1SC3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1sc3 by Molmil](/molmil-images/mine/1sc3) | Crystal structure of the human caspase-1 C285A mutant in complex with malonate | Descriptor: | Interleukin-1 beta convertase, MALONATE ION | Authors: | Romanowski, M.J, Scheer, J.M, O'Brien, T, McDowell, R.S. | Deposit date: | 2004-02-11 | Release date: | 2004-08-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding. Structure, 12, 2004
|
|
1SC1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1sc1 by Molmil](/molmil-images/mine/1sc1) | Crystal structure of an active-site ligand-free form of the human caspase-1 C285A mutant | Descriptor: | CHLORIDE ION, Interleukin-1 beta convertase | Authors: | Romanowski, M.J, Scheer, J.M, O'Brien, T, McDowell, R.S. | Deposit date: | 2004-02-11 | Release date: | 2004-08-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding. Structure, 12, 2004
|
|
1SL3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1sl3 by Molmil](/molmil-images/mine/1sl3) | crystal structue of Thrombin in complex with a potent P1 heterocycle-Aryl based inhibitor | Descriptor: | (2-[6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDOPYRIDIN-2-YL)ETHYL]AMINO}-2-OXOPYRAZIN-1(2H)-YL]-N-[5-CHLORO-2-(1H-TETRAZOL-1-YL)BENZYL]ACETAMIDE, Hirudin, thrombin | Authors: | Young, M.B, Barrow, J.C, Glass, K.L, Lundell, G.F, Newton, C.L, Pellicore, J.M, Rittle, K.E, Selnick, H.G, Stauffer, K.J, Vacca, J.P, Williams, P.D, Bohn, D, Clayton, F.C, Cook, J.J, Krueger, J.A, Kuo, L.C, Lewis, S.D, Lucas, B.J, McMasters, D.R, Miller-Stein, C, Pietrak, B.L. | Deposit date: | 2004-03-05 | Release date: | 2004-08-03 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitors J.Med.Chem., 47, 2004
|
|
1DL5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1dl5 by Molmil](/molmil-images/mine/1dl5) | PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE | Descriptor: | CADMIUM ION, CHLORIDE ION, PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE, ... | Authors: | Skinner, M.M, Puvathingal, J.M, Walter, R.L, Friedman, A.M. | Deposit date: | 1999-12-08 | Release date: | 2000-12-08 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of protein isoaspartyl methyltransferase: a catalyst for protein repair. Structure Fold.Des., 8, 2000
|
|
1SII
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1sii by Molmil](/molmil-images/mine/1sii) | AGAO in covalent complex with the inhibitor NOBA ("4-(2-naphthyloxy)-2-butyn-1-amine") | Descriptor: | COPPER (II) ION, GLYCEROL, Phenylethylamine oxidase, ... | Authors: | Guss, J.M, Langley, D.B, Duff, A.P. | Deposit date: | 2004-02-29 | Release date: | 2004-09-07 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Differential Inhibition of Six Copper Amine Oxidases by a Family of 4-(Aryloxy)-2-butynamines: Evidence for a New Mode of Inactivation. Biochemistry, 43, 2004
|
|
1SQR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1sqr by Molmil](/molmil-images/mine/1sqr) | Solution Structure of the 50S Ribosomal Protein L35AE from Pyrococcus furiosus. Northeast Structural Genomics Consortium Target PfR48. | Descriptor: | 50S ribosomal protein L35Ae | Authors: | Snyder, D.A, Aramini, J.M, Huang, Y.J, Xiao, R, Cort, J.R, Shastry, R, Ma, L.C, Liu, J, Rost, B, Acton, T.B, Kennedy, M.A, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2004-03-19 | Release date: | 2004-11-16 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution Structure of the 50S Ribosomal Protein L35AE from Pyrococcus furiosus: Northeast Structural Genomics Consortium Target PfR48 To be Published
|
|
2JBX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2jbx by Molmil](/molmil-images/mine/2jbx) | Crystal Structure of the myxoma virus anti-apoptotic protein M11L | Descriptor: | M11L PROTEIN | Authors: | Kvansakul, M, Van Delft, M.F, Lee, E.F, Gulbis, J.M, Fairlie, W.D, Huang, D.C.S, Colman, P.M. | Deposit date: | 2006-12-14 | Release date: | 2007-03-27 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak. Mol.Cell, 25, 2007
|
|
1S81
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1s81 by Molmil](/molmil-images/mine/1s81) | PORCINE TRYPSIN WITH NO INHIBITOR BOUND | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, SODIUM ION, ... | Authors: | Transue, T.R, Krahn, J.M, Gabel, S.A, DeRose, E.F, London, R.E. | Deposit date: | 2004-01-30 | Release date: | 2004-03-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | X-ray and NMR characterization of covalent complexes of trypsin, borate, and alcohols. Biochemistry, 43, 2004
|
|
2K42
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2k42 by Molmil](/molmil-images/mine/2k42) | Solution Structure of the GTPase Binding Domain of WASP in Complex with EspFU, an EHEC Effector | Descriptor: | ESPFU, Wiskott-Aldrich syndrome protein | Authors: | Cheng, H.-C, Skehan, B.M, Campellone, K.G, Leong, J.M, Rosen, M.K. | Deposit date: | 2008-05-27 | Release date: | 2008-07-22 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U). Nature, 454, 2008
|
|
1SJ0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1sj0 by Molmil](/molmil-images/mine/1sj0) | Human Estrogen Receptor Alpha Ligand-binding Domain in Complex with the Antagonist Ligand 4-D | Descriptor: | (2S,3R)-2-(4-(2-(PIPERIDIN-1-YL)ETHOXY)PHENYL)-2,3-DIHYDRO-3-(4-HYDROXYPHENYL)BENZO[B][1,4]OXATHIIN-6-OL, Estrogen receptor | Authors: | Kim, S, Wu, J.Y, Birzin, E.T, Chan, W, Pai, L.Y, Yang, Y.T, Mosley, R.T, Fitzgerald, P.M, Sharma, N, DiNinno, F, Rohrer, S.P, Schaeffer, J.M, Hammond, M.L. | Deposit date: | 2004-03-02 | Release date: | 2004-04-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Estrogen Receptor Ligands. II. Discovery of Benzoxathiins as Potent, Selective Estrogen Receptor alpha Modulators. J.Med.Chem., 47, 2004
|
|
1SFP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1sfp by Molmil](/molmil-images/mine/1sfp) | CRYSTAL STRUCTURE OF ACIDIC SEMINAL FLUID PROTEIN (ASFP) AT 1.9 A RESOLUTION: A BOVINE POLYPEPTIDE FROM THE SPERMADHESIN FAMILY | Descriptor: | ASFP | Authors: | Romao, M.J, Kolln, I, Dias, J.M, Carvalho, A.L, Romero, A, Varela, P.F, Sanz, L, Topfer-Petersen, E, Calvete, J.J. | Deposit date: | 1997-06-24 | Release date: | 1998-06-24 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The crystal structures of two spermadhesins reveal the CUB domain fold. Nat.Struct.Biol., 4, 1997
|
|
2JED
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2jed by Molmil](/molmil-images/mine/2jed) | The crystal structure of the kinase domain of the protein kinase C theta in complex with NVP-XAA228 at 2.32A resolution. | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3-(8-DIMETHYLAMINOMETHYL-6,7,8,9-TETRAHYDRO-PYRIDO[1,2-A]INDOL-10-YL)-4-(1-METHYL-1H-INDOL-3-YL)-PYRROLE-2,5-DIONE, PROTEIN KINASE C THETA | Authors: | Stark, W, Bitsch, F, Berner, A, Buelens, F, Graff, P, Depersin, H, Geiser, M, Knecht, R, Rahuel, J, Rummel, G, Schlaeppi, J.M, Schmitz, R, Strauss, A, Wagner, J. | Deposit date: | 2007-01-16 | Release date: | 2008-02-05 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | The Crystal Structure of the Kinase Domain of the Protein Kinase C Theta in Complex with Nvp-Xaa228 To be Published
|
|
1SIH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1sih by Molmil](/molmil-images/mine/1sih) | AGAO in covalent complex with the inhibitor MOBA ("4-(4-methylphenoxy)-2-butyn-1-amine") | Descriptor: | COPPER (II) ION, GLYCEROL, Phenylethylamine oxidase, ... | Authors: | Guss, J.M, Langley, D.B, Duff, A.P. | Deposit date: | 2004-02-29 | Release date: | 2004-09-07 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Differential Inhibition of Six Copper Amine Oxidases by a Family of 4-(Aryloxy)-2-butynamines: Evidence for a New Mode of Inactivation. Biochemistry, 43, 2004
|
|
1UTZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1utz by Molmil](/molmil-images/mine/1utz) | Crystal Structure of MMP-12 complexed to (2R)-3-({[4-[(pyridin-4-yl)phenyl]-thien-2-yl}carboxamido)(phenyl)propanoic acid | Descriptor: | (2R)-3-({[4-[(PYRIDIN-4-YL)PHENYL]-THIEN-2-YL}CARBOXAMIDO)(PHENYL)PROPANOIC ACID, ACETOHYDROXAMIC ACID, CALCIUM ION, ... | Authors: | Morales, R, Perrier, S, Florent, J.M, Beltra, J, Dufour, S, De Mendez, I, Manceau, P, Tertre, A, Moreau, F, Compere, D, Dublanchet, A.C, O'Gara, M. | Deposit date: | 2003-12-12 | Release date: | 2004-12-15 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structures of Novel Non-Peptidic, Non-Zinc Chelating Inhibitors Bound to Mmp-12 J.Mol.Biol., 341, 2004
|
|
1UVN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1uvn by Molmil](/molmil-images/mine/1uvn) | The structural basis for RNA specificity and Ca2 inhibition of an RNA-dependent RNA polymerase phi6p2 ca2+ inhibition complex | Descriptor: | 5'-R(*UP*UP*UP*UP*CP*CP)-3', CALCIUM ION, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Salgado, P.S, Makeyev, E.V, Butcher, S, Bamford, D, Stuart, D.I, Grimes, J.M. | Deposit date: | 2004-01-21 | Release date: | 2004-02-26 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The structural basis for RNA specificity and Ca2+ inhibition of an RNA-dependent RNA polymerase. Structure, 12, 2004
|
|
1UTT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1utt by Molmil](/molmil-images/mine/1utt) | Crystal Structure of MMP-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl-4-(4-ethoxy[1,1-biphenyl]-4-yl)-4-oxobutanoic acid | Descriptor: | 2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL) ETHYL-4-(4'-ETHOXY [1,1'-BIPHENYL]-4-YL)-4-OXOBUTANOIC ACID, ACETOHYDROXAMIC ACID, CALCIUM ION, ... | Authors: | Morales, R, Perrier, S, Florent, J.M, Beltra, J, Dufour, S, De Mendez, I, Manceau, P, Tertre, A, Moreau, F, Compere, D, Dublanchet, A.C, O'Gara, M. | Deposit date: | 2003-12-10 | Release date: | 2004-12-15 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12. J. Mol. Biol., 341, 2004
|
|
1UOS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1uos by Molmil](/molmil-images/mine/1uos) | The Crystal Structure of the Snake Venom Toxin Convulxin | Descriptor: | CONVULXIN ALPHA, CONVULXIN BETA | Authors: | Batuwangala, T, Leduc, M, Gibbins, J.M, Bon, C, Jones, E.Y. | Deposit date: | 2003-09-22 | Release date: | 2003-10-14 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of the Snake-Venom Toxin Convulxin Acta Crystallogr.,Sect.D, 60, 2004
|
|
2LSS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2lss by Molmil](/molmil-images/mine/2lss) | Solution structure of the R. rickettsii cold shock-like protein | Descriptor: | Cold shock-like protein | Authors: | Veldkamp, C.T, Peterson, F.C, Gerarden, K.P, Fuchs, A.M, Koch, J.M, Mueller, M.M. | Deposit date: | 2012-05-04 | Release date: | 2012-05-16 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of the cold-shock-like protein from Rickettsia rickettsii. Acta Crystallogr.,Sect.F, 68, 2012
|
|
1BB8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1bb8 by Molmil](/molmil-images/mine/1bb8) | |
2L4Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2l4z by Molmil](/molmil-images/mine/2l4z) | NMR structure of fusion of CtIP (641-685) to LMO4-LIM1 (18-82) | Descriptor: | DNA endonuclease RBBP8,LIM domain transcription factor LMO4, ZINC ION | Authors: | Liew, C, Stokes, P.H, Kwan, A.H, Matthews, J.M. | Deposit date: | 2010-10-22 | Release date: | 2011-10-26 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structural Basis of the Interaction of the Breast Cancer Oncogene LMO4 with the Tumour Suppressor CtIP/RBBP8. J.Mol.Biol., 425, 2013
|
|
1BIK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1bik by Molmil](/molmil-images/mine/1bik) | X-RAY STRUCTURE OF BIKUNIN FROM THE HUMAN INTER-ALPHA-INHIBITOR COMPLEX | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BIKUNIN, SULFATE ION | Authors: | Xu, Y, Carr, P.D, Guss, J.M, Ollis, D.L. | Deposit date: | 1997-11-26 | Release date: | 1999-03-16 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The crystal structure of bikunin from the inter-alpha-inhibitor complex: a serine protease inhibitor with two Kunitz domains. J.Mol.Biol., 276, 1998
|
|
2L3O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2l3o by Molmil](/molmil-images/mine/2l3o) | Solution structure of murine interleukin 3 | Descriptor: | Interleukin 3 | Authors: | Yao, S, Young, I.G, Norton, R.S, Murphy, J.M. | Deposit date: | 2010-09-20 | Release date: | 2011-08-10 | Method: | SOLUTION NMR | Cite: | Murine interleukin-3: structure, dynamics, and conformational heterogeneity in solution. Biochemistry, 50, 2011
|
|
2L57
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2l57 by Molmil](/molmil-images/mine/2l57) | Solution Structure of an Uncharacterized Thioredoin-like Protein from Clostridium perfringens | Descriptor: | Uncharacterized protein | Authors: | Harris, R, Foti, R, Seidel, R.D, Bonanno, J.B, Freeman, J, Bain, K.T, Sauder, J.M, Burley, S.K, Girvin, M.E, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC), New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2010-10-26 | Release date: | 2010-11-17 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution Structure of an Uncharacterized Thioredoin-like Protein from Clostridium perfringens To be Published
|
|
1UVL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1uvl by Molmil](/molmil-images/mine/1uvl) | The structural basis for RNA specificity and Ca2 inhibition of an RNA-dependent RNA polymerase phi6p2 with 5nt RNA. Conformation B | Descriptor: | 5'-R(*UP*UP*UP*CP*CP)-3', MANGANESE (II) ION, RNA-directed RNA polymerase | Authors: | Salgado, P.S, Makeyev, E.V, Butcher, S, Bamford, D, Stuart, D.I, Grimes, J.M. | Deposit date: | 2004-01-21 | Release date: | 2004-02-26 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structural basis for RNA specificity and Ca2+ inhibition of an RNA-dependent RNA polymerase. Structure, 12, 2004
|
|
2LNH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2lnh by Molmil](/molmil-images/mine/2lnh) | Enterohaemorrhagic E. coli (EHEC) exploits a tryptophan switch to hijack host F-actin assembly | Descriptor: | Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1, Neural Wiskott-Aldrich syndrome protein, Secreted effector protein EspF(U) | Authors: | Aitio, O, Hellman, M, Skehan, B, Kesti, T, Leong, J.M, Saksela, K, Permi, P. | Deposit date: | 2011-12-28 | Release date: | 2012-08-29 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly. Structure, 20, 2012
|
|