1UDU
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![BU of 1udu by Molmil](/molmil-images/mine/1udu) | Crystal structure of Human Phosphodiesterase 5 complexed with tadalafil(Cialis) | Descriptor: | 6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1',2':1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE, MAGNESIUM ION, ZINC ION, ... | Authors: | Sung, B.-J, Lee, J.I, Heo, Y.-S, Kim, J.H, Moon, J, Yoon, J.M, Hyun, Y.-L, Kim, E, Eum, S.J, Lee, T.G, Cho, J.M, Park, S.-Y, Lee, J.-O, Jeon, Y.H, Hwang, K.Y, Ro, S. | Deposit date: | 2003-05-06 | Release date: | 2004-05-11 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules Nature, 425, 2003
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7Z4T
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![BU of 7z4t by Molmil](/molmil-images/mine/7z4t) | AAL160 FAB IN COMPLEX WITH HUMAN INTERLEUKIN-1 BETA | Descriptor: | AAL160 Fab heavy-chain, AAL160 light-chain, Interleukin-1 beta | Authors: | Rondeau, J.M, Lehmann, S. | Deposit date: | 2022-03-04 | Release date: | 2023-02-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | "Redirecting an anti-IL-1 beta antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A". Commun Biol, 6, 2023
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7Z3W
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![BU of 7z3w by Molmil](/molmil-images/mine/7z3w) | Crystal structure of the AAL160 Fab | Descriptor: | 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, AAL160 Fab heavy-chain, AAL160 Fab light-chain | Authors: | Rondeau, J.M, Lehmann, S. | Deposit date: | 2022-03-02 | Release date: | 2023-02-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | "Redirecting an anti-IL-1 beta antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A". Commun Biol, 6, 2023
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7Z2M
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7Z5L
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7Z5Q
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1UHO
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![BU of 1uho by Molmil](/molmil-images/mine/1uho) | Crystal structure of Human Phosphodiesterase 5 complexed with Vardenafil(Levitra) | Descriptor: | 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE, MAGNESIUM ION, ZINC ION, ... | Authors: | Sung, B.-J, Lee, J.I, Heo, Y.-S, Kim, J.H, Moon, J, Yoon, J.M, Hyun, Y.-L, Kim, E, Eum, S.J, Lee, T.G, Cho, J.M, Park, S.-Y, Lee, J.-O, Jeon, Y.H, Hwang, K.Y, Ro, S. | Deposit date: | 2003-07-09 | Release date: | 2004-07-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules Nature, 425, 2003
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7YR7
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![BU of 7yr7 by Molmil](/molmil-images/mine/7yr7) | Cryo-EM structure of Pseudomonas aeruginosa RsmZ RNA in complex with three RsmA protein dimers | Descriptor: | RsmZ RNA (118-MER), Translational regulator CsrA | Authors: | Jia, X, Pan, Z, Yuan, Y, Luo, B, Luo, Y, Mukherjee, S, Jia, G, Liu, L, Ling, X, Yang, X, Wu, Y, Liu, T, Miao, Z, Wei, X, Bujnicki, J.M, Zhao, K, Su, Z. | Deposit date: | 2022-08-09 | Release date: | 2023-05-17 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence. Cell Res., 33, 2023
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7YR6
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![BU of 7yr6 by Molmil](/molmil-images/mine/7yr6) | Cryo-EM structure of Pseudomonas aeruginosa RsmZ RNA in complex with two RsmA protein dimers | Descriptor: | RsmZ RNA, Translational regulator CsrA | Authors: | Jia, X, Pan, Z, Yuan, Y, Luo, B, Luo, Y, Mukherjee, S, Jia, G, Ling, X, Yang, X, Wu, Y, Liu, T, Wei, X, Bujnick, J.M, Zhao, K, Su, Z. | Deposit date: | 2022-08-09 | Release date: | 2023-05-17 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence. Cell Res., 33, 2023
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4MWI
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![BU of 4mwi by Molmil](/molmil-images/mine/4mwi) | Crystal structure of the human MLKL pseudokinase domain | Descriptor: | (2S)-1-[3-{[(2R)-2-hydroxypropyl]oxy}-2,2-bis({[(2R)-2-hydroxypropyl]oxy}methyl)propoxy]propan-2-ol, GLYCEROL, Mixed lineage kinase domain-like protein | Authors: | Czabotar, P.E, Murphy, J.M. | Deposit date: | 2013-09-25 | Release date: | 2013-12-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL. Biochem.J., 457, 2014
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4MX5
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![BU of 4mx5 by Molmil](/molmil-images/mine/4mx5) | Structure of ricin A chain bound with benzyl-(2-(2-amino-4-oxo-3,4-dihydropteridine-7-carboxamido)ethyl)carbamate | Descriptor: | Ricin A chain, benzyl (2-{[(2-amino-4-oxo-3,4-dihydropteridin-7-yl)carbonyl]amino}ethyl)carbamate | Authors: | Jasheway, K.R, Robertus, J.D, Wiget, P.A, Manzano, L.A, Pruet, J.M, Gao, G, Saito, R, Monzingo, A.F, Anslyn, E.V. | Deposit date: | 2013-09-25 | Release date: | 2014-01-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Sulfur incorporation generally improves Ricin inhibition in pterin-appended glycine-phenylalanine dipeptide mimics. Bioorg.Med.Chem.Lett., 23, 2013
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4MN4
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![BU of 4mn4 by Molmil](/molmil-images/mine/4mn4) | Structural Basis for the MukB-topoisomerase IV Interaction | Descriptor: | Chromosome partition protein MukB, DNA topoisomerase 4 subunit A | Authors: | Vos, S.M, Stewart, N.K, Oakley, M.G, Berger, J.M. | Deposit date: | 2013-09-09 | Release date: | 2013-10-23 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for the MukB-topoisomerase IV interaction and its functional implications in vivo. Embo J., 32, 2013
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4N48
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![BU of 4n48 by Molmil](/molmil-images/mine/4n48) | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Protein in complex with capped RNA fragment | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, S-ADENOSYLMETHIONINE, ... | Authors: | Smietanski, M, Werener, M, Purta, E, Kaminska, K.H, Stepinski, J, Darzynkiewicz, E, Nowotny, M, Bujnicki, J.M. | Deposit date: | 2013-10-08 | Release date: | 2014-01-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.704 Å) | Cite: | Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation. Nat Commun, 5, 2014
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4N6A
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![BU of 4n6a by Molmil](/molmil-images/mine/4n6a) | Soybean Serine Acetyltransferase Apoenzyme | Descriptor: | PHOSPHATE ION, Serine Acetyltransferase Apoenzyme | Authors: | Yi, H, Dey, S, Kumaran, S, Krishnan, H.B, Jez, J.M. | Deposit date: | 2013-10-11 | Release date: | 2013-11-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure of soybean serine acetyltransferase and formation of the cysteine regulatory complex as a molecular chaperone. J.Biol.Chem., 288, 2013
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4N6B
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![BU of 4n6b by Molmil](/molmil-images/mine/4n6b) | Soybean Serine Acetyltransferase Complexed with CoA | Descriptor: | COENZYME A, Serine Acetyltransferase Apoenzyme | Authors: | Yi, H, Dey, S, Kumaran, S, Krishnan, H.B, Jez, J.M. | Deposit date: | 2013-10-11 | Release date: | 2013-11-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.005 Å) | Cite: | Structure of soybean serine acetyltransferase and formation of the cysteine regulatory complex as a molecular chaperone. J.Biol.Chem., 288, 2013
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4N7M
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4N6G
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4N6W
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![BU of 4n6w by Molmil](/molmil-images/mine/4n6w) | X-Ray Crystal Structure of Citrate-bound PhnZ | Descriptor: | CITRATE ANION, FE (III) ION, Predicted HD phosphohydrolase PhnZ | Authors: | Worsdorfer, B, Lingaraju, M, Yennawar, N.H, Boal, A.K, Krebs, C, Bollinger Jr, J.M, Pandelia, M.E. | Deposit date: | 2013-10-14 | Release date: | 2013-11-27 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases. Proc.Natl.Acad.Sci.USA, 110, 2013
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4N5C
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![BU of 4n5c by Molmil](/molmil-images/mine/4n5c) | Crystal structure of Ypp1 | Descriptor: | Cargo-transport protein YPP1 | Authors: | Wu, X, Chi, R.J, Baskin, J.M, Lucast, L, Burd, C.G, De Camilli, P, Reinisch, K.M. | Deposit date: | 2013-10-09 | Release date: | 2014-01-22 | Last modified: | 2014-03-19 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex. Dev.Cell, 28, 2014
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4NBK
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6CME
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![BU of 6cme by Molmil](/molmil-images/mine/6cme) | Structure of wild-type ISL2-LID in complex with LHX4-LIM1+2 | Descriptor: | LIM/homeobox protein Lhx4,Insulin gene enhancer protein ISL-2, ZINC ION | Authors: | Stokes, P.H, Silva, A, Guss, J.M, Matthews, J.M. | Deposit date: | 2018-03-04 | Release date: | 2019-04-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Mutation in a flexible linker modulates binding affinity for modular complexes. Proteins, 87, 2019
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5KZN
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![BU of 5kzn by Molmil](/molmil-images/mine/5kzn) | Metabotropic Glutamate Receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Metabotropic glutamate receptor 2 | Authors: | Chappell, M.D, Li, R, Smith, S.C, Dressman, B.A, Tromiczak, E.G, Tripp, A.E, Blanco, M.-J, Vetman, T, Quimby, S.J, Matt, J, Britton, T, Fivush, A.M, Schkeryantz, J.M, Mayhugh, D, Erickson, J.A, Bures, M, Jaramillo, C, Carpintero, M, de Diego, J.E, Barberis, M, Garcia-Cerrada, S, Soriano, J.F, Antonysamy, S, Atwell, S, MacEwan, I, Condon, B, Bradley, C, Wang, J, Zhang, A, Conners, K, Groshong, C, Wasserman, S.R, Koss, J.W, Witkin, J.M, Li, X, Overshiner, C, Wafford, K.A, Seidel, W, Wang, X.-S, Heinz, B.A, Swanson, S, Catlow, J, Bedwell, D, Monn, J.A, Mitch, C.H, Ornstein, P. | Deposit date: | 2016-07-25 | Release date: | 2016-12-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity. J. Med. Chem., 59, 2016
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6CAE
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![BU of 6cae by Molmil](/molmil-images/mine/6cae) | Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Pantel, L, Florin, T, Dobosz-Bartoszek, M, Racine, E, Sarciaux, M, Serri, M, Houard, J, Campagne, J.M, Marcia de Figueiredo, R, Midrier, C, Gaudriault, S, Givaudan, A, Lanois, A, Forst, S, Aumelas, A, Cotteaux-Lautard, C, Bolla, J.M, Vingsbo Lundberg, C, Huseby, D, Hughes, D, Villain-Guillot, P, Mankin, A.S, Polikanov, Y.S, Gualtieri, M. | Deposit date: | 2018-01-30 | Release date: | 2018-04-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site. Mol. Cell, 70, 2018
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5KZQ
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![BU of 5kzq by Molmil](/molmil-images/mine/5kzq) | Metabotropic Glutamate Receptor in complex with antagonist (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid | Descriptor: | (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 2 | Authors: | Chappell, M.D, Li, R, Smith, S.C, Dressman, B.A, Tromiczak, E.G, Tripp, A.E, Blanco, M.-J, Vetman, T, Quimby, S.J, Matt, J, Britton, T, Fivush, A.M, Schkeryantz, J.M, Mayhugh, D, Erickson, J.A, Bures, M, Jaramillo, C, Carpintero, M, de Diego, J.E, Barberis, M, Garcia-Cerrada, S, Soriano, J.F, Antonysamy, S, Atwell, S, MacEwan, I, Condon, B, Bradley, C, Wang, J, Zhang, A, Conners, K, Groshong, C, Wasserman, S.R, Koss, J.W, Witkin, J.M, Li, X, Overshiner, C, Wafford, K.A, Seidel, W, Wang, X.-S, Heinz, B.A, Swanson, S, Catlow, J, Bedwell, D, Monn, J.A, Mitch, C.H, Ornstein, P. | Deposit date: | 2016-07-25 | Release date: | 2016-12-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity. J. Med. Chem., 59, 2016
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6DDA
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![BU of 6dda by Molmil](/molmil-images/mine/6dda) | Nurr1 Covalently Modified by a Dopamine Metabolite | Descriptor: | 5-hydroxy-1,2-dihydro-6H-indol-6-one, BROMIDE ION, Nuclear receptor subfamily 4 group A member 2, ... | Authors: | Bruning, J.M, Wang, Y, Otrabella, F, Boxue, T, Liu, H, Bhattacharya, P, Guo, S, Holton, J.M, Fletterick, R.J, Jacobson, M.P, England, P.M. | Deposit date: | 2018-05-09 | Release date: | 2019-03-20 | Last modified: | 2019-11-06 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite. Cell Chem Biol, 26, 2019
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