1WR6
 
 | | Crystal structure of GGA3 GAT domain in complex with ubiquitin | | 分子名称: | ADP-ribosylation factor binding protein GGA3, ubiquitin | | 著者 | Kawasaki, M, Shiba, T, Shiba, Y, Yamaguchi, Y, Matsugaki, N, Igarashi, N, Suzuki, M, Kato, R, Kato, K, Nakayama, K, Wakatsuki, S. | | 登録日 | 2004-10-12 | | 公開日 | 2005-06-28 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Molecular mechanism of ubiquitin recognition by GGA3 GAT domain.
Genes Cells, 10, 2005
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7WAC
 | | Trichodesmium erythraeum cyanophycin synthetase 1 (TeCphA1) | | 分子名称: | Cyanophycin synthase | | 著者 | Kawasaki, M, Miyakawa, T, Yang, J, Adachi, N, Fujii, A, Miyauchi, Y, Muramatsu, T, Moriya, T, Senda, T, Tanokura, M. | | 登録日 | 2021-12-14 | | 公開日 | 2022-09-07 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | | 主引用文献 | Structural bases for aspartate recognition and polymerization efficiency of cyanobacterial cyanophycin synthetase.
Nat Commun, 13, 2022
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7WAD
 | | Trichodesmium erythraeum cyanophycin synthetase 1 (TeCphA1) with ATPgammaS | | 分子名称: | Cyanophycin synthase, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | 著者 | Kawasaki, M, Miyakawa, T, Yang, J, Adachi, N, Fujii, A, Miyauchi, Y, Muramatsu, T, Moriya, T, Senda, T, Tanokura, M. | | 登録日 | 2021-12-14 | | 公開日 | 2022-09-07 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | | 主引用文献 | Structural bases for aspartate recognition and polymerization efficiency of cyanobacterial cyanophycin synthetase.
Nat Commun, 13, 2022
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1IO6
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6JNO
 | | RXRa structure complexed with CU-6PMN | | 分子名称: | 7-oxidanyl-2-oxidanylidene-6-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)chromene-3-carboxylic acid, Retinoic acid receptor RXR-alpha | | 著者 | Kawasaki, M, Nakano, S, Motoyama, T, Yamada, S, Watanabe, M, Takamura, Y, Fujihara, M, Tokiwa, H, Kakuta, H, Ito, S. | | 登録日 | 2019-03-17 | | 公開日 | 2019-11-20 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening.
J.Med.Chem., 62, 2019
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6JNR
 | | RXRa structure complexed with CU-6PMN and SRC1 peptide. | | 分子名称: | 7-oxidanyl-2-oxidanylidene-6-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)chromene-3-carboxylic acid, HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN, Retinoic acid receptor RXR-alpha | | 著者 | Kawasaki, M, Nakano, S, Motoyama, T, Yamada, S, Watanabe, M, Takamura, Y, Fujihara, M, Tokiwa, H, Kakuta, H, Ito, S. | | 登録日 | 2019-03-18 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | RXRa structure complexed with CU-6PMN and SRC1 peptide.
To Be Published
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6L96
 | | Structure of PPARalpha-LBD/pemafibrate/SRC1 peptide | | 分子名称: | (2~{R})-2-[3-[[1,3-benzoxazol-2-yl-[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]butanoic acid, Peroxisome proliferator-activated receptor alpha, SRC1 coactivator peptide | | 著者 | Kawasaki, M, Kambe, A, Yamamoto, Y, Arulmozhira, S, Ito, S, Nakagawa, Y, Tokiwa, H, Nakano, S, Shimano, H. | | 登録日 | 2019-11-08 | | 公開日 | 2020-01-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Elucidation of Molecular Mechanism of a Selective PPAR alpha Modulator, Pemafibrate, through Combinational Approaches of X-ray Crystallography, Thermodynamic Analysis, and First-Principle Calculations.
Int J Mol Sci, 21, 2020
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1O3Y
 | | Crystal structure of mouse ARF1 (delta17-Q71L), GTP form | | 分子名称: | ADP-ribosylation factor 1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | | 著者 | Shiba, T, Kawasaki, M, Takatsu, H, Nogi, T, Matsugaki, N, Igarashi, N, Suzuki, M, Kato, R, Nakayama, K, Wakatsuki, S. | | 登録日 | 2003-05-08 | | 公開日 | 2003-05-20 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport
Nat.Struct.Biol., 10, 2003
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8Y6H
 | | P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in LMNG detergent | | 分子名称: | ATP-dependent translocase ABCB1,mNeonGreen, UIC2 Fab heavy chain, UIC2 Fab light chain, ... | | 著者 | Hamaguchi-Suzuki, N, Adachi, N, Moriya, T, Kawasaki, M, Suzuki, K, Anzai, N, Senda, T, Murata, T. | | 登録日 | 2024-02-02 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | | 主引用文献 | Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules.
Biochem.Biophys.Res.Commun., 709, 2024
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8Y6I
 | | P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in nanodisc | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, ATP-dependent translocase ABCB1,mNeonGreen, CHOLESTEROL, ... | | 著者 | Hamaguchi-Suzuki, N, Adachi, N, Moriya, T, Kawasaki, M, Suzuki, K, Anzai, N, Senda, T, Murata, T. | | 登録日 | 2024-02-02 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | | 主引用文献 | Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules.
Biochem.Biophys.Res.Commun., 709, 2024
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8ISN
 | | HLA-A24 in complex with modified 9mer WT1 peptide | | 分子名称: | Beta-2-microglobulin, CYS-TYR-THR-TRP-ASN-GLN-MET-ASN-LEU, GLYCEROL, ... | | 著者 | Bekker, G.J, Numoto, N, Kawasaki, M, Hayashi, T, Yabuno, S, Kozono, Y, Shimizu, T, Kozono, H, Ito, N, Oda, M, Kamiya, N. | | 登録日 | 2023-03-21 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Elucidation of binding mechanism, affinity, and complex structure between mWT1 tumor-associated antigen peptide and HLA-A*24:02.
Protein Sci., 32, 2023
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1O3X
 | | Crystal structure of human GGA1 GAT domain | | 分子名称: | ADP-ribosylation factor binding protein GGA1 | | 著者 | Shiba, T, Kawasaki, M, Takatsu, H, Nogi, T, Matsugaki, N, Igarashi, N, Suzuki, M, Kato, R, Nakayama, K, Wakatsuki, S. | | 登録日 | 2003-05-08 | | 公開日 | 2003-05-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Molecular Mechanism of Membrane Recruitment of Gga by Arf in Lysosomal Protein Transport
Nat.Struct.Biol., 10, 2003
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4DCN
 | | Crystal Structure Analysis of the Arfaptin2 BAR domain in Complex with ARL1 | | 分子名称: | ADP-ribosylation factor-like protein 1, Arfaptin-2, MAGNESIUM ION, ... | | 著者 | Nakamura, K, Xie, Y, Kawasaki, M, Kato, R, Wakatsuki, S. | | 登録日 | 2012-01-18 | | 公開日 | 2012-06-13 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | | 主引用文献 | Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase
J.Biol.Chem., 287, 2012
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1WRD
 | | Crystal structure of Tom1 GAT domain in complex with ubiquitin | | 分子名称: | Target of Myb protein 1, Ubiquitin | | 著者 | Akutsu, M, Kawasaki, M, Katoh, Y, Shiba, T, Yamaguchi, Y, Kato, R, Kato, K, Nakayama, K, Wakatsuki, S. | | 登録日 | 2004-10-14 | | 公開日 | 2005-10-11 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural basis for recognition of ubiquitinated cargo by Tom1-GAT domain.
Febs Lett., 579, 2005
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3VHT
 | | Crystal structure of GFP-Wrnip1 UBZ domain fusion protein in complex with ubiquitin | | 分子名称: | Green fluorescent protein, Green fluorescent protein,ATPase WRNIP1, Ubiquitin, ... | | 著者 | Suzuki, N, Wakatsuki, S, Kawasaki, M. | | 登録日 | 2011-09-06 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1.
Febs J., 2016
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3VTW
 | | Crystal structure of T7-tagged Optineurin LIR-fused human LC3B_2-119 | | 分子名称: | Optineurin, microtubule-associated proteins 1A/1B light chain 3B, SULFATE ION | | 著者 | Suzuki, H, Kawasaki, M, Kato, R, Wakatsuki, S. | | 登録日 | 2012-06-08 | | 公開日 | 2013-06-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | Structural basis for phosphorylation-triggered autophagic clearance of Salmonella
Biochem.J., 454, 2013
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3VTU
 | | Crystal structure of human LC3B_2-119 | | 分子名称: | Microtubule-associated proteins 1A/1B light chain 3B, SULFATE ION | | 著者 | Suzuki, H, Kawasaki, M, Kato, R, Wakatsuki, S. | | 登録日 | 2012-06-08 | | 公開日 | 2013-06-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural basis for phosphorylation-triggered autophagic clearance of Salmonella
Biochem.J., 454, 2013
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3VHS
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8ZYO
 | | Cryo-EM Structure of astemizole-bound hERG Channel | | 分子名称: | 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine, Potassium voltage-gated channel subfamily H member 2 | | 著者 | Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. | | 登録日 | 2024-06-18 | | 公開日 | 2024-09-18 | | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | | 主引用文献 | Improved higher resolution Cryo-EM structures reveal the binding modes of hERG Channel Inhibitors
To Be Published
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8ZYN
 | | Cryo-EM Structure of inhibitor-free hERG Channel | | 分子名称: | Potassium voltage-gated channel subfamily H member 2 | | 著者 | Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. | | 登録日 | 2024-06-18 | | 公開日 | 2024-09-18 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Improved higher resolution Cryo-EM structures reveal the binding modes of hERG Channel Inhibitors
To Be Published
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8ZYQ
 | | Cryo-EM Structure of pimozide-bound hERG Channel | | 分子名称: | 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1~{H}-benzimidazol-2-one, Potassium voltage-gated channel subfamily H member 2 | | 著者 | Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. | | 登録日 | 2024-06-18 | | 公開日 | 2024-09-18 | | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | | 主引用文献 | Improved higher resolution Cryo-EM structures reveal the binding modes of hERG Channel Inhibitors
To Be Published
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8ZYP
 | | Cryo-EM Structure of E-4031-bound hERG Channel | | 分子名称: | Potassium voltage-gated channel subfamily H member 2, ~{N}-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidin-4-yl]carbonylphenyl]methanesulfonamide | | 著者 | Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. | | 登録日 | 2024-06-18 | | 公開日 | 2024-09-18 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Improved higher resolution Cryo-EM structures reveal the binding modes of hERG Channel Inhibitors
To Be Published
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8HW1
 | | Far-red light-harvesting complex of Antarctic alga Prasiola crispa | | 分子名称: | (1S)-4-[(1E,3Z,5E,7E,9E,11E,13E,15E,17E)-3-(hydroxymethyl)-7,12,16-trimethyl-18-[(1R,4S)-2,6,6-trimethyl-4-oxidanyl-cyclohex-2-en-1-yl]octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-3,5,5-trimethyl-cyclohex-3-en-1-ol, (3S,5R,6S,3'S,5'R,6'S)-5,6,5',6'-DIEPOXY-5,6,5',6'- TETRAHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, CHLOROPHYLL A, ... | | 著者 | Kosugi, M, Kawasaki, M, Shibata, Y, Moriya, T, Adachi, N, Senda, T. | | 登録日 | 2022-12-28 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | | 主引用文献 | Uphill energy transfer mechanism for photosynthesis in an Antarctic alga.
Nat Commun, 14, 2023
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5LRV
 | | Structure of Cezanne/OTUD7B OTU domain bound to Lys11-linked diubiquitin | | 分子名称: | GLYCEROL, OTU domain-containing protein 7B, PHOSPHATE ION, ... | | 著者 | Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D. | | 登録日 | 2016-08-22 | | 公開日 | 2016-10-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
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5LRU
 | | Structure of Cezanne/OTUD7B OTU domain | | 分子名称: | OTU domain-containing protein 7B | | 著者 | Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D. | | 登録日 | 2016-08-22 | | 公開日 | 2016-10-19 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
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