6T2K
Furano[2,3-d]prymidine amides as Notum inhibitors
Summary for 6T2K
| Entry DOI | 10.2210/pdb6t2k/pdb |
| Descriptor | Palmitoleoyl-protein carboxylesterase NOTUM, SULFATE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
| Functional Keywords | substrate, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 44817.73 |
| Authors | Zhao, Y.,Jones, E.Y. (deposition date: 2019-10-08, release date: 2020-01-01, Last modification date: 2024-01-24) |
| Primary citation | Atkinson, B.N.,Steadman, D.,Mahy, W.,Zhao, Y.,Sipthorp, J.,Bayle, E.D.,Svensson, F.,Papageorgiou, G.,Jeganathan, F.,Frew, S.,Monaghan, A.,Bictash, M.,Jones, E.Y.,Fish, P.V. Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors. Bioorg.Med.Chem.Lett., 30:126751-126751, 2020 Cited by PubMed: 31862412DOI: 10.1016/j.bmcl.2019.126751 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.38 Å) |
Structure validation
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