1ZKL
Multiple Determinants for Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases
Summary for 1ZKL
Entry DOI | 10.2210/pdb1zkl/pdb |
Descriptor | High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | pde, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Isoform PDE7A1: Cytoplasm, cytosol. Isoform PDE7A2: Cytoplasm: Q13946 |
Total number of polymer chains | 1 |
Total formula weight | 41075.08 |
Authors | Wang, H.,Liu, Y.,Chen, Y.,Robinson, H.,Ke, H. (deposition date: 2005-05-03, release date: 2005-07-05, Last modification date: 2024-02-14) |
Primary citation | Wang, H.,Liu, Y.,Chen, Y.,Robinson, H.,Ke, H. Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7 J.Biol.Chem., 280:30949-30955, 2005 Cited by PubMed: 15994308DOI: 10.1074/jbc.M504398200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.67 Å) |
Structure validation
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