4UN3
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![BU of 4un3 by Molmil](/molmil-images/mine/4un3) | Crystal structure of Cas9 bound to PAM-containing DNA target | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | Authors: | Anders, C, Niewoehner, O, Duerst, A, Jinek, M. | Deposit date: | 2014-05-25 | Release date: | 2014-07-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.593 Å) | Cite: | Structural Basis of Pam-Dependent Target DNA Recognition by the Cas9 Endonuclease Nature, 513, 2014
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4UN5
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![BU of 4un5 by Molmil](/molmil-images/mine/4un5) | Crystal structure of Cas9 bound to PAM-containing DNA target containing mismatches at positions 1-3 | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | Authors: | Anders, C, Niewoehner, O, Duerst, A, Jinek, M. | Deposit date: | 2014-05-25 | Release date: | 2014-07-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Basis of Pam-Dependent Target DNA Recognition by the Cas9 Endonuclease Nature, 513, 2014
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4UN4
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![BU of 4un4 by Molmil](/molmil-images/mine/4un4) | Crystal structure of Cas9 bound to PAM-containing DNA target with mismatches at positions 1-2 | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | Authors: | Anders, C, Niewoehner, O, Duerst, A, Jinek, M. | Deposit date: | 2014-05-25 | Release date: | 2014-07-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.371 Å) | Cite: | Structural Basis of Pam-Dependent Target DNA Recognition by the Cas9 Endonuclease Nature, 513, 2014
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3ICQ
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![BU of 3icq by Molmil](/molmil-images/mine/3icq) | Karyopherin nuclear state | Descriptor: | Exportin-T, GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Cook, A.G, Fukuhara, N, Jinek, M, Conti, E. | Deposit date: | 2009-07-18 | Release date: | 2009-08-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structures of the tRNA export factor in the nuclear and cytosolic states Nature, 461, 2009
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3IBV
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![BU of 3ibv by Molmil](/molmil-images/mine/3ibv) | Karyopherin cytosolic state | Descriptor: | CALCIUM ION, Exportin-T | Authors: | Cook, A.G, Fukuhara, N, Jinek, M, Conti, E. | Deposit date: | 2009-07-17 | Release date: | 2009-08-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structures of the tRNA export factor in the nuclear and cytosolic states Nature, 461, 2009
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5L6D
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![BU of 5l6d by Molmil](/molmil-images/mine/5l6d) | |
5L6E
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![BU of 5l6e by Molmil](/molmil-images/mine/5l6e) | |
6RW0
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![BU of 6rw0 by Molmil](/molmil-images/mine/6rw0) | Crystal structure of ANGEL2, a 2',3'-cyclic phosphatase | Descriptor: | GLYCEROL, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Kroupova, A, Jinek, M. | Deposit date: | 2019-06-03 | Release date: | 2020-05-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity. Science, 369, 2020
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6RVZ
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![BU of 6rvz by Molmil](/molmil-images/mine/6rvz) | Crystal structure of ANGEL2, a 2',3'-cyclic phosphatase, in complex with adenosine-2',3'-vanadate | Descriptor: | ADENOSINE, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Kroupova, A, Jinek, M. | Deposit date: | 2019-06-03 | Release date: | 2020-05-20 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity. Science, 369, 2020
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5FQ5
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![BU of 5fq5 by Molmil](/molmil-images/mine/5fq5) | Crystal structure of Cas9-sgRNA-DNA complex solved by native SAD phasing | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | Authors: | Olieric, V, Weinert, T, Finke, A, Anders, C, Jinek, M, Wang, M. | Deposit date: | 2015-12-07 | Release date: | 2016-03-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.136 Å) | Cite: | Data-Collection Strategy for Challenging Native Sad Phasing. Acta Crystallogr.,Sect.D, 72, 2016
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6F9N
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![BU of 6f9n by Molmil](/molmil-images/mine/6f9n) | CRYSTAL STRUCTURE OF THE HUMAN CPSF160-WDR33 COMPLEX | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33 | Authors: | Clerici, M, Jinek, M. | Deposit date: | 2017-12-14 | Release date: | 2018-01-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex. Elife, 6, 2017
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6FUW
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![BU of 6fuw by Molmil](/molmil-images/mine/6fuw) | Cryo-EM structure of the human CPSF160-WDR33-CPSF30 complex bound to the PAS AAUAAA motif at 3.1 Angstrom resolution | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, RNA (5'-R(P*AP*AP*UP*AP*AP*AP*GP*G)-3'), ... | Authors: | Clerici, M, Faini, M, Jinek, M. | Deposit date: | 2018-02-28 | Release date: | 2018-03-21 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex. Nat. Struct. Mol. Biol., 25, 2018
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5NG6
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![BU of 5ng6 by Molmil](/molmil-images/mine/5ng6) | |
5NFV
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![BU of 5nfv by Molmil](/molmil-images/mine/5nfv) | Crystal structure of catalytically inactive FnCas12 mutant bound to an R-loop structure containing a pre-crRNA mimic and full-length DNA target | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CRISPR-associated endonuclease Cpf1, DNA non-target strand, ... | Authors: | Swarts, D.C, van der Oost, J, Jinek, M. | Deposit date: | 2017-03-16 | Release date: | 2017-06-14 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a. Mol. Cell, 66, 2017
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2XLI
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![BU of 2xli by Molmil](/molmil-images/mine/2xli) | Crystal structure of the Csy4-crRNA complex, monoclinic form | Descriptor: | 5'-R(*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP*CP*A*DG*C)-3', CSY4 ENDORIBONUCLEASE | Authors: | Haurwitz, R.E, Jinek, M, Wiedenheft, B, Zhou, K, Doudna, J.A. | Deposit date: | 2010-07-20 | Release date: | 2010-09-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Sequence- and Structure-Specific RNA Processing by a Crispr Endonuclease. Science, 329, 2010
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2Y9H
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![BU of 2y9h by Molmil](/molmil-images/mine/2y9h) | |
2Y8W
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![BU of 2y8w by Molmil](/molmil-images/mine/2y8w) | |
2Y8Y
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![BU of 2y8y by Molmil](/molmil-images/mine/2y8y) | |
7Z4E
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![BU of 7z4e by Molmil](/molmil-images/mine/7z4e) | SpCas9 bound to 8-nucleotide complementary DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 8 nucleotide complementary DNA substrate, Target strand of 8 nucleotide complementary DNA substrate, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-03-03 | Release date: | 2022-08-31 | Last modified: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (4.14 Å) | Cite: | R-loop formation and conformational activation mechanisms of Cas9. Nature, 609, 2022
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7Z4I
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![BU of 7z4i by Molmil](/molmil-images/mine/7z4i) | SpCas9 bound to 16-nucleotide complementary DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 16-nucleotide complementary DNA substrate, POTASSIUM ION, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-03-03 | Release date: | 2022-08-31 | Last modified: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | R-loop formation and conformational activation mechanisms of Cas9. Nature, 609, 2022
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7Z4C
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![BU of 7z4c by Molmil](/molmil-images/mine/7z4c) | SpCas9 bound to 6 nucleotide complementary DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 6 nucleotide complementary DNA substrate, Target strand of 6 nucleotide complementary DNA substrate, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-03-03 | Release date: | 2022-08-31 | Last modified: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (3.87 Å) | Cite: | R-loop formation and conformational activation mechanisms of Cas9. Nature, 609, 2022
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7Z4G
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![BU of 7z4g by Molmil](/molmil-images/mine/7z4g) | SpCas9 bound to 12-nucleotide complementary DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 12-nucleotide complementary DNA substrate, Target strand of 12-nucleotide complementary DNA substrate, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-03-03 | Release date: | 2022-08-31 | Last modified: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (3.64 Å) | Cite: | R-loop formation and conformational activation mechanisms of Cas9. Nature, 609, 2022
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7Z4K
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![BU of 7z4k by Molmil](/molmil-images/mine/7z4k) | SpCas9 bound to 10-nucleotide complementary DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 10-nucleotide complementary DNA substrate, Target strand of 10-nucleotide complementary DNA substrate, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-03-04 | Release date: | 2022-08-31 | Last modified: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (3.81 Å) | Cite: | R-loop formation and conformational activation mechanisms of Cas9. Nature, 609, 2022
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7Z4H
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![BU of 7z4h by Molmil](/molmil-images/mine/7z4h) | SpCas9 bound to 14-nucleotide complementary DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 14-nucleotide complementary DNA substrate, Target strand of 14-nucleotide complementary DNA substrate, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-03-03 | Release date: | 2022-08-31 | Last modified: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | R-loop formation and conformational activation mechanisms of Cas9. Nature, 609, 2022
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7Z4J
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![BU of 7z4j by Molmil](/molmil-images/mine/7z4j) | |