8Y6H

P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in LMNG detergent

Summary for 8Y6H

• Entry DOI: 10.2210/pdb8y6h/pdb
• EMDB information: 38986
• Descriptor: ATP-dependent translocase ABCB1,mNeonGreen, UIC2 Fab light chain, UIC2 Fab heavy chain, ... (4 entities in total)
• Functional Keywords: abc transporter, elacridar, p-glycoprotein, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 220929.06

Authors

Hamaguchi-Suzuki, N.,Adachi, N.,Moriya, T.,Kawasaki, M.,Suzuki, K.,Anzai, N.,Senda, T.,Murata, T. (deposition date: 2024-02-02, release date: 2024-04-17)

• Primary citation: Hamaguchi-Suzuki, N.,Adachi, N.,Moriya, T.,Yasuda, S.,Kawasaki, M.,Suzuki, K.,Ogasawara, S.,Anzai, N.,Senda, T.,Murata, T.; Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules.; Biochem.Biophys.Res.Commun., 709:149855-149855, 2024; PubMed: 38579618; DOI: 10.1016/j.bbrc.2024.149855

Experimental method

ELECTRON MICROSCOPY (2.49 Å)