6T2H
Furano[2,3-d]prymidine amides as Notum inhibitors
Summary for 6T2H
Entry DOI | 10.2210/pdb6t2h/pdb |
Descriptor | Palmitoleoyl-protein carboxylesterase NOTUM, DIMETHYL SULFOXIDE, SULFATE ION, ... (7 entities in total) |
Functional Keywords | substrate, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 45702.73 |
Authors | Zhao, Y.,Jones, E.Y. (deposition date: 2019-10-08, release date: 2020-01-01, Last modification date: 2024-01-24) |
Primary citation | Atkinson, B.N.,Steadman, D.,Mahy, W.,Zhao, Y.,Sipthorp, J.,Bayle, E.D.,Svensson, F.,Papageorgiou, G.,Jeganathan, F.,Frew, S.,Monaghan, A.,Bictash, M.,Jones, E.Y.,Fish, P.V. Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors. Bioorg.Med.Chem.Lett., 30:126751-126751, 2020 Cited by PubMed: 31862412DOI: 10.1016/j.bmcl.2019.126751 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.41 Å) |
Structure validation
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