1ZKL

Multiple Determinants for Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	HIS216
A	HIS252
A	ASP253
A	ASP362
A	HOH504
A	HOH509

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 502

Chain	Residue
A	HOH507
A	HOH508
A	HOH509
A	ASP253
A	HOH505
A	HOH506

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE IBM A 503

Chain	Residue
A	TYR211
A	VAL380
A	PHE384
A	ILE412
A	GLN413
A	PHE416
A	HOH542
A	HOH552
A	HOH573

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHpGvnQpF

Chain	Residue	Details
A	HIS252-PHE263

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15994308","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19350606","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---