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PDB: 2408 件
4ZJ8
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Structures of the human OX1 orexin receptor bound to selective and dual antagonists
分子名称: OLEIC ACID, [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, human OX1R fusion protein to P.abysii glycogen synthase
著者Yin, J, Brautigam, C.A, Shao, Z, Clark, L, Harrell, C.M, Gotter, A.L, Coleman, P, Renger, J.J, Rosenbaum, D.M.
登録日2015-04-29
公開日2016-03-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.751 Å)
主引用文献Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Nat.Struct.Mol.Biol., 23, 2016
1A64
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ENGINEERING A MISFOLDED FORM OF RAT CD2
分子名称: CD2
著者Murray, A.J, Head, J.G, Barker, J.J, Brady, R.L.
登録日1998-03-05
公開日1998-05-27
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Engineering an intertwined form of CD2 for stability and assembly.
Nat.Struct.Biol., 5, 1998
6MS8
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Crystal Structure of Chalcone Isomerase from Medicago Truncatula Complexed with (2S) Naringenin
分子名称: Chalcone-flavonone isomerase family protein, NARINGENIN
著者Burke, J.R, La Clair, J.J, Philippe, R.N, Pabis, A, Jez, J.M, Cortina, G, Kaltenbach, M, Bowman, M.E, Woods, K.B, Nelson, A.T, Tawfik, D.S, Kamerlin, S.C.L, Noel, J.P.
登録日2018-10-16
公開日2019-08-21
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases
Acs Catalysis, 2019
6MVU
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Structure of a bacterial ALDH16 active site mutant C295A complexed with p-nitrophenylacetate
分子名称: 4-nitrophenyl acetate, Aldehyde dehydrogenase, GLYCEROL, ...
著者Tanner, J.J, Liu, L.
登録日2018-10-28
公開日2018-12-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.488 Å)
主引用文献Crystal Structure of Aldehyde Dehydrogenase 16 Reveals Trans-Hierarchical Structural Similarity and a New Dimer.
J. Mol. Biol., 431, 2019
1A6P
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BU of 1a6p by Molmil
ENGINEERING OF A MISFOLDED FORM OF CD2
分子名称: T-CELL SURFACE ANTIGEN CD2
著者Murray, A.J, Head, J.G, Barker, J.J, Brady, R.L.
登録日1998-02-26
公開日1998-06-17
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Engineering an intertwined form of CD2 for stability and assembly.
Nat.Struct.Biol., 5, 1998
1XF4
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BU of 1xf4 by Molmil
Structure of ligand-free Fab DNA-1 in space group P321 solved from crystals with perfect hemihedral twinning
分子名称: Fab heavy chain, Fab light chain, SULFATE ION
著者Schuermann, J.P, Prewitt, S.P, Deutscher, S.L, Tanner, J.J.
登録日2004-09-13
公開日2005-04-12
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Evidence for Structural Plasticity of Heavy Chain Complementarity-determining Region 3 in Antibody-ssDNA Recognition
J.Mol.Biol., 347, 2005
5A32
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BU of 5a32 by Molmil
Electron cryo-microscopy of Cowpea Mosaic Virus containing RNA-1 (CPMVb)
分子名称: RNA2 POLYPROTEIN
著者Hesketh, E.L, Meshcheriakova, Y, Dent, K.C, Saxena, P, Thompson, R, Cockburn, J.J, Lomonossoff, G.P, Ranson, N.A.
登録日2015-05-27
公開日2015-12-23
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.44 Å)
主引用文献Mechanisms of assembly and genome packaging in an RNA virus revealed by high-resolution cryo-EM.
Nat Commun, 6, 2015
5A3I
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Crystal Structure of a Complex formed between FLD194 Fab and Transmissible Mutant H5 Haemagglutinin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTI-HAEMAGGLUTININ HA1 FAB HEAVY CHAIN, ...
著者Xiong, X, Corti, D, Liu, J, Pinna, D, Foglierini, M, Calder, L.J, Martin, S.R, Lin, Y.P, Walker, P.A, Collins, P.J, Monne, I, Suguitan Jr, A.L, Santos, C, Temperton, N.J, Subbarao, K, Lanzavecchia, A, Gamblin, S.J, Skehel, J.J.
登録日2015-06-01
公開日2015-07-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Structures of Complexes Formed by H5 Influenza Hemagglutinin with a Potent Broadly Neutralizing Human Monoclonal Antibody.
Proc.Natl.Acad.Sci.USA, 112, 2015
6NY2
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CasX-gRNA-DNA(45bp) state I
分子名称: CasX, DNA Non-target strand, DNA target strand, ...
著者Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A.
登録日2019-02-10
公開日2019-02-27
最終更新日2019-12-25
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
5AGS
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BU of 5ags by Molmil
Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct 3-(Aminomethyl)-4-bromo-7-ethoxybenzo[c][1,2]oxaborol-1(3H)-ol-AMP
分子名称: 3-(AMINOMETHYL)-4-BROMO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-MODIFIED ADENOSINE, LEUCYL-TRNA SYNTHETASE, METHIONINE
著者Palencia, A, Li, X, Alley, M.R.K, Ding, C, Easom, E.E, Hernandez, V, Meewan, M, Mohan, M, Rock, F.L, Franzblau, S.G, Wang, Y, Lenaerts, A.J, Parish, T, Cooper, C.B, Waters, M.G, Ma, Z, Mendoza, A, Barros, D, Cusack, S, Plattner, J.J.
登録日2015-02-03
公開日2016-03-09
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
8DPX
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BU of 8dpx by Molmil
Preligand association structure of DR5
分子名称: Tumor necrosis factor receptor superfamily member 10B
著者Du, G, Zhao, L, Chou, J.J.
登録日2022-07-17
公開日2023-02-15
実験手法SOLUTION NMR
主引用文献Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation.
Cell Res., 33, 2023
3CWL
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BU of 3cwl by Molmil
Crystal structure of alpha-1-antitrypsin, crystal form B
分子名称: Alpha-1-antitrypsin, CHLORIDE ION
著者Morton, C.J, Hansen, G, Feil, S.C, Adams, J.J, Parker, M.W.
登録日2008-04-22
公開日2008-09-23
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
1Z1V
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BU of 1z1v by Molmil
NMR structure of the Saccharomyces cerevisiae Ste50 SAM domain
分子名称: STE50 protein
著者Kwan, J.J, Warner, N, Maini, J, Pawson, T, Donaldson, L.W.
登録日2005-03-06
公開日2006-02-14
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Saccharomyces cerevisiae Ste50 binds the MAPKKK Ste11 through a head-to-tail SAM domain interaction.
J.Mol.Biol., 356, 2006
1Z25
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BU of 1z25 by Molmil
Structure of P.furiosus Argonaute with bound Mn2+
分子名称: Argonaute, MANGANESE (II) ION
著者Rivas, F.V, Tolia, N.H, Song, J.J, Aragon, J.P, Liu, J, Hannon, G.J, Joshua-Tor, L.
登録日2005-03-07
公開日2005-04-05
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Purified Argonaute2 and an siRNA form recombinant human RISC.
Nat.Struct.Mol.Biol., 12, 2005
8EYC
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BU of 8eyc by Molmil
Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with TYK2 activation loop phosphopeptide
分子名称: Non-receptor tyrosine-protein kinase TYK2 activation loop phosphopeptide, Tyrosine-protein phosphatase non-receptor type 1
著者Morris, R, Kershaw, N.J, Babon, J.J.
登録日2022-10-26
公開日2023-08-16
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
3CYO
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BU of 3cyo by Molmil
Structure of a longer thermalstable core domain of HIV-1 GP41 containing the enfuvirtide resistance mutation N43D and complementary mutation E137K
分子名称: Transmembrane protein
著者Wang, Z.M, Dwyer, J.J.
登録日2008-04-25
公開日2008-06-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Impact of the enfuvirtide resistance mutation N43D and the associated baseline polymorphism E137K on peptide sensitivity and six-helix bundle structure.
Biochemistry, 47, 2008
8E7F
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Crystal structure of the autotransporter Ssp from Serratia marcescens.
分子名称: CALCIUM ION, DI(HYDROXYETHYL)ETHER, Extracellular serine protease, ...
著者Hor, L, Pilapitiya, A, Panjikar, S, Paxman, J.J, Heras, B.
登録日2022-08-23
公開日2023-03-08
最終更新日2023-03-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of a subtilisin-like autotransporter passenger domain reveals insights into its cytotoxic function.
Nat Commun, 14, 2023
1Z26
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Structure of Pyrococcus furiosus Argonaute with bound tungstate
分子名称: Argonaute, TUNGSTATE(VI)ION
著者Rivas, F.V, Tolia, N.H, Song, J.J, Aragon, J.P, Liu, J, Hannon, G.J, Joshua-Tor, L.
登録日2005-03-07
公開日2005-04-05
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Purified Argonaute2 and an siRNA form recombinant human RISC.
Nat.Struct.Mol.Biol., 12, 2005
5CDF
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Structure at 2.3 A of the alpha/beta monomer of the F-ATPase from Paracoccus denitrificans
分子名称: ATP synthase subunit alpha, ATP synthase subunit beta, GLYCEROL, ...
著者Morales-Rios, E, Montgomery, M.G, Leslie, A.G.W, Garcia-Trejo, J.J, Walker, J.E.
登録日2015-07-03
公開日2015-10-07
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of a catalytic dimer of the alpha- and beta-subunits of the F-ATPase from Paracoccus denitrificans at 2.3 angstrom resolution.
Acta Crystallogr.,Sect.F, 71, 2015
8FNR
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X-ray crystal structure of Hansschlegelia quercus lanmodulin (LanM) with dysprosium (III) bound at pH 7
分子名称: DYSPROSIUM ION, EF-hand domain-containing protein
著者Jung, J.J, Lin, C.-Y, Boal, A.K.
登録日2022-12-28
公開日2023-06-07
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Enhanced rare-earth separation with a metal-sensitive lanmodulin dimer.
Nature, 618, 2023
8FNS
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X-ray crystal structure of Methylorubrum extorquens AM1 lanmodulin (LanM) with neodymium (III) bound at pH 7
分子名称: EF-hand domain-containing protein, Neodymium Ion
著者Jung, J.J, Lin, C.-Y, Boal, A.K.
登録日2022-12-28
公開日2023-06-07
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.01 Å)
主引用文献Enhanced rare-earth separation with a metal-sensitive lanmodulin dimer.
Nature, 618, 2023
4GOV
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BU of 4gov by Molmil
The crystal structure of human fascin 1 S39D mutant
分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, BROMIDE ION, CHLORIDE ION, ...
著者Yang, S.Y, Huang, F.K, Huang, J, Chen, S, Jakoncic, J, Leo-Macias, A, Diaz-Avalos, R, Chen, L, Zhang, J.J, Huang, X.Y.
登録日2012-08-20
公開日2012-11-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Molecular mechanism of fascin function in filopodial formation.
J.Biol.Chem., 288, 2013
4GP0
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The crystal structure of human fascin 1 R149A K150A R151A mutant
分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BROMIDE ION, ...
著者Yang, S.Y, Huang, F.K, Huang, J, Chen, S, Jakoncic, J, Leo-Macias, A, Diaz-Avalos, R, Chen, L, Zhang, J.J, Huang, X.Y.
登録日2012-08-20
公開日2012-11-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular mechanism of fascin function in filopodial formation.
J.Biol.Chem., 288, 2013
1XVJ
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Crystal Structure Of Rat alpha-Parvalbumin D94S/G98E Mutant
分子名称: CALCIUM ION, Parvalbumin alpha
著者Tanner, J.J, Agah, S, Lee, Y.H, Henzl, M.T.
登録日2004-10-28
公開日2005-09-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structure of the D94S/G98E Variant of Rat alpha-Parvalbumin. An Explanation for the Reduced Divalent Ion Affinity.
Biochemistry, 44, 2005
6NTL
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Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-234
分子名称: 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, ...
著者Bester, S.M, Guelta, M.A, Height, J.J, Pegan, S.D.
登録日2019-01-29
公開日2020-07-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Insights into inhibition of human acetylcholinesterase by Novichok, A-series Nerve Agents
To Be Published

224004

件を2024-08-21に公開中

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