8B3N

Human Aldose Reductase Mutant A299G/L300G in Complex with a Ligand with an IDD Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid)

Summary for 8B3N

• Entry DOI: 10.2210/pdb8b3n/pdb
• Descriptor: Aldo-keto reductase family 1 member B1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid, ... (5 entities in total)
• Functional Keywords: human aldose reductase, har, aldo-keto-reductase, mutant a299g/l300g, sar_061 ligand, nadp+, diabetes, ligand in transient pocket, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 37111.03

Authors

Hubert, L.-S.,Heine, A.,Klebe, G. (deposition date: 2022-09-16, release date: 2023-09-27)

• Primary citation: Hubert, L.-S.,Heine, A.,Klebe, G.; Human Aldose Reductase Mutant A299G/L300G in Complex with a Ligand with an IDD Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid); To Be Published,

Experimental method

X-RAY DIFFRACTION (1.03 Å)