Solution Structure of the GTPase Binding Domain of WASP in Complex with EspFU, an EHEC Effector

Summary for 2K42

DescriptorWiskott-Aldrich syndrome protein, ESPFU (2 entities in total)
Functional Keywordswasp, espfu, gbd, autoinhibition, cytoplasm, cytoskeleton, disease mutation, phosphoprotein, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton P42768
Total number of polymer chains2
Total molecular weight12199.59
Cheng, H.-C.,Skehan, B.M.,Campellone, K.G.,Leong, J.M.,Rosen, M.K. (deposition date: 2008-05-27, release date: 2008-07-22, Last modification date: 2011-07-13)
Primary citation
Cheng, H.C.,Skehan, B.M.,Campellone, K.G.,Leong, J.M.,Rosen, M.K.
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U).
Nature, 454:1009-1013, 2008
PubMed: 18650809 (PDB entries with the same primary citation)
DOI: 10.1038/nature07160
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers182.0%4.7%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation reportDownload
PDB entries from 2020-08-05