6CME

Structure of wild-type ISL2-LID in complex with LHX4-LIM1+2

Summary for 6CME

Entry DOI	10.2210/pdb6cme/pdb
Related	2JTN 2rgt 3mmk
Descriptor	LIM/homeobox protein Lhx4,Insulin gene enhancer protein ISL-2, ZINC ION (3 entities in total)
Functional Keywords	lim-homeodomain, cell-type specification, neural development, transcription
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	2
Total formula weight	38022.08
Authors	Stokes, P.H.,Silva, A.,Guss, J.M.,Matthews, J.M. (deposition date: 2018-03-04, release date: 2019-04-10, Last modification date: 2023-10-04)
Primary citation	Stokes, P.H.,Robertson, N.O.,Silva, A.P.G.,Estephan, T.,Trewhella, J.,Guss, J.M.,Matthews, J.M. Mutation in a flexible linker modulates binding affinity for modular complexes. Proteins, 87:425-429, 2019 Cited by PubMed: 30788856 DOI: 10.1002/prot.25675 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation