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1KOA
| TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS | Descriptor: | TWITCHIN | Authors: | Kobe, B, Heierhorst, J, Feil, S.C, Parker, M.W, Benian, G.M, Weiss, K.R, Kemp, B.E. | Deposit date: | 1996-06-28 | Release date: | 1997-03-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Giant protein kinases: domain interactions and structural basis of autoregulation. EMBO J., 15, 1996
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1MG1
| HTLV-1 GP21 ECTODOMAIN/MALTOSE-BINDING PROTEIN CHIMERA | Descriptor: | CHLORIDE ION, PROTEIN (HTLV-1 GP21 ECTODOMAIN/MALTOSE-BINDING PROTEIN CHIMERA), alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Kobe, B, Center, R.J, Kemp, B.E, Poumbourios, P. | Deposit date: | 1999-03-01 | Release date: | 1999-04-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteins. Proc.Natl.Acad.Sci.USA, 96, 1999
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1IAL
| IMPORTIN ALPHA, MOUSE | Descriptor: | IMPORTIN ALPHA | Authors: | Kobe, B. | Deposit date: | 1999-01-12 | Release date: | 1999-06-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha. Nat.Struct.Biol., 6, 1999
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1EJL
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4ZM1
| Shigella flexneri lipopolysaccharide O-antigen chain-length regulator WzzBSF - wild type | Descriptor: | CITRIC ACID, Chain length determinant protein, MAGNESIUM ION | Authors: | Ericsson, D.J, Chang, C.-W, Lonhienne, T, Casey, L, Benning, F, Kobe, B, Tran, E.N.H, Morona, R. | Deposit date: | 2015-05-02 | Release date: | 2016-03-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural and Biochemical Analysis of a Single Amino-Acid Mutant of WzzBSF That Alters Lipopolysaccharide O-Antigen Chain Length in Shigella flexneri. Plos One, 10, 2015
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4UTP
| Crystal structure of pneumococcal surface antigen PsaA in the Cd- bound, closed state | Descriptor: | CADMIUM ION, MANGANESE ABC TRANSPORTER SUBSTRATE-BINDING LIPOPROTEIN | Authors: | Luo, Z, Counago, R.M, Maher, M, Kobe, B. | Deposit date: | 2014-07-22 | Release date: | 2014-08-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae. Nat Commun, 6, 2015
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7SHJ
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8STB
| The structure of abxF, an enzyme catalyzing the formation of the chiral spiroketal of an anthrabenzoxocinone antibiotic, (-)-ABX | Descriptor: | CHLORIDE ION, GLYCEROL, Glyoxalase, ... | Authors: | Luo, Z, Jia, X, Yan, X, Qu, X, Kobe, B. | Deposit date: | 2023-05-09 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | The crystal structure of abxF, an enzyme catalyzing the formation of the chiral spiroketal of an anthrabenzoxocinone antibiotic, (-)-ABX. To Be Published
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4UTO
| Crystal structure of pneumococcal surface antigen PsaA D280N in the Cd-bound, open state | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CADMIUM ION, MANGANESE ABC TRANSPORTER SUBSTRATE-BINDING LIPOPROTEIN | Authors: | Luo, Z, Counago, R.M, Maher, M, Kobe, B. | Deposit date: | 2014-07-22 | Release date: | 2015-03-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae. Nat Commun, 6, 2015
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7RX1
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7S2Z
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8JZM
| The inhibitor of Toll-like receptor signaling o-vanillin binds covalently to MAL/TIRAP Lys-210 | Descriptor: | Toll/interleukin-1 receptor domain-containing adapter protein | Authors: | Rahaman, M.H, Jia, X, Maxwell, M.J, Mobli, M, Kobe, B. | Deposit date: | 2023-07-05 | Release date: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2. J Enzyme Inhib Med Chem, 39, 2024
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5WEG
| Crystal Structure of UDP-glucose pyrophosphorylase from Sugarcane | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, UTP--glucose-1-phosphate uridylyltransferase | Authors: | Cotrim, C.A, Soares, J.S.M, Kobe, B, Menossi, M. | Deposit date: | 2017-07-10 | Release date: | 2018-03-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure and insights into the oligomeric state of UDP-glucose pyrophosphorylase from sugarcane. PLoS ONE, 13, 2018
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2V1O
| Crystal structure of N-terminal domain of acyl-CoA thioesterase 7 | Descriptor: | COENZYME A, CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE | Authors: | Forwood, J.K, Thakur, A.S, Guncar, G, Marfori, M, Mouradov, D, Meng, W.N, Robinson, J, Huber, T, Kellie, S, Martin, J.L, Hume, D.A, Kobe, B. | Deposit date: | 2007-05-28 | Release date: | 2007-06-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structural Basis for Recruitment of Tandem Hotdog Domains in Acyl-Coa Thioesterase 7 and its Role in Inflammation. Proc.Natl.Acad.Sci.USA, 104, 2007
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3EA5
| Kap95p Binding Induces the Switch Loops of RanGDP to adopt the GTP-bound Conformation: Implications for Nuclear Import Complex Assembly Dynamics | Descriptor: | GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, Importin subunit beta-1, ... | Authors: | Forwood, J.K, Lonhienne, J.K, Guncar, G, Stewart, M, Marfori, M, Kobe, B. | Deposit date: | 2008-08-24 | Release date: | 2008-10-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Kap95p binding induces the switch loops of RanGDP to adopt the GTP-bound conformation: implications for nuclear import complex assembly dynamics. J.Mol.Biol., 383, 2008
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4ZM5
| Shigella flexneri lipopolysaccharide O-antigen chain-length regulator WzzBSF - A107P mutant | Descriptor: | CHLORIDE ION, Chain length determinant protein, MAGNESIUM ION | Authors: | Ericsson, D.J, Chang, C.-W, Lonhienne, T, Casey, L, Benning, F, Kobe, B, Tran, E.N.H, Morona, R. | Deposit date: | 2015-05-02 | Release date: | 2016-03-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | Structural and Biochemical Analysis of a Single Amino-Acid Mutant of WzzBSF That Alters Lipopolysaccharide O-Antigen Chain Length in Shigella flexneri. Plos One, 10, 2015
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7BER
| SFX structure of the MyD88 TIR domain higher-order assembly (solved, rebuilt and refined using an identical protocol to the MicroED structure of the MyD88 TIR domain higher-order assembly) | Descriptor: | Myeloid differentiation primary response protein MyD88 | Authors: | Clabbers, M.T.B, Holmes, S, Muusse, T.W, Vajjhala, P, Thygesen, S.J, Malde, A.K, Hunter, D.J.B, Croll, T.I, Nanson, J.D, Rahaman, M.H, Aquila, A, Hunter, M.S, Liang, M, Yoon, C.H, Zhao, J, Zatsepin, N.A, Abbey, B, Sierecki, E, Gambin, Y, Darmanin, C, Kobe, B, Xu, H, Ve, T. | Deposit date: | 2020-12-24 | Release date: | 2021-03-10 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography. Nat Commun, 12, 2021
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7BEQ
| MicroED structure of the MyD88 TIR domain higher-order assembly | Descriptor: | Myeloid differentiation primary response protein MyD88 | Authors: | Clabbers, M.T.B, Holmes, S, Muusse, T.W, Vajjhala, P, Thygesen, S.J, Malde, A.K, Hunter, D.J.B, Croll, T.I, Nanson, J.D, Rahaman, M.H, Aquila, A, Hunter, M.S, Liang, M, Yoon, C.H, Zhao, J, Zatsepin, N.A, Abbey, B, Sierecki, E, Gambin, Y, Darmanin, C, Kobe, B, Xu, H, Ve, T. | Deposit date: | 2020-12-24 | Release date: | 2021-03-10 | Last modified: | 2024-01-31 | Method: | ELECTRON CRYSTALLOGRAPHY (3 Å) | Cite: | MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography. Nat Commun, 12, 2021
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7RTC
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6C80
| Crystal structure of a flax cytokinin oxidase | Descriptor: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, AMMONIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Wan, L, Williams, S, Kobe, B. | Deposit date: | 2018-01-23 | Release date: | 2018-06-20 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structural and functional insights into the modulation of the activity of a flax cytokinin oxidase by flax rust effector AvrL567-A. Mol. Plant Pathol., 20, 2019
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