3D0V
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![BU of 3d0v by Molmil](/molmil-images/mine/3d0v) | Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide LLELDKWASLW | Descriptor: | 2F5 Fab heavy chain, 2F5 Fab light chain, gp41 peptide LLELDKWASLW | Authors: | Bryson, S, Julien, J.P, Pai, E.F. | Deposit date: | 2008-05-02 | Release date: | 2008-07-29 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site. J.Mol.Biol., 384, 2008
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6UUD
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![BU of 6uud by Molmil](/molmil-images/mine/6uud) | Crystal structure of antibody 5D5 in complex with PfCSP N-terminal peptide | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 5D5 Antibody Fab, ... | Authors: | Thai, E, Scally, S.W, Julien, J.P. | Deposit date: | 2019-10-30 | Release date: | 2020-07-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity. J.Exp.Med., 217, 2020
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6VLN
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![BU of 6vln by Molmil](/molmil-images/mine/6vln) | Crystal structure of 4498 Fab in complex with circumsporozoite protein DND3 and anti-Kappa VHH domain | Descriptor: | 4498 Fab heavy chain, 4498 Fab light chain, Circumsporozoite protein, ... | Authors: | Thai, E, Scally, S.W, Prieto, K, Murugan, R, Wardemann, H, Julien, J.P. | Deposit date: | 2020-01-24 | Release date: | 2020-06-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs. Nat. Med., 26, 2020
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6X4G
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![BU of 6x4g by Molmil](/molmil-images/mine/6x4g) | Crystal structure of ICOS in complex with ICOS-L and an anti ICOS-L VNAR domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ICOS ligand, ... | Authors: | Rujas, E, Sicard, T, Julien, J.P. | Deposit date: | 2020-05-22 | Release date: | 2020-10-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies. Nat Commun, 11, 2020
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6X4T
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![BU of 6x4t by Molmil](/molmil-images/mine/6x4t) | Crystal structure of ICOS-L in complex with Prezalumab and VNAR domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Rujas, E, Sicard, T, Julien, J.P. | Deposit date: | 2020-05-23 | Release date: | 2020-10-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies. Nat Commun, 11, 2020
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7RLZ
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![BU of 7rlz by Molmil](/molmil-images/mine/7rlz) | |
7RM1
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![BU of 7rm1 by Molmil](/molmil-images/mine/7rm1) | |
7RLW
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![BU of 7rlw by Molmil](/molmil-images/mine/7rlw) | |
7RLX
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![BU of 7rlx by Molmil](/molmil-images/mine/7rlx) | |
7RLV
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![BU of 7rlv by Molmil](/molmil-images/mine/7rlv) | |
7RLY
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![BU of 7rly by Molmil](/molmil-images/mine/7rly) | |
7RM0
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![BU of 7rm0 by Molmil](/molmil-images/mine/7rm0) | |
7RM3
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![BU of 7rm3 by Molmil](/molmil-images/mine/7rm3) | Antibody 2E10.E9 in complex with P. vivax CSP peptide ANGAGNQPGANGAGNQPGANGAGGQAA | Descriptor: | 2E10.E9 Fab heavy chain, 2E10.E9 Fab light chain, ACETATE ION, ... | Authors: | Kucharska, I, Ivanochko, D, Julien, J.P. | Deposit date: | 2021-07-26 | Release date: | 2022-01-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats. Elife, 11, 2022
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6WTS
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![BU of 6wts by Molmil](/molmil-images/mine/6wts) | CryoEM structure of the C. sordellii lethal toxin TcsL in complex with SEMA6A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SEMA6A, ... | Authors: | Kucharska, I, Rubinstein, J.L, Julien, J.P. | Deposit date: | 2020-05-03 | Release date: | 2020-07-08 | Last modified: | 2020-08-05 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins. Cell, 182, 2020
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6ULF
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![BU of 6ulf by Molmil](/molmil-images/mine/6ulf) | Crystal structure of 4498 Fab in complex with circumsporozoite protein NDN3 and anti-Kappa VHH domain | Descriptor: | 4498 Fab heavy chain, 4498 Fab light chain, Circumsporozoite protein, ... | Authors: | Thai, E, Scally, S.W, Prieto, K, Murugan, R, Wardemann, H, Julien, J.P. | Deposit date: | 2019-10-07 | Release date: | 2020-06-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs. Nat. Med., 26, 2020
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6WJL
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![BU of 6wjl by Molmil](/molmil-images/mine/6wjl) | Crystal structure of Glypican-2 core protein in complex with D3 Fab | Descriptor: | D3 Fab Heavy chain, D3 Fab Light Chain, Glypican-2, ... | Authors: | Raman, S, Maris, J.M, Bosse, K.R, Julien, J.P. | Deposit date: | 2020-04-14 | Release date: | 2021-04-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope. Cell Rep Med, 2, 2021
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6X87
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![BU of 6x87 by Molmil](/molmil-images/mine/6x87) | CryoEM structure of the Plasmodium berghei circumsporozoite protein in complex with inhibitory mouse antibody 3D11. | Descriptor: | 3D11 Fab heavy chain, 3D11 Fab kappa chain, Circumsporozoite protein | Authors: | Kucharska, I, Thai, E, Rubinstein, J, Julien, J.P. | Deposit date: | 2020-06-01 | Release date: | 2020-12-02 | Last modified: | 2020-12-16 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11. Elife, 9, 2020
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5VL3
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![BU of 5vl3 by Molmil](/molmil-images/mine/5vl3) | CD22 d1-d3 in complex with therapeutic Fab Epratuzumab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, B-cell receptor CD22, Epratuzumab Fab Heavy Chain, ... | Authors: | Sicard, T, Ereno-Orbea, J, Julien, J.P. | Deposit date: | 2017-04-24 | Release date: | 2017-10-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Molecular basis of human CD22 function and therapeutic targeting. Nat Commun, 8, 2017
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5VKK
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![BU of 5vkk by Molmil](/molmil-images/mine/5vkk) | |
7N0A
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![BU of 7n0a by Molmil](/molmil-images/mine/7n0a) | Structure of Human Leukaemia Inhibitory Factor with Fab MSC1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Leukemia inhibitory factor, ... | Authors: | Raman, S, Bosch, A, Fransson, J, Julien, J.P. | Deposit date: | 2021-05-25 | Release date: | 2022-06-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Therapeutic Targeting of LIF Overcomes Macrophage-mediated Immunosuppression of the Local Tumor Microenvironment. Clin.Cancer Res., 29, 2023
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7O52
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![BU of 7o52 by Molmil](/molmil-images/mine/7o52) | CD22 d6-d7 in complex with Fab m971 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CD22 d6-d7 Ig domains, GLYCEROL, ... | Authors: | Ereno-Orbea, J, Sicard, T, Julien, J.P. | Deposit date: | 2021-04-07 | Release date: | 2021-07-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Structural details of monoclonal antibody m971 recognition of the membrane-proximal domain of CD22. J.Biol.Chem., 297, 2021
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7O4Y
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![BU of 7o4y by Molmil](/molmil-images/mine/7o4y) | |
7OOI
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![BU of 7ooi by Molmil](/molmil-images/mine/7ooi) | Anti-EphA1 JD1 VH domain | Descriptor: | JD1 VH domain, SULFATE ION | Authors: | Ereno-Orbea, J, Nilvebrant, J, Sidhu, S, Julien, J.P. | Deposit date: | 2021-05-27 | Release date: | 2021-10-06 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Systematic Engineering of Optimized Autonomous Heavy-Chain Variable Domains. J.Mol.Biol., 433, 2021
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7OMN
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![BU of 7omn by Molmil](/molmil-images/mine/7omn) | Anti-EphA1 JD1-1 VH domain | Descriptor: | GLYCEROL, IMIDAZOLE, JD1-1 VH domain | Authors: | Ereno Orbea, J, Nilvebrant, J, Sidhu, S, Julien, J.P. | Deposit date: | 2021-05-24 | Release date: | 2021-10-06 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Systematic Engineering of Optimized Autonomous Heavy-Chain Variable Domains. J.Mol.Biol., 433, 2021
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6O26
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![BU of 6o26 by Molmil](/molmil-images/mine/6o26) | Crystal structure of 3246 Fab in complex with circumsporozoite protein NANA | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3246 Fab heavy chain, ... | Authors: | Scally, S.W, Bosch, A, Castro, K, Murugan, R, Wardemann, H, Julien, J.P. | Deposit date: | 2019-02-22 | Release date: | 2020-03-04 | Last modified: | 2020-09-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs. Nat. Med., 26, 2020
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