6WJL
Crystal structure of Glypican-2 core protein in complex with D3 Fab
Summary for 6WJL
Entry DOI | 10.2210/pdb6wjl/pdb |
Descriptor | Glypican-2, D3 Fab Heavy chain, VHH domain, ... (4 entities in total) |
Functional Keywords | neuroblastoma, oncoprotein, proteoglycan, therapeutic antibody, oncoprotein-immune system complex, oncoprotein/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 223432.67 |
Authors | Raman, S.,Maris, J.M.,Bosse, K.R.,Julien, J.P. (deposition date: 2020-04-14, release date: 2021-04-21, Last modification date: 2023-10-18) |
Primary citation | Raman, S.,Buongervino, S.N.,Lane, M.V.,Zhelev, D.V.,Zhu, Z.,Cui, H.,Martinez, B.,Martinez, D.,Wang, Y.,Upton, K.,Patel, K.,Rathi, K.S.,Navia, C.T.,Harmon, D.B.,Li, Y.,Pawel, B.,Dimitrov, D.S.,Maris, J.M.,Julien, J.P.,Bosse, K.R. A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope. Cell Rep Med, 2:100344-100344, 2021 Cited by PubMed: 34337560DOI: 10.1016/j.xcrm.2021.100344 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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