3OL2
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![BU of 3ol2 by Molmil](/molmil-images/mine/3ol2) | Receptor-ligand structure of Human Semaphorin 4D with Plexin B1. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Plexin-B1, ... | 著者 | Janssen, B.J.C, Robinson, R.A, Perez-Branguli, F, Bell, C.H, Mitchell, C.J, Siebold, C, Jones, E.Y. | 登録日 | 2010-08-25 | 公開日 | 2010-10-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Structural basis of semaphorin-plexin signalling. Nature, 467, 2010
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3P5J
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3P87
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![BU of 3p87 by Molmil](/molmil-images/mine/3p87) | Structure of human PCNA bound to RNASEH2B PIP box peptide | 分子名称: | Proliferating cell nuclear antigen, Ribonuclease H2 subunit B | 著者 | Bubeck, D, Reijns, M.A, Graham, S.C, Astell, K.R, Jones, E.Y, Jackson, A.P. | 登録日 | 2010-10-13 | 公開日 | 2011-02-02 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | PCNA directs type 2 RNase H activity on DNA replication and repair substrates. Nucleic Acids Res., 39, 2011
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3OKT
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![BU of 3okt by Molmil](/molmil-images/mine/3okt) | Mouse Plexin A2, extracellular domains 1-4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | 著者 | Janssen, B.J.C, Robinson, R.A, Bell, C.H, Siebold, C, Jones, E.Y. | 登録日 | 2010-08-25 | 公開日 | 2010-10-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.296 Å) | 主引用文献 | Structural basis of semaphorin-plexin signalling. Nature, 467, 2010
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3OKW
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![BU of 3okw by Molmil](/molmil-images/mine/3okw) | Mouse Semaphorin 6A, extracellular domains 1-2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, ... | 著者 | Janssen, B.J.C, Robinson, R.A, Bell, C.H, Siebold, C, Jones, E.Y. | 登録日 | 2010-08-25 | 公開日 | 2010-10-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.299 Å) | 主引用文献 | Structural basis of semaphorin-plexin signalling. Nature, 467, 2010
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3P83
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![BU of 3p83 by Molmil](/molmil-images/mine/3p83) | Structure of the PCNA:RNase HII complex from Archaeoglobus fulgidus. | 分子名称: | DNA polymerase sliding clamp, Ribonuclease HII | 著者 | Bubeck, D, Reijns, M.A, Graham, S.C, Astell, K.R, Jones, E.Y, Jackson, A.P. | 登録日 | 2010-10-13 | 公開日 | 2011-02-02 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | PCNA directs type 2 RNase H activity on DNA replication and repair substrates. Nucleic Acids Res., 39, 2011
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3OKY
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![BU of 3oky by Molmil](/molmil-images/mine/3oky) | Plexin A2 in complex with Semaphorin 6A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | 著者 | Janssen, B.J.C, Robinson, R.A, Bell, C.H, Siebold, C, Jones, E.Y. | 登録日 | 2010-08-25 | 公開日 | 2010-10-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.195 Å) | 主引用文献 | Structural basis of semaphorin-plexin signalling. Nature, 467, 2010
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2L2A
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![BU of 2l2a by Molmil](/molmil-images/mine/2l2a) | Mutated Domain 11 of the Cytoplasmic region of the Cation-independent mannose-6-phosphate receptor | 分子名称: | Insulin-like growth factor 2 receptor variant | 著者 | Williams, C, Hoppe, H, Rezgui, D, Strickland, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Crump, M.P, Hassan, A.B. | 登録日 | 2010-08-13 | 公開日 | 2012-02-15 | 最終更新日 | 2012-12-12 | 実験手法 | SOLUTION NMR | 主引用文献 | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution. Science, 338, 2012
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2L2G
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![BU of 2l2g by Molmil](/molmil-images/mine/2l2g) | Solution structure of Opossum Domain 11 | 分子名称: | IGF2R DOMAIN 11 | 著者 | Williams, C, Hoppe, H, Rezgui, D, Rezgui, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Crump, M.P, Bassim, A.H. | 登録日 | 2010-08-18 | 公開日 | 2012-02-15 | 最終更新日 | 2015-02-25 | 実験手法 | SOLUTION NMR | 主引用文献 | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution. Science, 338, 2012
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6RZ3
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![BU of 6rz3 by Molmil](/molmil-images/mine/6rz3) | Crystal structure of a complex between the DNA-binding domain of p53 and the carboxyl-terminal conserved region of iASPP | 分子名称: | Cellular tumor antigen p53, RelA-associated inhibitor, ZINC ION | 著者 | Chen, S, Ren, J, Jones, E.Y, Lu, X. | 登録日 | 2019-06-12 | 公開日 | 2019-10-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (4.23 Å) | 主引用文献 | iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition. Proc.Natl.Acad.Sci.USA, 116, 2019
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4UFS
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6S9F
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![BU of 6s9f by Molmil](/molmil-images/mine/6s9f) | Drosophila OTK, extracellular domains 3-5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Tyrosine-protein kinase-like otk | 著者 | Rozbesky, D, Jones, E.Y. | 登録日 | 2019-07-12 | 公開日 | 2020-03-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.969 Å) | 主引用文献 | Drosophila OTK Is a Glycosaminoglycan-Binding Protein with High Conformational Flexibility. Structure, 28, 2020
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6SNW
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![BU of 6snw by Molmil](/molmil-images/mine/6snw) | Structure of Coxsackievirus A10 complexed with its receptor KREMEN1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein VP1, Capsid protein VP3, ... | 著者 | Zhao, Y, Zhou, D, Ni, T, Karia, D, Kotecha, A, Wang, X, Rao, Z, Jones, E.Y, Fry, E.E, Ren, J, Stuart, D.I. | 登録日 | 2019-08-27 | 公開日 | 2020-01-15 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10. Nat Commun, 11, 2020
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6SNB
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![BU of 6snb by Molmil](/molmil-images/mine/6snb) | Structure of Coxsackievirus A10 A-particle | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 | 著者 | Zhao, Y, Zhou, D, Ni, T, Karia, D, Kotecha, A, Wang, X, Rao, Z, Jones, E.Y, Fry, E.E, Ren, J, Stuart, D.I. | 登録日 | 2019-08-23 | 公開日 | 2020-01-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10. Nat Commun, 11, 2020
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6TFM
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![BU of 6tfm by Molmil](/molmil-images/mine/6tfm) | Frizzled8 CRD | 分子名称: | Frizzled-8 | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2019-11-14 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.343 Å) | 主引用文献 | Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8. J.Med.Chem., 63, 2020
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6T2H
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![BU of 6t2h by Molmil](/molmil-images/mine/6t2h) | Furano[2,3-d]prymidine amides as Notum inhibitors | 分子名称: | 1,2-ETHANEDIOL, 2-[[(4~{S})-5-chloranyl-6-methyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-4-yl]sulfanyl]ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2019-10-08 | 公開日 | 2020-01-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors. Bioorg.Med.Chem.Lett., 30, 2020
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6TFB
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![BU of 6tfb by Molmil](/molmil-images/mine/6tfb) | Carbamazepine binds Frizzled8 | 分子名称: | Frizzled-8, GLYCEROL, benzo[b][1]benzazepine-11-carboxamide | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2019-11-13 | 公開日 | 2020-02-26 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8. J.Med.Chem., 63, 2020
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6T2K
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![BU of 6t2k by Molmil](/molmil-images/mine/6t2k) | Furano[2,3-d]prymidine amides as Notum inhibitors | 分子名称: | 1,2-ETHANEDIOL, 2-(6-chloranyl-7-cyclopropyl-thieno[3,2-d]pyrimidin-4-yl)sulfanylethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2019-10-08 | 公開日 | 2020-01-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors. Bioorg.Med.Chem.Lett., 30, 2020
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6SMG
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![BU of 6smg by Molmil](/molmil-images/mine/6smg) | Structure of Coxsackievirus A10 | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | 著者 | Zhao, Y, Zhou, D, Ni, T, Karia, D, Kotecha, A, Wang, X, Rao, Z, Jones, E.Y, Fry, E.E, Ren, J, Stuart, D.I. | 登録日 | 2019-08-21 | 公開日 | 2020-01-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10. Nat Commun, 11, 2020
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1LQB
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![BU of 1lqb by Molmil](/molmil-images/mine/1lqb) | Crystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex | 分子名称: | Elongin B, Elongin C, Hypoxia-inducible factor 1 ALPHA, ... | 著者 | Hon, W.C, Wilson, M.I, Harlos, K, Claridge, T.D, Schofield, C.J, Pugh, C.W, Maxwell, P.H, Ratcliffe, P.J, Stuart, D.I, Jones, E.Y. | 登録日 | 2002-05-09 | 公開日 | 2002-07-03 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature, 417, 2002
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1LMW
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![BU of 1lmw by Molmil](/molmil-images/mine/1lmw) | LMW U-PA Structure complexed with EGRCMK (GLU-GLY-ARG Chloromethyl Ketone) | 分子名称: | L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, UROKINASE-TYPE PLASMINOGEN ACTIVATOR | 著者 | Spraggon, G.S, Phillips, C, Nowak, U.K, Ponting, C.P, Saunders, D, Dobson, C.M, Stuart, D.I, Jones, E.Y. | 登録日 | 1995-07-26 | 公開日 | 1996-01-29 | 最終更新日 | 2013-02-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The crystal structure of the catalytic domain of human urokinase-type plasminogen activator. Structure, 3, 1995
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6TV4
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![BU of 6tv4 by Molmil](/molmil-images/mine/6tv4) | CFF-Notum complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CAFFEINE, DIMETHYL SULFOXIDE, ... | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2020-01-08 | 公開日 | 2020-10-28 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Caffeine inhibits Notum activity by binding at the catalytic pocket. Commun Biol, 3, 2020
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8BT7
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![BU of 8bt7 by Molmil](/molmil-images/mine/8bt7) | Notum Inhibitor ARUK3004903 | 分子名称: | 1,2-ETHANEDIOL, 1-[3,4-bis(chloranyl)-5-methyl-indol-1-yl]ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhao, Y, Jones, E.Y, Fish, P. | 登録日 | 2022-11-28 | 公開日 | 2022-12-14 | 最終更新日 | 2023-06-28 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity. Eur.J.Med.Chem., 251, 2023
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8BTC
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![BU of 8btc by Molmil](/molmil-images/mine/8btc) | Notum Inhibitor ARUK3004558 | 分子名称: | 1,2-ETHANEDIOL, 1-[4,5-bis(chloranyl)-2,3-dihydroindol-1-yl]ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhao, Y, Jones, E.Y, Fish, P. | 登録日 | 2022-11-28 | 公開日 | 2022-12-14 | 最終更新日 | 2023-06-28 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity. Eur.J.Med.Chem., 251, 2023
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8BT5
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![BU of 8bt5 by Molmil](/molmil-images/mine/8bt5) | Notum Inhibitor ARUK3004877 | 分子名称: | 1,2-ETHANEDIOL, 1-(4-fluoranylspiro[2~{H}-indole-3,1'-cyclobutane]-1-yl)ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhao, Y, Jones, E.Y, Fish, P. | 登録日 | 2022-11-27 | 公開日 | 2022-12-14 | 最終更新日 | 2023-06-28 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity. Eur.J.Med.Chem., 251, 2023
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