8Y6H
P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in LMNG detergent
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL |
| Chain | Residue | Details |
| A | LEU531-LEU545 | |
| A | LEU1176-LEU1190 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| B | TYR198-HIS204 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 901 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
| Chain | Residue | Details |
| A | MET1-ASN44 | |
| A | LEU138-ILE186 | |
| A | SER237-ALA292 | |
| A | GLU353-PHE711 | |
| A | GLY778-ARG832 | |
| A | GLU875-LYS934 | |
| A | PRO996-GLN1280 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 249 |
| Details | TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | TRP45-LEU67 | |
| A | TRP855-VAL874 | |
| A | ALA935-PHE957 | |
| A | VAL974-ALA995 | |
| A | TYR117-CYS137 | |
| A | GLY187-PHE208 | |
| A | LEU216-LEU236 | |
| A | ILE293-TYR316 | |
| A | VAL331-ILE352 | |
| A | VAL712-PHE732 | |
| A | LEU757-PHE777 | |
| A | LEU833-TYR853 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 106 |
| Details | TOPO_DOM: Extracellular => ECO:0000250 |
| Chain | Residue | Details |
| A | MET68-TYR116 | |
| A | THR209-THR215 | |
| A | GLY317-GLN330 | |
| A | SER733-SER756 | |
| A | GLY854 | |
| A | ARG958-ASP973 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 |
| Chain | Residue | Details |
| A | GLY427 | |
| A | GLY1070 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06795 |
| Chain | Residue | Details |
| A | SER660 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN91 | |
| A | ASN94 | |
| A | ASN99 |
