6T2H

Furano[2,3-d]prymidine amides as Notum inhibitors

Summary for 6T2H

Entry DOI	10.2210/pdb6t2h/pdb
Descriptor	Palmitoleoyl-protein carboxylesterase NOTUM, DIMETHYL SULFOXIDE, SULFATE ION, ... (7 entities in total)
Functional Keywords	substrate, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	45702.73
Authors	Zhao, Y.,Jones, E.Y. (deposition date: 2019-10-08, release date: 2020-01-01, Last modification date: 2024-01-24)
Primary citation	Atkinson, B.N.,Steadman, D.,Mahy, W.,Zhao, Y.,Sipthorp, J.,Bayle, E.D.,Svensson, F.,Papageorgiou, G.,Jeganathan, F.,Frew, S.,Monaghan, A.,Bictash, M.,Jones, E.Y.,Fish, P.V. Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors. Bioorg.Med.Chem.Lett., 30:126751-126751, 2020 Cited by PubMed: 31862412 DOI: 10.1016/j.bmcl.2019.126751 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.41 Å)

Structure validation