2K42

Solution Structure of the GTPase Binding Domain of WASP in Complex with EspFU, an EHEC Effector

Summary for 2K42

DescriptorWiskott-Aldrich syndrome protein, ESPFU (2 entities in total)
Functional Keywordswasp, espfu, gbd, autoinhibition, cytoplasm, cytoskeleton, disease mutation, phosphoprotein, signaling protein
Biological sourceHomo sapiens (human)
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Cellular locationCytoplasm, cytoskeleton P42768
Total number of polymer chains2
Total molecular weight12199.59
Authors
Cheng, H.-C.,Skehan, B.M.,Campellone, K.G.,Leong, J.M.,Rosen, M.K. (deposition date: 2008-05-27, release date: 2008-07-22, Last modification date: 2011-07-13)
Primary citation
Cheng, H.C.,Skehan, B.M.,Campellone, K.G.,Leong, J.M.,Rosen, M.K.
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U).
Nature, 454:1009-1013, 2008
PubMed: 18650809 (PDB entries with the same primary citation)
DOI: 10.1038/nature07160
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers182.0%4.7%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
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PDB entries from 2020-08-05