8SRL
 
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6XB9
 | | Crystal structure of Azotobacter vinelandii 3-mercaptopropionic acid dioxygenase in complex with 3-hydroxypropionic acid | | 分子名称: | 3-HYDROXY-PROPANOIC ACID, CHLORIDE ION, Cysteine dioxygenase type I protein, ... | | 著者 | Kiser, P.D, Khadka, N, Shi, W, Pierce, B.S. | | 登録日 | 2020-06-05 | | 公開日 | 2021-03-03 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structure of 3-mercaptopropionic acid dioxygenase with a substrate analog reveals bidentate substrate binding at the iron center.
J.Biol.Chem., 296, 2021
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4ZHK
 | | Crystal structure of RPE65 in complex with MB-002 | | 分子名称: | (1R)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, (1S)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, FE (II) ION, ... | | 著者 | Kiser, P.D, Palczewski, K. | | 登録日 | 2015-04-25 | | 公開日 | 2015-05-27 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Molecular pharmacodynamics of emixustat in protection against retinal degeneration.
J.Clin.Invest., 125, 2015
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3KVC
 | | Crystal structure of bovine RPE65 at 1.9 angstrom resolution | | 分子名称: | FE (II) ION, Retinoid isomerohydrolase | | 著者 | Kiser, P.D, Lodowski, D.T, Golczak, M, Palczewski, K. | | 登録日 | 2009-11-29 | | 公開日 | 2010-02-02 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Importance of membrane structural integrity for RPE65 retinoid isomerization activity.
J.Biol.Chem., 285, 2010
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2NWC
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3E76
 | | Crystal structure of Wild-type GroEL with bound Thallium ions | | 分子名称: | 60 kDa chaperonin, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | 著者 | Kiser, P.D, Lorimer, G.H, Palczewski, K. | | 登録日 | 2008-08-17 | | 公開日 | 2009-08-25 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3.94 Å) | | 主引用文献 | Use of thallium to identify monovalent cation binding sites in GroEL.
Acta Crystallogr.,Sect.F, 65, 2009
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3FSN
 | | Crystal structure of RPE65 at 2.14 angstrom resolution | | 分子名称: | FE (II) ION, Retinal pigment epithelium-specific 65 kDa protein, TETRAETHYLENE GLYCOL | | 著者 | Kiser, P.D, Lodowski, D.T, Palczewski, K. | | 登録日 | 2009-01-11 | | 公開日 | 2009-09-29 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Crystal structure of native RPE65, the retinoid isomerase of the visual cycle.
Proc.Natl.Acad.Sci.USA, 106, 2009
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3VAT
 | | Crystal structure of DNPEP, ZnMg form | | 分子名称: | Aspartyl aminopeptidase, MAGNESIUM ION, ZINC ION | | 著者 | Kiser, P.D, Chen, Y, Palczewski, K. | | 登録日 | 2011-12-29 | | 公開日 | 2012-02-29 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Insights into substrate specificity and metal activation of Mammalian tetrahedral aspartyl aminopeptidase.
J.Biol.Chem., 287, 2012
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3VAR
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4RYX
 | | Crystal structure of RPE65 in complex with emixustat and palmitate, P6522 crystal form | | 分子名称: | (1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol, (4S)-2-METHYL-2,4-PENTANEDIOL, FE (II) ION, ... | | 著者 | Kiser, P.D, Palczewski, K. | | 登録日 | 2014-12-17 | | 公開日 | 2015-05-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Molecular pharmacodynamics of emixustat in protection against retinal degeneration.
J.Clin.Invest., 125, 2015
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4RSE
 | | Crystal structure of RPE65 in complex with MB-001 and palmitate | | 分子名称: | (1R)-3-amino-1-{3-[(2,6,6-trimethylcyclohex-1-en-1-yl)methoxy]phenyl}propan-1-ol, FE (II) ION, PALMITIC ACID, ... | | 著者 | Kiser, P.D, Shi, W, Palczewski, K. | | 登録日 | 2014-11-07 | | 公開日 | 2015-04-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Catalytic mechanism of a retinoid isomerase essential for vertebrate vision.
Nat.Chem.Biol., 11, 2015
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4RYY
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4RYZ
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4RSC
 | | Crystal structure of RPE65 in complex with emixustat and palmitate | | 分子名称: | (1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol, FE (II) ION, PALMITIC ACID, ... | | 著者 | Kiser, P.D, Shi, W, Palczewski, K. | | 登録日 | 2014-11-07 | | 公開日 | 2015-04-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Catalytic mechanism of a retinoid isomerase essential for vertebrate vision.
Nat.Chem.Biol., 11, 2015
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8FTY
 | | Crystal structure of the carotenoid isomerooxygenase, NinaB | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, CHLORIDE ION, ... | | 著者 | Kiser, P.D, Solano, Y.J. | | 登録日 | 2023-01-14 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-06-12 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore.
Nat.Chem.Biol., 20, 2024
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8FU2
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8FU5
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6C7O
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6C7P
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6C7K
 | | Crystal structure of an ACO/RPE65 chimera | | 分子名称: | Apocarotenoid-15,15'-oxygenase, CHLORIDE ION, FE (II) ION | | 著者 | Kiser, P.D, Shi, W. | | 登録日 | 2018-01-22 | | 公開日 | 2018-04-25 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65.
Hum.Mol.Genet., 27, 2018
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4F3A
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4DPZ
 | | Crystal structure of human HRASLS2 | | 分子名称: | HRAS-like suppressor 2 | | 著者 | Kiser, P.D, Golczak, M, Sears, A.E, Lodowski, D.T, Palczewski, K. | | 登録日 | 2012-02-14 | | 公開日 | 2012-05-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Structural Basis for the Acyltransferase Activity of Lecithin:Retinol Acyltransferase-like Proteins.
J.Biol.Chem., 287, 2012
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4F3D
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4DOT
 | | Crystal structure of human HRASLS3. | | 分子名称: | Group XVI phospholipase A2 | | 著者 | Kiser, P.D, Golczak, M, Sears, A.E, Lodowski, D.T, Palczewski, K. | | 登録日 | 2012-02-10 | | 公開日 | 2012-05-30 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Structural Basis for the Acyltransferase Activity of Lecithin:Retinol Acyltransferase-like Proteins.
J.Biol.Chem., 287, 2012
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4F2Z
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