4N48

Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Protein in complex with capped RNA fragment

Summary for 4N48

Related4N49 4N4A
DescriptorCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, capped RNA, S-ADENOSYLMETHIONINE, ... (5 entities in total)
Functional Keywordsmethyltransferase, mrna cap methylation, capped mrna, transferase-rna complex, transferase/rna
Biological sourceHomo sapiens (human)
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Cellular locationNucleus  Q8N1G2
Total number of polymer chains4
Total molecular weight102228.43
Authors
Smietanski, M.,Werener, M.,Purta, E.,Kaminska, K.H.,Stepinski, J.,Darzynkiewicz, E.,Nowotny, M.,Bujnicki, J.M. (deposition date: 2013-10-08, release date: 2014-01-22, Last modification date: 2018-01-24)
Primary citation
Smietanski, M.,Werner, M.,Purta, E.,Kaminska, K.H.,Stepinski, J.,Darzynkiewicz, E.,Nowotny, M.,Bujnicki, J.M.
Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation.
Nat Commun, 5:3004-3004, 2014
PubMed: 24402442 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms4004
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.704 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone0.24240.4%4.1%0.6%0.77MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4n48.pdb1.gz [70.74 KB])
Coordinate files for Biological unit (4n48.pdb2.gz [70.04 KB])