6TFB

Carbamazepine binds Frizzled8

Summary for 6TFB

Entry DOI	10.2210/pdb6tfb/pdb
Descriptor	Frizzled-8, GLYCEROL, benzo[b][1]benzazepine-11-carboxamide, ... (4 entities in total)
Functional Keywords	wnt receptor frizzled8 carbamazepine, oncoprotein
Biological source	Mus musculus (Mouse)
Total number of polymer chains	2
Total formula weight	32378.98
Authors	Zhao, Y.,Jones, E.Y. (deposition date: 2019-11-13, release date: 2020-02-26, Last modification date: 2024-01-24)
Primary citation	Zhao, Y.,Ren, J.,Hillier, J.,Lu, W.,Jones, E.Y. Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8. J.Med.Chem., 63:3252-3260, 2020 Cited by PubMed: 32049522 DOI: 10.1021/acs.jmedchem.9b02020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.68 Å)

Structure validation