4ZJ8
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![BU of 4zj8 by Molmil](/molmil-images/mine/4zj8) | Structures of the human OX1 orexin receptor bound to selective and dual antagonists | Descriptor: | OLEIC ACID, [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, human OX1R fusion protein to P.abysii glycogen synthase | Authors: | Yin, J, Brautigam, C.A, Shao, Z, Clark, L, Harrell, C.M, Gotter, A.L, Coleman, P, Renger, J.J, Rosenbaum, D.M. | Deposit date: | 2015-04-29 | Release date: | 2016-03-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.751 Å) | Cite: | Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors. Nat.Struct.Mol.Biol., 23, 2016
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1A64
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6MS8
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![BU of 6ms8 by Molmil](/molmil-images/mine/6ms8) | Crystal Structure of Chalcone Isomerase from Medicago Truncatula Complexed with (2S) Naringenin | Descriptor: | Chalcone-flavonone isomerase family protein, NARINGENIN | Authors: | Burke, J.R, La Clair, J.J, Philippe, R.N, Pabis, A, Jez, J.M, Cortina, G, Kaltenbach, M, Bowman, M.E, Woods, K.B, Nelson, A.T, Tawfik, D.S, Kamerlin, S.C.L, Noel, J.P. | Deposit date: | 2018-10-16 | Release date: | 2019-08-21 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases Acs Catalysis, 2019
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6MVU
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1A6P
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1XF4
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![BU of 1xf4 by Molmil](/molmil-images/mine/1xf4) | Structure of ligand-free Fab DNA-1 in space group P321 solved from crystals with perfect hemihedral twinning | Descriptor: | Fab heavy chain, Fab light chain, SULFATE ION | Authors: | Schuermann, J.P, Prewitt, S.P, Deutscher, S.L, Tanner, J.J. | Deposit date: | 2004-09-13 | Release date: | 2005-04-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Evidence for Structural Plasticity of Heavy Chain Complementarity-determining Region 3 in Antibody-ssDNA Recognition J.Mol.Biol., 347, 2005
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5A32
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![BU of 5a32 by Molmil](/molmil-images/mine/5a32) | Electron cryo-microscopy of Cowpea Mosaic Virus containing RNA-1 (CPMVb) | Descriptor: | RNA2 POLYPROTEIN | Authors: | Hesketh, E.L, Meshcheriakova, Y, Dent, K.C, Saxena, P, Thompson, R, Cockburn, J.J, Lomonossoff, G.P, Ranson, N.A. | Deposit date: | 2015-05-27 | Release date: | 2015-12-23 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Mechanisms of assembly and genome packaging in an RNA virus revealed by high-resolution cryo-EM. Nat Commun, 6, 2015
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5A3I
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![BU of 5a3i by Molmil](/molmil-images/mine/5a3i) | Crystal Structure of a Complex formed between FLD194 Fab and Transmissible Mutant H5 Haemagglutinin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTI-HAEMAGGLUTININ HA1 FAB HEAVY CHAIN, ... | Authors: | Xiong, X, Corti, D, Liu, J, Pinna, D, Foglierini, M, Calder, L.J, Martin, S.R, Lin, Y.P, Walker, P.A, Collins, P.J, Monne, I, Suguitan Jr, A.L, Santos, C, Temperton, N.J, Subbarao, K, Lanzavecchia, A, Gamblin, S.J, Skehel, J.J. | Deposit date: | 2015-06-01 | Release date: | 2015-07-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Structures of Complexes Formed by H5 Influenza Hemagglutinin with a Potent Broadly Neutralizing Human Monoclonal Antibody. Proc.Natl.Acad.Sci.USA, 112, 2015
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6NY2
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![BU of 6ny2 by Molmil](/molmil-images/mine/6ny2) | CasX-gRNA-DNA(45bp) state I | Descriptor: | CasX, DNA Non-target strand, DNA target strand, ... | Authors: | Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A. | Deposit date: | 2019-02-10 | Release date: | 2019-02-27 | Last modified: | 2019-12-25 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | CasX enzymes comprise a distinct family of RNA-guided genome editors. Nature, 566, 2019
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5AGS
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![BU of 5ags by Molmil](/molmil-images/mine/5ags) | Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct 3-(Aminomethyl)-4-bromo-7-ethoxybenzo[c][1,2]oxaborol-1(3H)-ol-AMP | Descriptor: | 3-(AMINOMETHYL)-4-BROMO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-MODIFIED ADENOSINE, LEUCYL-TRNA SYNTHETASE, METHIONINE | Authors: | Palencia, A, Li, X, Alley, M.R.K, Ding, C, Easom, E.E, Hernandez, V, Meewan, M, Mohan, M, Rock, F.L, Franzblau, S.G, Wang, Y, Lenaerts, A.J, Parish, T, Cooper, C.B, Waters, M.G, Ma, Z, Mendoza, A, Barros, D, Cusack, S, Plattner, J.J. | Deposit date: | 2015-02-03 | Release date: | 2016-03-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60, 2016
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8DPX
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![BU of 8dpx by Molmil](/molmil-images/mine/8dpx) | Preligand association structure of DR5 | Descriptor: | Tumor necrosis factor receptor superfamily member 10B | Authors: | Du, G, Zhao, L, Chou, J.J. | Deposit date: | 2022-07-17 | Release date: | 2023-02-15 | Method: | SOLUTION NMR | Cite: | Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation. Cell Res., 33, 2023
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3CWL
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![BU of 3cwl by Molmil](/molmil-images/mine/3cwl) | Crystal structure of alpha-1-antitrypsin, crystal form B | Descriptor: | Alpha-1-antitrypsin, CHLORIDE ION | Authors: | Morton, C.J, Hansen, G, Feil, S.C, Adams, J.J, Parker, M.W. | Deposit date: | 2008-04-22 | Release date: | 2008-09-23 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding. Protein Sci., 17, 2008
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1Z1V
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![BU of 1z1v by Molmil](/molmil-images/mine/1z1v) | NMR structure of the Saccharomyces cerevisiae Ste50 SAM domain | Descriptor: | STE50 protein | Authors: | Kwan, J.J, Warner, N, Maini, J, Pawson, T, Donaldson, L.W. | Deposit date: | 2005-03-06 | Release date: | 2006-02-14 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Saccharomyces cerevisiae Ste50 binds the MAPKKK Ste11 through a head-to-tail SAM domain interaction. J.Mol.Biol., 356, 2006
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1Z25
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![BU of 1z25 by Molmil](/molmil-images/mine/1z25) | Structure of P.furiosus Argonaute with bound Mn2+ | Descriptor: | Argonaute, MANGANESE (II) ION | Authors: | Rivas, F.V, Tolia, N.H, Song, J.J, Aragon, J.P, Liu, J, Hannon, G.J, Joshua-Tor, L. | Deposit date: | 2005-03-07 | Release date: | 2005-04-05 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Purified Argonaute2 and an siRNA form recombinant human RISC. Nat.Struct.Mol.Biol., 12, 2005
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8EYC
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3CYO
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8E7F
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![BU of 8e7f by Molmil](/molmil-images/mine/8e7f) | Crystal structure of the autotransporter Ssp from Serratia marcescens. | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, Extracellular serine protease, ... | Authors: | Hor, L, Pilapitiya, A, Panjikar, S, Paxman, J.J, Heras, B. | Deposit date: | 2022-08-23 | Release date: | 2023-03-08 | Last modified: | 2023-03-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of a subtilisin-like autotransporter passenger domain reveals insights into its cytotoxic function. Nat Commun, 14, 2023
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1Z26
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![BU of 1z26 by Molmil](/molmil-images/mine/1z26) | Structure of Pyrococcus furiosus Argonaute with bound tungstate | Descriptor: | Argonaute, TUNGSTATE(VI)ION | Authors: | Rivas, F.V, Tolia, N.H, Song, J.J, Aragon, J.P, Liu, J, Hannon, G.J, Joshua-Tor, L. | Deposit date: | 2005-03-07 | Release date: | 2005-04-05 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Purified Argonaute2 and an siRNA form recombinant human RISC. Nat.Struct.Mol.Biol., 12, 2005
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5CDF
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![BU of 5cdf by Molmil](/molmil-images/mine/5cdf) | Structure at 2.3 A of the alpha/beta monomer of the F-ATPase from Paracoccus denitrificans | Descriptor: | ATP synthase subunit alpha, ATP synthase subunit beta, GLYCEROL, ... | Authors: | Morales-Rios, E, Montgomery, M.G, Leslie, A.G.W, Garcia-Trejo, J.J, Walker, J.E. | Deposit date: | 2015-07-03 | Release date: | 2015-10-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of a catalytic dimer of the alpha- and beta-subunits of the F-ATPase from Paracoccus denitrificans at 2.3 angstrom resolution. Acta Crystallogr.,Sect.F, 71, 2015
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8FNR
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8FNS
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4GOV
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![BU of 4gov by Molmil](/molmil-images/mine/4gov) | The crystal structure of human fascin 1 S39D mutant | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, BROMIDE ION, CHLORIDE ION, ... | Authors: | Yang, S.Y, Huang, F.K, Huang, J, Chen, S, Jakoncic, J, Leo-Macias, A, Diaz-Avalos, R, Chen, L, Zhang, J.J, Huang, X.Y. | Deposit date: | 2012-08-20 | Release date: | 2012-11-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Molecular mechanism of fascin function in filopodial formation. J.Biol.Chem., 288, 2013
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4GP0
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![BU of 4gp0 by Molmil](/molmil-images/mine/4gp0) | The crystal structure of human fascin 1 R149A K150A R151A mutant | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BROMIDE ION, ... | Authors: | Yang, S.Y, Huang, F.K, Huang, J, Chen, S, Jakoncic, J, Leo-Macias, A, Diaz-Avalos, R, Chen, L, Zhang, J.J, Huang, X.Y. | Deposit date: | 2012-08-20 | Release date: | 2012-11-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular mechanism of fascin function in filopodial formation. J.Biol.Chem., 288, 2013
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1XVJ
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![BU of 1xvj by Molmil](/molmil-images/mine/1xvj) | Crystal Structure Of Rat alpha-Parvalbumin D94S/G98E Mutant | Descriptor: | CALCIUM ION, Parvalbumin alpha | Authors: | Tanner, J.J, Agah, S, Lee, Y.H, Henzl, M.T. | Deposit date: | 2004-10-28 | Release date: | 2005-09-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of the D94S/G98E Variant of Rat alpha-Parvalbumin. An Explanation for the Reduced Divalent Ion Affinity. Biochemistry, 44, 2005
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6NTL
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![BU of 6ntl by Molmil](/molmil-images/mine/6ntl) | Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-234 | Descriptor: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, ... | Authors: | Bester, S.M, Guelta, M.A, Height, J.J, Pegan, S.D. | Deposit date: | 2019-01-29 | Release date: | 2020-07-01 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Insights into inhibition of human acetylcholinesterase by Novichok, A-series Nerve Agents To Be Published
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