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PDB: 109 件
6QZK
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BU of 6qzk by Molmil
Structure of Clostridium butyricum Argonaute bound to a guide DNA (5' deoxycytidine) and a 19-mer target DNA
分子名称: Clostridium butyricum Argonaute, DNA target (5'-D(T*AP*TP*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*T)-3'), FORMIC ACID, ...
著者Swarts, D.C, Jinek, M, Hegge, J.W, Van der Oost, J.
登録日2019-03-11
公開日2019-04-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.548 Å)
主引用文献DNA-guided DNA cleavage at moderate temperatures by Clostridium butyricum Argonaute.
Nucleic Acids Res., 47, 2019
5AF2
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BU of 5af2 by Molmil
Crystal structure of the C-terminal 2',5'-phosphodiesterase domain of group A rotavirus protein VP3
分子名称: POLYETHYLENE GLYCOL (N=34), POTASSIUM ION, VP3
著者Brandmann, T, Jinek, M.
登録日2015-01-16
公開日2015-03-18
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献Crystal Structure of the C-Terminal 2',5'-Phosphodiesterase Domain of Group a Rotavirus Protein Vp3.
Proteins, 83, 2015
5L6D
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BU of 5l6d by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to SAH
分子名称: ACETATE ION, MAGNESIUM ION, N6-adenosine-methyltransferase 70 kDa subunit, ...
著者Sledz, P, Jinek, M.
登録日2016-05-29
公開日2016-10-12
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (1.852 Å)
主引用文献Structural insights into the molecular mechanism of the m(6)A writer complex.
Elife, 5, 2016
5L6E
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BU of 5l6e by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to SAM
分子名称: ACETATE ION, MAGNESIUM ION, N6-adenosine-methyltransferase 70 kDa subunit, ...
著者Sledz, P, Jinek, M.
登録日2016-05-29
公開日2016-10-12
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (1.901 Å)
主引用文献Structural insights into the molecular mechanism of the m(6)A writer complex.
Elife, 5, 2016
4UN3
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BU of 4un3 by Molmil
Crystal structure of Cas9 bound to PAM-containing DNA target
分子名称: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ...
著者Anders, C, Niewoehner, O, Duerst, A, Jinek, M.
登録日2014-05-25
公開日2014-07-23
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.593 Å)
主引用文献Structural Basis of Pam-Dependent Target DNA Recognition by the Cas9 Endonuclease
Nature, 513, 2014
4UN5
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BU of 4un5 by Molmil
Crystal structure of Cas9 bound to PAM-containing DNA target containing mismatches at positions 1-3
分子名称: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ...
著者Anders, C, Niewoehner, O, Duerst, A, Jinek, M.
登録日2014-05-25
公開日2014-07-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Basis of Pam-Dependent Target DNA Recognition by the Cas9 Endonuclease
Nature, 513, 2014
4UN4
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BU of 4un4 by Molmil
Crystal structure of Cas9 bound to PAM-containing DNA target with mismatches at positions 1-2
分子名称: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ...
著者Anders, C, Niewoehner, O, Duerst, A, Jinek, M.
登録日2014-05-25
公開日2014-07-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.371 Å)
主引用文献Structural Basis of Pam-Dependent Target DNA Recognition by the Cas9 Endonuclease
Nature, 513, 2014
3P2Q
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BU of 3p2q by Molmil
Crystal structure of the fluoroacetyl-CoA-specific thioesterase, FlK
分子名称: Fluoroacetyl coenzyme A thioesterase
著者Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y.
登録日2010-10-03
公開日2010-10-20
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity.
Biochemistry, 49, 2010
3P3F
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BU of 3p3f by Molmil
Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK
分子名称: Fluoroacetyl coenzyme A thioesterase
著者Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y.
登録日2010-10-04
公開日2010-10-20
最終更新日2011-11-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity.
Biochemistry, 49, 2010
5NG6
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BU of 5ng6 by Molmil
Crystal structure of FnCas12a bound to a crRNA
分子名称: CRISPR-associated endonuclease Cpf1, MAGNESIUM ION, crRNA
著者Swarts, D.C, van der Oost, J, Jinek, M.
登録日2017-03-16
公開日2017-06-14
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (3.342 Å)
主引用文献Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a.
Mol. Cell, 66, 2017
5NFV
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BU of 5nfv by Molmil
Crystal structure of catalytically inactive FnCas12 mutant bound to an R-loop structure containing a pre-crRNA mimic and full-length DNA target
分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CRISPR-associated endonuclease Cpf1, DNA non-target strand, ...
著者Swarts, D.C, van der Oost, J, Jinek, M.
登録日2017-03-16
公開日2017-06-14
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a.
Mol. Cell, 66, 2017
5FQ5
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BU of 5fq5 by Molmil
Crystal structure of Cas9-sgRNA-DNA complex solved by native SAD phasing
分子名称: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ...
著者Olieric, V, Weinert, T, Finke, A, Anders, C, Jinek, M, Wang, M.
登録日2015-12-07
公開日2016-03-23
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.136 Å)
主引用文献Data-Collection Strategy for Challenging Native Sad Phasing.
Acta Crystallogr.,Sect.D, 72, 2016
5FW2
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BU of 5fw2 by Molmil
Crystal structure of SpCas9 variant EQR bound to sgRNA and TGAG PAM target DNA
分子名称: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ...
著者Anders, C, Bargsten, K, Jinek, M.
登録日2016-02-11
公開日2016-06-15
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.676 Å)
主引用文献Structural Plasticity of Pam Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.
Mol.Cell, 61, 2016
5FW3
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BU of 5fw3 by Molmil
Crystal structure of SpCas9 variant VRER bound to sgRNA and TGCG PAM target DNA
分子名称: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ...
著者Anders, C, Bargsten, K, Jinek, M.
登録日2016-02-11
公開日2016-06-15
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Plasticity of Pam Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.
Mol.Cell, 61, 2016
3P3I
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BU of 3p3i by Molmil
Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate and CoA
分子名称: COENZYME A, Fluoroacetyl coenzyme A thioesterase, fluoroacetic acid
著者Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y.
登録日2010-10-04
公開日2010-10-20
最終更新日2011-11-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity.
Biochemistry, 49, 2010
3P2R
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BU of 3p2r by Molmil
Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate
分子名称: Fluoroacetyl coenzyme A thioesterase, fluoroacetic acid
著者Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y.
登録日2010-10-03
公開日2010-10-20
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity.
Biochemistry, 49, 2010
3P2S
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BU of 3p2s by Molmil
Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in an open conformation
分子名称: Fluoroacetyl coenzyme A thioesterase
著者Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y.
登録日2010-10-04
公開日2010-10-20
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity.
Biochemistry, 49, 2010
6I0U
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BU of 6i0u by Molmil
Crystal structure of DmTailor in complex with U6 RNA
分子名称: MAGNESIUM ION, RNA (5'-R(*UP*UP*UP*U)-3'), Terminal uridylyltransferase Tailor
著者Kroupova, A, Ivascu, A, Jinek, M.
登録日2018-10-26
公開日2018-12-05
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.001 Å)
主引用文献Structural basis for acceptor RNA substrate selectivity of the 3' terminal uridylyl transferase Tailor.
Nucleic Acids Res., 47, 2019
5FW1
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BU of 5fw1 by Molmil
Crystal structure of SpyCas9 variant VQR bound to sgRNA and TGAG PAM target DNA
分子名称: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ...
著者Anders, C, Bargsten, K, Jinek, M.
登録日2016-02-11
公開日2016-04-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.499 Å)
主引用文献Structural Plasticity of Pam Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.
Mol.Cell, 61, 2016
6TUG
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BU of 6tug by Molmil
Enterococcus italicus Csm6 bound to cyclic hexa-2'-fluoro-hexa-dAMP
分子名称: 2'-deoxy-2'-fluoroadenosine 5'-(dihydrogen phosphate), CRISPR system endoribonuclease Csm6, SULFATE ION
著者Garcia-Doval, C, Jinek, M.
登録日2020-01-07
公開日2020-02-26
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6.
Nat Commun, 11, 2020
5FSH
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BU of 5fsh by Molmil
Crystal structure of Thermus thermophilus Csm6
分子名称: CSM6, NICKEL (II) ION
著者Niewoehner, O, Jinek, M.
登録日2016-01-06
公開日2016-01-27
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献Structural Basis for the Endoribonuclease Activity of the Type III-A Crispr-Associated Protein Csm6.
RNA, 22, 2016
6RVZ
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BU of 6rvz by Molmil
Crystal structure of ANGEL2, a 2',3'-cyclic phosphatase, in complex with adenosine-2',3'-vanadate
分子名称: ADENOSINE, MAGNESIUM ION, POTASSIUM ION, ...
著者Kroupova, A, Jinek, M.
登録日2019-06-03
公開日2020-05-20
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.
Science, 369, 2020
6RW0
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BU of 6rw0 by Molmil
Crystal structure of ANGEL2, a 2',3'-cyclic phosphatase
分子名称: GLYCEROL, MAGNESIUM ION, POTASSIUM ION, ...
著者Kroupova, A, Jinek, M.
登録日2019-06-03
公開日2020-05-20
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.
Science, 369, 2020
3ICQ
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BU of 3icq by Molmil
Karyopherin nuclear state
分子名称: Exportin-T, GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Cook, A.G, Fukuhara, N, Jinek, M, Conti, E.
登録日2009-07-18
公開日2009-08-25
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structures of the tRNA export factor in the nuclear and cytosolic states
Nature, 461, 2009
3IBV
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BU of 3ibv by Molmil
Karyopherin cytosolic state
分子名称: CALCIUM ION, Exportin-T
著者Cook, A.G, Fukuhara, N, Jinek, M, Conti, E.
登録日2009-07-17
公開日2009-08-25
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structures of the tRNA export factor in the nuclear and cytosolic states
Nature, 461, 2009

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