6WJL

Crystal structure of Glypican-2 core protein in complex with D3 Fab

Summary for 6WJL

• Entry DOI: 10.2210/pdb6wjl/pdb
• Descriptor: Glypican-2, D3 Fab Heavy chain, VHH domain, ... (4 entities in total)
• Functional Keywords: neuroblastoma, oncoprotein, proteoglycan, therapeutic antibody, oncoprotein-immune system complex, oncoprotein/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 223432.67

Authors

Raman, S.,Maris, J.M.,Bosse, K.R.,Julien, J.P. (deposition date: 2020-04-14, release date: 2021-04-21, Last modification date: 2023-10-18)

• Primary citation: Raman, S.,Buongervino, S.N.,Lane, M.V.,Zhelev, D.V.,Zhu, Z.,Cui, H.,Martinez, B.,Martinez, D.,Wang, Y.,Upton, K.,Patel, K.,Rathi, K.S.,Navia, C.T.,Harmon, D.B.,Li, Y.,Pawel, B.,Dimitrov, D.S.,Maris, J.M.,Julien, J.P.,Bosse, K.R.; A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope.; Cell Rep Med, 2:100344-100344, 2021; PubMed: 34337560; DOI: 10.1016/j.xcrm.2021.100344

Experimental method

X-RAY DIFFRACTION (3.3 Å)