8Y6H
P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in LMNG detergent
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | ATP-dependent translocase ABCB1,mNeonGreen | polymer | 1534 | 170535.8 | 1 | UniProt (P08183) UniProt (A0A1S4NYF2) Pfam (PF00664) Pfam (PF00005) In PDB | Homo sapiens (human) | ATP-binding cassette sub-family B member 1,Multidrug resistance protein 1,P-glycoprotein 1,Phospholipid transporter ABCB1 |
2 | B | UIC2 Fab light chain | polymer | 220 | 24321.0 | 1 | Mus musculus | ||
3 | C | UIC2 Fab heavy chain | polymer | 225 | 24381.3 | 1 | Mus musculus | ||
4 | A | elacridar | non-polymer | 563.6 | 3 | Chemie (R0Z) |
Sequence modifications
A: 1 - 1280 (UniProt: P08183)
A: 1293 - 1526 (UniProt: A0A1S4NYF2)
PDB | External Database | Details |
---|---|---|
Leu 1281 | - | linker |
Glu 1282 | - | linker |
Val 1283 | - | linker |
Leu 1284 | - | linker |
Phe 1285 | - | linker |
Gln 1286 | - | linker |
Gly 1287 | - | linker |
Pro 1288 | - | linker |
Arg 1289 | - | linker |
Pro 1290 | - | linker |
Arg 1291 | - | linker |
Gly 1292 | - | linker |
PDB | External Database | Details |
---|---|---|
His 1527 | - | expression tag |
His 1528 | - | expression tag |
His 1529 | - | expression tag |
His 1530 | - | expression tag |
His 1531 | - | expression tag |
His 1532 | - | expression tag |
His 1533 | - | expression tag |
His 1534 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 219238.1 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1690.9 | |
All* | Total formula weight | 220929.1 |