8Y6H

P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in LMNG detergent

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	ATP-dependent translocase ABCB1,mNeonGreen	polymer	1534	170535.8	1	UniProt (P08183) UniProt (A0A1S4NYF2) Pfam (PF00664) Pfam (PF00005)	Homo sapiens (human)	ATP-binding cassette sub-family B member 1,Multidrug resistance protein 1,P-glycoprotein 1,Phospholipid transporter ABCB1
2	B (B)	UIC2 Fab light chain	polymer	220	24321.0	1		Mus musculus
3	C (C)	UIC2 Fab heavy chain	polymer	225	24381.3	1		Mus musculus
4	D, E, F (A)	elacridar	non-polymer		563.6	3	Chemie (R0Z)

Sequence modifications

A: 1 - 1280 (UniProt: P08183)

PDB	External Database	Details
Leu 1281	-	linker
Glu 1282	-	linker
Val 1283	-	linker
Leu 1284	-	linker
Phe 1285	-	linker
Gln 1286	-	linker
Gly 1287	-	linker
Pro 1288	-	linker
Arg 1289	-	linker
Pro 1290	-	linker
Arg 1291	-	linker
Gly 1292	-	linker

A: 1293 - 1526 (UniProt: A0A1S4NYF2)

PDB	External Database	Details
His 1527	-	expression tag
His 1528	-	expression tag
His 1529	-	expression tag
His 1530	-	expression tag
His 1531	-	expression tag
His 1532	-	expression tag
His 1533	-	expression tag
His 1534	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	219238.1
Non-Polymers*	Number of molecules	3
	Total formula weight	1690.9
All*	Total formula weight	220929.1

*Water molecules are not included.