2Q0O
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![BU of 2q0o by Molmil](/molmil-images/mine/2q0o) | Crystal structure of an anti-activation complex in bacterial quorum sensing | Descriptor: | 3-OXO-OCTANOIC ACID (2-OXO-TETRAHYDRO-FURAN-3-YL)-AMIDE, Probable transcriptional activator protein traR, Probable transcriptional repressor traM | Authors: | Chen, G, Jeffrey, P.D, Fuqua, C, Shi, Y, Chen, L. | Deposit date: | 2007-05-22 | Release date: | 2007-09-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for antiactivation in bacterial quorum sensing. Proc.Natl.Acad.Sci.Usa, 104, 2007
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1JST
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![BU of 1jst by Molmil](/molmil-images/mine/1jst) | PHOSPHORYLATED CYCLIN-DEPENDENT KINASE-2 BOUND TO CYCLIN A | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CYCLIN A, CYCLIN-DEPENDENT KINASE-2, ... | Authors: | Russo, A.A, Jeffrey, P.D, Pavletich, N.P. | Deposit date: | 1996-07-03 | Release date: | 1997-01-11 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of cyclin-dependent kinase activation by phosphorylation. Nat.Struct.Biol., 3, 1996
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4M9R
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![BU of 4m9r by Molmil](/molmil-images/mine/4m9r) | Crystal structure of CED-3 | Descriptor: | Cell death protein 3 | Authors: | Xu, Y, Jeffrey, P.D, Shi, Y.G. | Deposit date: | 2013-08-15 | Release date: | 2013-10-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.656 Å) | Cite: | Mechanistic insights into CED-4-mediated activation of CED-3 Genes Dev., 27, 2013
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4L9O
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![BU of 4l9o by Molmil](/molmil-images/mine/4l9o) | Crystal Structure of the Sec13-Sec16 blade-inserted complex from Pichia pastoris | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... | Authors: | McMahon, C, Jeffrey, P.D, Hughson, F.M. | Deposit date: | 2013-06-18 | Release date: | 2013-10-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Sec16 influences transitional ER sites by regulating rather than organizing COPII. Mol Biol Cell, 24, 2013
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7LTB
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![BU of 7ltb by Molmil](/molmil-images/mine/7ltb) | Crystal Structure of Keratinicyclin B | Descriptor: | (2~{S},4~{S},5~{R},6~{S})-4-azanyl-5-methoxy-6-methyl-oxan-2-ol, 3-ammonio-2,3,6-trideoxy-alpha-L-arabino-hexopyranose-(1-2)-beta-D-glucopyranose, FORMIC ACID, ... | Authors: | Davis, K.M, Jeffrey, P.D, Seyedsayamdost, M.R. | Deposit date: | 2021-02-19 | Release date: | 2022-12-07 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | Structural and Functional Analysis of Keratinicyclin Reveals Synergistic Antibiosis with Vancomycin against Clostridium difficile to be published
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7LKC
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![BU of 7lkc by Molmil](/molmil-images/mine/7lkc) | Crystal Structure of Keratinimicin A | Descriptor: | (2~{S},4~{S},5~{R},6~{S})-4-azanyl-5-methoxy-6-methyl-oxan-2-ol, CHLORIDE ION, FORMIC ACID, ... | Authors: | Davis, K.M, Jeffrey, P.D, Seyedsayamdost, M.R. | Deposit date: | 2021-02-02 | Release date: | 2022-12-07 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | Structural and Functional Analysis of Keratinicyclin Reveals Synergistic Antibiosis with Vancomycin against Clostridium difficile to be published
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1TUP
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![BU of 1tup by Molmil](/molmil-images/mine/1tup) | TUMOR SUPPRESSOR P53 COMPLEXED WITH DNA | Descriptor: | DNA (5'-D(*AP*TP*AP*AP*TP*TP*GP*GP*GP*CP*AP*AP*GP*TP*CP*TP*A P*GP*GP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*CP*CP*TP*AP*GP*AP*CP*TP*TP*GP*CP*CP*CP*A P*AP*TP*TP*A)-3'), PROTEIN (P53 TUMOR SUPPRESSOR ), ... | Authors: | Cho, Y, Gorina, S, Jeffrey, P.D, Pavletich, N.P. | Deposit date: | 1995-07-11 | Release date: | 1995-07-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science, 265, 1994
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1SHW
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![BU of 1shw by Molmil](/molmil-images/mine/1shw) | EphB2 / EphrinA5 Complex Structure | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-B receptor 2, Ephrin-A5, ... | Authors: | Himanen, J.P, Chumley, M.J, Lackmann, M, Li, C, Barton, W.A, Jeffrey, P.D, Vearing, C, Geleick, D, Feldheim, D.A, Boyd, A.W. | Deposit date: | 2004-02-26 | Release date: | 2004-05-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling Nat.Neurosci., 7, 2004
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1T4W
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![BU of 1t4w by Molmil](/molmil-images/mine/1t4w) | Structural Differences in the DNA Binding Domains of Human p53 and its C. elegans Ortholog Cep-1: Structure of C. elegans Cep-1 | Descriptor: | C.Elegans p53 tumor suppressor-like transcription factor, ZINC ION | Authors: | Huyen, Y, Jeffrey, P.D, Derry, W.B, Rothman, J.H, Pavletich, N.P, Stavridi, E.S, Halazonetis, T.D. | Deposit date: | 2004-04-30 | Release date: | 2004-07-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Differences in the DNA Binding Domains of Human p53 and Its C. elegans Ortholog Cep-1. Structure, 12, 2004
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1IIM
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![BU of 1iim by Molmil](/molmil-images/mine/1iim) | thymidylyltransferase complexed with TTP | Descriptor: | THYMIDINE-5'-TRIPHOSPHATE, glucose-1-phosphate thymidylyltransferase | Authors: | Barton, W.A, Lesniak, J, Biggins, J.B, Jeffrey, P.D, Jiang, J, Rajashankar, K.R, Thorson, J.S, Nikolov, D.B. | Deposit date: | 2001-04-23 | Release date: | 2001-05-09 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization. Nat.Struct.Biol., 8, 2001
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1JSU
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![BU of 1jsu by Molmil](/molmil-images/mine/1jsu) | P27(KIP1)/CYCLIN A/CDK2 COMPLEX | Descriptor: | CYCLIN A, CYCLIN-DEPENDENT KINASE-2, P27, ... | Authors: | Russo, A.A, Jeffrey, P.D, Pavletich, N.P. | Deposit date: | 1996-07-03 | Release date: | 1997-07-29 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature, 382, 1996
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1LGP
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![BU of 1lgp by Molmil](/molmil-images/mine/1lgp) | Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein complexed with tungstate | Descriptor: | TUNGSTATE(VI)ION, cell cycle checkpoint protein CHFR | Authors: | Stavridi, E.S, Huyen, Y, Loreto, I.R, Scolnick, D.M, Halazonetis, T.D, Pavletich, N.P, Jeffrey, P.D. | Deposit date: | 2002-04-16 | Release date: | 2002-05-08 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate. Structure, 10, 2002
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1LDD
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![BU of 1ldd by Molmil](/molmil-images/mine/1ldd) | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex | Descriptor: | Anaphase Promoting Complex | Authors: | Zheng, N, Schulman, B.A, Song, L, Miller, J.J, Jeffrey, P.D, Wang, P, Chu, C, Koepp, D.M, Elledge, S.J, Pagano, M, Conaway, R.C, Conaway, J.W, Harper, J.W, Pavletich, N.P. | Deposit date: | 2002-04-08 | Release date: | 2002-05-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature, 416, 2002
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1LDK
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![BU of 1ldk by Molmil](/molmil-images/mine/1ldk) | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex | Descriptor: | CULLIN HOMOLOG, CYCLIN A/CDK2-ASSOCIATED PROTEIN P19, SKP2-like protein type gamma, ... | Authors: | Zheng, N, Schulman, B.A, Song, L, Miller, J.J, Jeffrey, P.D, Wang, P, Chu, C, Koepp, D.M, Elledge, S.J, Pagano, M, Conaway, R.C, Conaway, J.W, Harper, J.W, Pavletich, N.P. | Deposit date: | 2002-04-08 | Release date: | 2002-05-08 | Last modified: | 2019-11-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature, 416, 2002
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1LGQ
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![BU of 1lgq by Molmil](/molmil-images/mine/1lgq) | Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein | Descriptor: | cell cycle checkpoint protein CHFR | Authors: | Stavridi, E.S, Huyen, Y, Loreto, I.R, Scolnick, D.M, Halazonetis, T.D, Pavletich, N.P, Jeffrey, P.D. | Deposit date: | 2002-04-16 | Release date: | 2002-05-08 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate. Structure, 10, 2002
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1L0B
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![BU of 1l0b by Molmil](/molmil-images/mine/1l0b) | Crystal Structure of rat Brca1 tandem-BRCT region | Descriptor: | BRCA1 | Authors: | Joo, W.S, Jeffrey, P.D, Cantor, S.B, Finnin, M.S, Livingston, D.M, Pavletich, N.P. | Deposit date: | 2002-02-08 | Release date: | 2002-03-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. Genes Dev., 16, 2002
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1LDJ
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![BU of 1ldj by Molmil](/molmil-images/mine/1ldj) | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex | Descriptor: | Cullin homolog 1, ZINC ION, ring-box protein 1 | Authors: | Zheng, N, Schulman, B.A, Song, L, Miller, J.J, Jeffrey, P.D, Wang, P, Chu, C, Koepp, D.M, Elledge, S.J, Pagano, M, Conaway, R.C, Conaway, J.W, Harper, J.W, Pavletich, N.P. | Deposit date: | 2002-04-08 | Release date: | 2002-05-08 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature, 416, 2002
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1KZY
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![BU of 1kzy by Molmil](/molmil-images/mine/1kzy) | Crystal Structure of the 53bp1 BRCT Region Complexed to Tumor Suppressor P53 | Descriptor: | CELLULAR TUMOR ANTIGEN P53, TUMOR SUPPRESSOR P53-BINDING PROTEIN 1, ZINC ION | Authors: | Joo, W.S, Jeffrey, P.D, Cantor, S.B, Finnin, M.S, Livingston, D.M, Pavletich, N.P. | Deposit date: | 2002-02-08 | Release date: | 2002-03-20 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. Genes Dev., 16, 2002
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1IIN
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![BU of 1iin by Molmil](/molmil-images/mine/1iin) | thymidylyltransferase complexed with UDP-glucose | Descriptor: | URIDINE-5'-DIPHOSPHATE-GLUCOSE, glucose-1-phosphate thymidylyltransferase | Authors: | Barton, W.A, Lesniak, J, Biggins, J.B, Jeffrey, P.D, Jiang, J, Rajashankar, K.R, Thorson, J.S, Nikolov, D.B. | Deposit date: | 2001-04-23 | Release date: | 2001-05-09 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization. Nat.Struct.Biol., 8, 2001
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1IYJ
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![BU of 1iyj by Molmil](/molmil-images/mine/1iyj) | STRUCTURE OF A BRCA2-DSS1 COMPLEX | Descriptor: | Deleted in split hand/split foot protein 1, breast cancer susceptibility | Authors: | Pavletich, N.P, Jeffrey, P.D, Yang, H.J. | Deposit date: | 2002-08-28 | Release date: | 2002-10-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science, 297, 2002
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1MIU
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![BU of 1miu by Molmil](/molmil-images/mine/1miu) | Structure of a BRCA2-DSS1 complex | Descriptor: | Breast Cancer type 2 susceptibility protein, Deleted in split hand/split foot protein 1, MERCURY (II) ION | Authors: | Yang, H, Jeffrey, P.D, Miller, J, Kinnucan, E, Sun, Y, Thoma, N.H, Zheng, N, Chen, P.L, Lee, W.H, Pavletich, N.P. | Deposit date: | 2002-08-23 | Release date: | 2002-09-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA
structure Science, 297, 2002
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3IA3
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![BU of 3ia3 by Molmil](/molmil-images/mine/3ia3) | |
3KKI
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![BU of 3kki by Molmil](/molmil-images/mine/3kki) | PLP-Dependent Acyl-CoA transferase CqsA | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CAI-1 autoinducer synthase, MAGNESIUM ION, ... | Authors: | Kelly, R.C, Jeffrey, P.D, Hughson, F.M. | Deposit date: | 2009-11-05 | Release date: | 2009-11-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nat.Chem.Biol., 5, 2009
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3K8P
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![BU of 3k8p by Molmil](/molmil-images/mine/3k8p) | |
3HQT
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![BU of 3hqt by Molmil](/molmil-images/mine/3hqt) | PLP-Dependent Acyl-CoA Transferase CqsA | Descriptor: | CAI-1 autoinducer synthase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Kelly, R.C, Jeffrey, P.D, Hughson, F.M. | Deposit date: | 2009-06-08 | Release date: | 2009-10-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nat.Chem.Biol., 5, 2009
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