Structure of human PCNA bound to RNASEH2B PIP box peptide

Summary for 3P87

Related3P83 1AXC
DescriptorProliferating cell nuclear antigen, Ribonuclease H2 subunit B (2 entities in total)
Functional Keywordsdna binding, dna replication, dna repair, sliding clamp, pcna peptide interacting peptide (pip) motif, pip-box motif, dna clamp, processivity factor, rnase h2, fen-1, ligase, polymerases, helicases, nucleases, nucleus, hydrolase-dna binding protein complex, hydrolase/dna binding protein
Biological sourceHomo sapiens (human)
Cellular locationNucleus P12004
Nucleus (Probable) Q5TBB1
Total number of polymer chains12
Total molecular weight188153.04
Bubeck, D.,Reijns, M.A.,Graham, S.C.,Astell, K.R.,Jones, E.Y.,Jackson, A.P. (deposition date: 2010-10-13, release date: 2011-02-02, Last modification date: 2014-04-02)
Primary citation
Bubeck, D.,Reijns, M.A.,Graham, S.C.,Astell, K.R.,Jones, E.Y.,Jackson, A.P.
PCNA directs type 2 RNase H activity on DNA replication and repair substrates.
Nucleic Acids Res., 39:3652-3666, 2011
PubMed: 21245041 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkq980
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2666 0.8% 4.5% 4.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02