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PDB: 1641 results

4LAP
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BU of 4lap by Molmil
Endothiapepsin in complex with thiophen-based inhibitor SAP114
Descriptor: DIMETHYL SULFOXIDE, Endothiapepsin, GLYCEROL, ...
Authors:Park, A, Heine, A, Klebe, G.
Deposit date:2013-06-20
Release date:2014-12-24
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Endothiapepsin in Complex with Thiophen based Inhibitors
To be Published
3EOU
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BU of 3eou by Molmil
tRNA-guanine transglycosylase in complex with 6-amino-4-(2-hydroxyethyl)-2-(methylamino)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
Descriptor: 6-amino-4-(2-hydroxyethyl)-2-(methylamino)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ...
Authors:Ritschel, T, Heine, A, Klebe, G.
Deposit date:2008-09-29
Release date:2009-09-15
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:How to Replace the Residual Solvation Shell of Polar Active Site Residues to Achieve Nanomolar Inhibition of tRNA-Guanine Transglycosylase
Chemmedchem, 4, 2009
3C2Y
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BU of 3c2y by Molmil
tRNA-Guanine Transglycosylase (TGT) in complex with 6-Amino-2-methyl-1,7-dihydro-imidazo[4,5-g]quinazolin-8-one
Descriptor: 6-amino-2-methyl-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ...
Authors:Ritschel, T, Heine, A, Klebe, G.
Deposit date:2008-01-26
Release date:2009-02-03
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Crystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGT
Chembiochem, 10, 2009
1Y5A
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BU of 1y5a by Molmil
Dianhydrosugar-based benzamidine, factor Xa specific inhibitor in complex with bovine trypsin mutant
Descriptor: 2-O-{4-[AMINO(IMINO)METHYL]PHENYL}-5-O-{3-[AMINO(IMINO)METHYL]PHENYL}-1,4:3,6-DIANHYDRO-D-GLUCITOL, CALCIUM ION, GLYCEROL, ...
Authors:Di Fenza, A, Heine, A, Klebe, G.
Deposit date:2004-12-02
Release date:2005-12-13
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Understanding binding selectivity toward trypsin and factor Xa: the role of aromatic interactions
Chemmedchem, 2, 2007
1Y5B
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BU of 1y5b by Molmil
Dianhydrosugar-based benzamidine, factor Xa specific inhibitor in complex with bovine trypsin mutant
Descriptor: 2,5-BIS-O-{4-[AMINO(IMINO)METHYL]PHENYL}-1,4:3,6-DIANHYDRO-D-GLUCITOL, CALCIUM ION, IMIDAZOLE, ...
Authors:Di Fenza, A, Heine, A, Klebe, G.
Deposit date:2004-12-02
Release date:2005-12-13
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Understanding binding selectivity toward trypsin and factor Xa: the role of aromatic interactions
Chemmedchem, 2, 2007
3EOS
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BU of 3eos by Molmil
tRNA-guanine transglycosylase in complex with 6-amino-4-{2-[(cyclohexylmethyl)amino]ethyl}-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
Descriptor: 6-amino-4-{2-[(cyclohexylmethyl)amino]ethyl}-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ...
Authors:Ritschel, T, Heine, A, Klebe, G.
Deposit date:2008-09-29
Release date:2009-09-15
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:How to Replace the Residual Solvation Shell of Polar Active Site Residues to Achieve Nanomolar Inhibition of tRNA-Guanine Transglycosylase
Chemmedchem, 4, 2009
1YPE
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BU of 1ype by Molmil
Thrombin Inhibitor Complex
Descriptor: (1R,3AS,4R,8AS,8BR)-4-(2-BENZO[1,3]DIOXOL-5-YLMETHYL-1-ETHYL-3-OXO-DECAHYDRO-PYRROLO[3,4-A]PYRROLIZIN-4-YL)-BENZAMIDINE, GLYCEROL, Hirudin, ...
Authors:Fokkens, J, Obst-Sander, U, Heine, A, Diederich, F, Klebe, G.
Deposit date:2005-01-31
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:A simple protocol to estimate differences in protein binding affinity for enantiomers without prior resolution of racemates
Angew.Chem.Int.Ed.Engl., 45, 2006
1YPK
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BU of 1ypk by Molmil
Thrombin Inhibitor Complex
Descriptor: 10-mer peptide from Acety-Hirudin(54-65) sulfated, Prothrombin heavy chain, Prothrombin light chain, ...
Authors:Czodrowski, P, Sotriffer, C, Fokkens, J, Heine, A, Klebe, G.
Deposit date:2005-01-31
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:A Simple Protocol To Estimate Differences in Protein Binding Affinity for Enantiomers without Prior Resolution of Racemates
Angew.Chem.Int.Ed.Engl., 45, 2006
1YPG
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BU of 1ypg by Molmil
Thrombin Inhibitor Complex
Descriptor: (1R,3AS,4R,8AS,8BR)-4-(2-BENZO[1,3]DIOXOL-5-YL-1-CYCLOPROPYL-3-OXO-DECAHYDRO-PYRROLO[3,4-A]PYRROLIZIN-4-YL)-BENZAMIDINE, Hirudin, Thrombin heavy chain, ...
Authors:Fokkens, J, Obst-Sander, U, Heine, A, Diederich, F, Klebe, G.
Deposit date:2005-01-31
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A simple protocol to estimate differences in protein binding affinity for enantiomers without prior resolution of racemates
Angew.Chem.Int.Ed.Engl., 45, 2006
4E7R
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BU of 4e7r by Molmil
Thrombin in complex with 3-amidinophenylalanine inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(2S)-3-[4-(2-aminoethyl)piperidin-1-yl]-2-{[(2',4'-dichlorobiphenyl-3-yl)sulfonyl]amino}-3-oxopropyl]benzenecarboximidamide, GLYCEROL, ...
Authors:Ruehmann, E, Heine, A, Klebe, G.
Deposit date:2012-03-19
Release date:2012-06-20
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:New 3-amidinophenylalanine-derived inhibitors of matriptase
MEDCHEMCOMM, 3, 2012
6G4L
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BU of 6g4l by Molmil
17beta-hydroxysteroid Dehydrogenase Type 14 Mutant Y253A in Complex With a Non-steroidal Inhibitor
Descriptor: 17-beta-hydroxysteroid dehydrogenase 14, DIMETHYL SULFOXIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Badran, M, Klebe, G, Heine, A, Marchais-Oberwinkler, S.
Deposit date:2018-03-27
Release date:2019-04-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.444 Å)
Cite:Mutational and structural studies uncover crucial amino acids determining activity and stability of 17beta-HSD14
J.Steroid Biochem.Mol.Biol., 2019
6GDC
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BU of 6gdc by Molmil
Human Carbonic Anhydrase II in complex with Benzenesulfonamide
Descriptor: Carbonic anhydrase 2, MERCURIBENZOIC ACID, MERCURY (II) ION, ...
Authors:Gloeckner, S, Heine, A, Klebe, G.
Deposit date:2018-04-23
Release date:2019-05-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.079 Å)
Cite:Conformational Changes in Alkyl Chains Determine the Thermodynamic and Kinetic Binding Profiles of Carbonic Anhydrase Inhibitors.
Acs Chem.Biol., 15, 2020
1YVM
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BU of 1yvm by Molmil
E. coli Methionine Aminopeptidase in complex with thiabendazole
Descriptor: 2-(1,3-THIAZOL-4-YL)-1H-BENZIMIDAZOLE, COBALT (II) ION, Methionine aminopeptidase, ...
Authors:Schiffmann, R, Heine, A, Klebe, G, Klein, C.D.
Deposit date:2005-02-16
Release date:2005-06-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Metal Ions as Cofactors for the Binding of Inhibitors to Methionine Aminopeptidase: A Critical View of the Relevance of In Vitro Metalloenzyme Assays.
Angew.Chem.Int.Ed.Engl., 44, 2005
6GM9
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BU of 6gm9 by Molmil
Human Carbonic Anhydrase II in complex with 4-Methylbenzenesulfonamide
Descriptor: 4-methylbenzenesulfonamide, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ...
Authors:Gloeckner, S, Heine, A, Klebe, G.
Deposit date:2018-05-24
Release date:2019-06-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.089 Å)
Cite:Conformational Changes in Alkyl Chains Determine the Thermodynamic and Kinetic Binding Profiles of Carbonic Anhydrase Inhibitors.
Acs Chem.Biol., 15, 2020
6H7C
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BU of 6h7c by Molmil
tRNA guanine transglycosylase H333A mutant apo structure
Descriptor: GLYCEROL, Queuine tRNA-ribosyltransferase, ZINC ION
Authors:Nguyen, T.X.P, Heine, A, Klebe, G.
Deposit date:2018-07-31
Release date:2019-08-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.681 Å)
Cite:tRNA guanine transglycosylase H333A mutant apo structure
To Be Published
6GTB
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BU of 6gtb by Molmil
17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with FB211
Descriptor: 1,2-ETHANEDIOL, 17-beta-hydroxysteroid dehydrogenase 14, 3-[6-(3-hydroxyphenyl)pyridin-2-yl]benzoic acid, ...
Authors:Bertoletti, N, Marchais-Oberwinkler, S, Heine, A, Klebe, G.
Deposit date:2018-06-18
Release date:2019-09-11
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.619 Å)
Cite:X-ray Crystallographic Fragment screening and Hit Optimization
To Be Published
6EMM
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BU of 6emm by Molmil
17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with Salicylic acid
Descriptor: 17-beta-hydroxysteroid dehydrogenase 14, 2-HYDROXYBENZOIC ACID, DI(HYDROXYETHYL)ETHER, ...
Authors:Bertoletti, N, Marchais-Oberwinkler, S, Heine, A, Klebe, G.
Deposit date:2017-10-02
Release date:2018-10-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:X-ray Crystallographic Fragment screening and Hit Optimization
To Be Published
1YPJ
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BU of 1ypj by Molmil
Thrombin Inhibitor Complex
Descriptor: (1R,3AS,4R,8AS,8BR)-4-{5-(PHENYL[1,3]DIOXOL-5-YLMETHYL)-4-ETHYL-2,3,3-TRIMETHYL-6-OXO-OCTAHYDRO-PYRROLO[3,4-C]PYRROL-1-YL}-BENZAMIDINE, Hirudin, Thrombin heavy chain, ...
Authors:Fokkens, J, Obst-Sander, U, Heine, A, Diederich, F, Klebe, G.
Deposit date:2005-01-31
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:A simple protocol to estimate differences in protein binding affinity for enantiomers without prior resolution of racemates
Angew.Chem.Int.Ed.Engl., 45, 2006
6HXD
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BU of 6hxd by Molmil
Human Carbonic Anhydrase II in complex with 4-Butylbenzenesulfonamide
Descriptor: 4-butylbenzenesulfonamide, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ...
Authors:Gloeckner, S, Heine, A, Klebe, G.
Deposit date:2018-10-17
Release date:2019-10-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.119 Å)
Cite:Conformational Changes in Alkyl Chains Determine the Thermodynamic and Kinetic Binding Profiles of Carbonic Anhydrase Inhibitors.
Acs Chem.Biol., 15, 2020
6HQX
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BU of 6hqx by Molmil
Human Carbonic Anhydrase II in complex with 4-Ethylbenzenesulfonamide
Descriptor: (4-CARBOXYPHENYL)(CHLORO)MERCURY, 4-ethylbenzenesulfonamide, Carbonic anhydrase 2, ...
Authors:Gloeckner, S, Heine, A, Klebe, G.
Deposit date:2018-09-25
Release date:2019-10-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.097 Å)
Cite:Conformational Changes in Alkyl Chains Determine the Thermodynamic and Kinetic Binding Profiles of Carbonic Anhydrase Inhibitors.
Acs Chem.Biol., 15, 2020
6I2F
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BU of 6i2f by Molmil
Human Carbonic Anhydrase II in complex with 4-Propoxybenzenesulfonamide
Descriptor: 4-propoxybenzenesulfonamide, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ...
Authors:Gloeckner, S, Heine, A, Klebe, G.
Deposit date:2018-11-01
Release date:2019-11-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.198 Å)
Cite:Conformational Changes in Alkyl Chains Determine the Thermodynamic and Kinetic Binding Profiles of Carbonic Anhydrase Inhibitors.
Acs Chem.Biol., 15, 2020
6HR3
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BU of 6hr3 by Molmil
Human Carbonic Anhydrase II in complex with 4-Propylbenzenesulfonamide
Descriptor: 4-propylbenzenesulfonamide, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ...
Authors:Gloeckner, S, Heine, A, Klebe, G.
Deposit date:2018-09-26
Release date:2019-10-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:Conformational Changes in Alkyl Chains Determine the Thermodynamic and Kinetic Binding Profiles of Carbonic Anhydrase Inhibitors.
Acs Chem.Biol., 15, 2020
4YX4
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BU of 4yx4 by Molmil
Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (1).
Descriptor: Carbonic anhydrase 2, GLYCEROL, MERCURIBENZOIC ACID, ...
Authors:Rechlin, C, Heine, A, Klebe, G.
Deposit date:2015-03-22
Release date:2016-02-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.01 Å)
Cite:Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies.
J.Med.Chem., 59, 2016
6Z44
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BU of 6z44 by Molmil
Crystal structure of the cAMP-dependent protein kinase A in complex with phenol
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, DIMETHYL SULFOXIDE, PHENOL, ...
Authors:Oebbeke, M, Heine, A, Klebe, G.
Deposit date:2020-05-22
Release date:2020-12-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts.
Angew.Chem.Int.Ed.Engl., 60, 2021
6ZN0
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BU of 6zn0 by Molmil
Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with isonicotinamidine
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, DIMETHYL SULFOXIDE, ISONICOTINAMIDINE, ...
Authors:Oebbeke, M, Heine, A, Klebe, G.
Deposit date:2020-07-06
Release date:2020-12-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts.
Angew.Chem.Int.Ed.Engl., 60, 2021

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數據於2024-06-26公開中

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