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PDB: 91 件
1FBD
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CRYSTALLOGRAPHIC STUDIES OF THE CATALYTIC MECHANISM OF THE NEUTRAL FORM OF FRUCTOSE-1,6-BISPHOSPHATASE
分子名称: 2,5-anhydro-1,6-di-O-phosphono-D-glucitol, FRUCTOSE 1,6-BISPHOSPHATASE, MANGANESE (II) ION
著者Zhang, Y, Liang, J.-Y, Huang, S, Ke, H, Lipscomb, W.N.
登録日1992-10-16
公開日1993-10-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase.
Biochemistry, 32, 1993
2FM0
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Crystal structure of PDE4D in complex with L-869298
分子名称: (S)-3-(2-(3-CYCLOPROPOXY-4-(DIFLUOROMETHOXY)PHENYL)-2-(5-(1,1,1,3,3,3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL)THIAZOL-2-YL)ETHY L)PYRIDINE 1-OXIDE, MAGNESIUM ION, ZINC ION, ...
著者Huai, Q, Sun, Y, Wang, H, Macdonald, D, Aspiotis, R, Robinson, H, Huang, Z, Ke, H.
登録日2006-01-06
公開日2006-03-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Enantiomer Discrimination Illustrated by the High Resolution Crystal Structures of Type 4 Phosphodiesterase
J.Med.Chem., 49, 2006
2FM5
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Crystal structure of PDE4D2 in complex with inhibitor L-869299
分子名称: (R)-3-(2-(3-CYCLOPROPOXY-4-(DIFLUOROMETHOXY)PHENYL)-2-(5-(1,1,1,3,3,3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL)THIAZOL-2-YL)ETHYL)PYRIDINE 1-OXIDE, MAGNESIUM ION, ZINC ION, ...
著者Huai, Q, Sun, Y, Wang, H, Macdonald, D, Aspiotis, R, Robinson, H, Huang, Z, Ke, H.
登録日2006-01-07
公開日2006-03-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Enantiomer Discrimination Illustrated by the High Resolution Crystal Structures of Type 4 Phosphodiesterase
J.Med.Chem., 49, 2006
1FBF
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CRYSTALLOGRAPHIC STUDIES OF THE CATALYTIC MECHANISM OF THE NEUTRAL FORM OF FRUCTOSE-1,6-BISPHOSPHATASE
分子名称: 2,5-anhydro-1,6-di-O-phosphono-D-mannitol, FRUCTOSE 1,6-BISPHOSPHATASE, MAGNESIUM ION
著者Zhang, Y, Liang, J.-Y, Huang, S, Ke, H, Lipscomb, W.N.
登録日1992-10-16
公開日1993-10-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase.
Biochemistry, 32, 1993
2H44
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Crystal structure of PDE5A1 in complex with icarisid II
分子名称: 5,7-DIHYDROXY-2-(4-METHOXYPHENYL)-8-(3-METHYLBUTYL)-4-OXO-4H-CHROMEN-3-YL 6-DEOXY-ALPHA-L-MANNOPYRANOSIDE, MAGNESIUM ION, ZINC ION, ...
著者Wang, H, Ke, H.
登録日2006-05-23
公開日2006-06-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development
J.Biol.Chem., 281, 2006
1FBG
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CRYSTALLOGRAPHIC STUDIES OF THE CATALYTIC MECHANISM OF THE NEUTRAL FORM OF FRUCTOSE-1,6-BISPHOSPHATASE
分子名称: 2,5-anhydro-1,6-di-O-phosphono-D-mannitol, FRUCTOSE 1,6-BISPHOSPHATASE, MANGANESE (II) ION
著者Zhang, Y, Liang, J.-Y, Huang, S, Ke, H, Lipscomb, W.N.
登録日1992-10-16
公開日1993-10-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase.
Biochemistry, 32, 1993
2CHS
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CRYSTAL STRUCTURES OF THE MONOFUNCTIONAL CHORISMATE MUTASE FROM BACILLUS SUBTILIS AND ITS COMPLEX WITH A TRANSITION STATE ANALOG
分子名称: CHORISMATE MUTASE
著者Chook, Y.M, Ke, H, Lipscomb, W.N.
登録日1994-04-08
公開日1994-07-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog.
Proc.Natl.Acad.Sci.USA, 90, 1993
1KKG
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NMR Structure of Ribosome-Binding Factor A (RbfA)
分子名称: ribosome-binding factor A
著者Huang, Y.J, Swapna, G.V.T, Rajan, P.K, Ke, H, Xia, B, Shukla, K, Inouye, M, Montelione, G.T, Northeast Structural Genomics Consortium (NESG)
登録日2001-12-07
公開日2003-03-18
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution NMR Structure of Ribosome-binding Factor A (RbfA), A Cold-shock Adaptation Protein from Escherichia coli
J.Mol.Biol., 327, 2003
3ECN
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Crystal structure of PDE8A catalytic domain in complex with IBMX
分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ...
著者Wang, H, Yan, Z, Yang, S, Cai, J, Robinson, H, Ke, H.
登録日2008-09-01
公開日2008-11-25
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity
Biochemistry, 47, 2008
2CYH
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CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE ALA-PRO
分子名称: ALANINE, CYCLOPHILIN A, PROLINE
著者Zhao, Y, Ke, H.
登録日1996-02-27
公開日1996-07-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Mechanistic implication of crystal structures of the cyclophilin-dipeptide complexes.
Biochemistry, 35, 1996
3V93
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unliganded structure of TcrPDEC1 catalytic domain
分子名称: Cyclic nucleotide specific phosphodiesterase, MAGNESIUM ION, ZINC ION
著者Wang, H, Kunz, S, Chen, G, Seebeck, T, Wan, Y, Robinson, H, Martinelli, S, Ke, H.
登録日2011-12-23
公開日2012-02-22
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors.
J.Biol.Chem., 287, 2012
3V94
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TcrPDEC1 catalytic domain in complex with inhibitor wyq16
分子名称: Cyclic nucleotide specific phosphodiesterase, MAGNESIUM ION, ZINC ION, ...
著者Wang, H, Kunz, S, Chen, G, Seebeck, T, Wan, Y, Robinson, H, Martinelli, S, Ke, H.
登録日2011-12-23
公開日2012-02-22
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献TcrPDEC1 catalytic domain in complex with inhibitor wyq16
To be Published
3ECM
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Crystal structure of the unliganded PDE8A catalytic domain
分子名称: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ZINC ION
著者Wang, H, Yan, Z, Yang, S, Cai, J, Robinson, H, Ke, H.
登録日2008-09-01
公開日2008-11-25
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity
Biochemistry, 47, 2008
1ZKN
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Structure of PDE4D2-IBMX
分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, MAGNESIUM ION, ZINC ION, ...
著者Huai, Q, Liu, Y, Francis, S.H, Corbin, J.D, Ke, H.
登録日2005-05-03
公開日2005-05-17
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structures of Phosphodiesterases 4 and 5 in Complex with Inhibitor 3-Isobutyl-1-Methylxanthine Suggest a Conformation Determinant of Inhibitor Selectivity
J.Biol.Chem., 279, 2004
1ZKL
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Multiple Determinants for Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases
分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, MAGNESIUM ION, ...
著者Wang, H, Liu, Y, Chen, Y, Robinson, H, Ke, H.
登録日2005-05-03
公開日2005-07-05
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7
J.Biol.Chem., 280, 2005
3MF0
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Crystal structure of PDE5A GAF domain (89-518)
分子名称: cGMP-specific 3',5'-cyclic phosphodiesterase
著者Wang, H, Robinson, H, Ke, H.
登録日2010-04-01
公開日2010-09-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Conformation changes, N-terminal involvement, and cGMP signal relay in the phosphodiesterase-5 GAF domain.
J.Biol.Chem., 285, 2010
2OUN
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crystal structure of PDE10A2 in complex with AMP
分子名称: ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ZINC ION, ...
著者Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H, Ke, H.M.
登録日2007-02-12
公開日2007-03-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献From the Cover: Structural insight into substrate specificity of phosphodiesterase 10.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2HD1
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Crystal structure of PDE9 in complex with IBMX
分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, MAGNESIUM ION, Phosphodiesterase 9A, ...
著者Huai, Q, Wang, H, Zhang, W, Colman, R.W, Robinson, H, Ke, H.
登録日2006-06-19
公開日2006-06-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor IBMX binding
Proc.Natl.Acad.Sci.USA, 101, 2004
1Y4U
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Conformation rearrangement of heat shock protein 90 upon ADP binding
分子名称: Chaperone protein htpG
著者Huai, Q, Wang, H, Liu, Y, Kim, H, Toft, D, Ke, H.
登録日2004-12-01
公開日2005-04-19
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding.
Structure, 13, 2005
1Y4S
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Conformation rearrangement of heat shock protein 90 upon ADP binding
分子名称: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein htpG, MAGNESIUM ION
著者Huai, Q, Wang, H, Liu, Y, Kim, H, Toft, D, Ke, H.
登録日2004-12-01
公開日2005-04-19
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding.
Structure, 13, 2005
1M63
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Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
分子名称: CALCINEURIN B SUBUNIT ISOFORM 1, CALCIUM ION, CYCLOSPORIN A, ...
著者Huai, Q, Kim, H.-Y, Liu, Y, Zhao, Y, Mondragon, A, Liu, J.O, Ke, H.
登録日2002-07-12
公開日2002-09-25
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of Calcineurin-Cyclophilin-Cyclosporin Shows Common But Distinct Recognition of Immunophilin-Drug Complexes
Proc.Natl.Acad.Sci.USA, 99, 2002
1FPB
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CRYSTAL STRUCTURE OF THE NEUTRAL FORM OF FRUCTOSE 1,6-BISPHOSPHATASE COMPLEXED WITH REGULATORY INHIBITOR FRUCTOSE 2,6-BISPHOSPHATE AT 2.6-ANGSTROMS RESOLUTION
分子名称: 2,6-di-O-phosphono-beta-D-fructofuranose, FRUCTOSE 1,6-BISPHOSPHATASE
著者Liang, J.Y, Huang, S, Zhang, Y, Ke, H, Lipscomb, W.N.
登録日1992-02-03
公開日1993-10-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of the neutral form of fructose 1,6-bisphosphatase complexed with regulatory inhibitor fructose 2,6-bisphosphate at 2.6-A resolution.
Proc.Natl.Acad.Sci.USA, 89, 1992
6CFE
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Crystal structure of C2S5: A computationally designed immunogen to target Carbohydrate-Occluded Epitopes on the HIV envelope
分子名称: Mutant of Apolipoprotein E3 (APO-E3)
著者Zhu, C, Ke, H.M, Swanstrom, R, Dokholyan, N.V.
登録日2018-02-14
公開日2019-02-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.994 Å)
主引用文献Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies.
Nat Commun, 10, 2019
6CBU
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Crystal structure of C4S3: A computationally designed immunogen to target Carbohydrate-Occluded Epitopes on the HIV envelope
分子名称: Acylphosphatase-1, SULFATE ION
著者Zhu, C, Ke, H.M, Swanstrom, R, Dokholyan, N.V.
登録日2018-02-05
公開日2019-02-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies.
Nat Commun, 10, 2019
5ED8
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Crystal structure of CC2-SUN of mouse SUN2
分子名称: MAGNESIUM ION, MKIAA0668 protein
著者Nie, S, Ke, H.M, Gao, F, Ren, J.Q, Wang, M.Z, Huo, L, Gong, W.M, Feng, W.
登録日2015-10-21
公開日2016-01-13
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic Regulators
Structure, 24, 2016

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