6WJL

Crystal structure of Glypican-2 core protein in complex with D3 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (G, E)	Glypican-2	polymer	482	53427.7	2	UniProt (Q8N158) Pfam (PF01153)	Homo sapiens (Human)
2	B, F (H, F)	D3 Fab Heavy chain	polymer	220	23499.2	2		Homo sapiens
3	C, G (K, I)	VHH domain	polymer	121	11326.3	2		Lama glama
4	D, H (L, J)	D3 Fab Light Chain	polymer	214	23463.1	2		Homo sapiens

Sequence modifications

G, E: 23 - 493 (UniProt: Q8N158)

PDB	External Database	Details
Glu 21	-	expression tag
Thr 22	-	expression tag
Thr 55	Ser 55	engineered mutation
Thr 92	Ser 92	engineered mutation
Thr 155	Ser 155	engineered mutation
Gly 494	-	expression tag
Thr 495	-	expression tag
Lys 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag
His 499	-	expression tag
His 500	-	expression tag
His 501	-	expression tag
His 502	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	223432.7
All*	Total formula weight	223432.7

*Water molecules are not included.