4O0W
 
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3GR4
 | | Activator-Bound Structure of Human Pyruvate Kinase M2 | | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Hong, B, Dimov, S, Tempel, W, Auld, D, Thomas, C, Boxer, M, Jianq, J.-K, Skoumbourdis, A, Min, S, Southall, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Inglese, J, Park, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2009-03-24 | | Release date: | 2009-04-07 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Activator-Bound Structures of Human Pyruvate Kinase M2
to be published
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4NNH
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6F27
 | | NMR solution structure of non-bound [des-Arg10]-kallidin (DAKD) | | Descriptor: | DAKD | | Authors: | Richter, C, Jonker, H.R.A, Schwalbe, H, Joedicke, L, Mao, J, Kuenze, G, Reinhart, C, Kalavacherla, T, Meiler, J, Preu, J, Michel, H, Glaubitz, C. | | Deposit date: | 2017-11-23 | | Release date: | 2018-01-10 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
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3GQY
 | | Activator-Bound Structure of Human Pyruvate Kinase M2 | | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine, L(+)-TARTARIC ACID, ... | | Authors: | Hong, B, Dimov, S, Tempel, W, Auld, D, Thomas, C, Boxer, M, Jianq, J.-K, Skoumbourdis, A, Min, S, Southall, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Inglese, J, Park, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2009-03-24 | | Release date: | 2009-04-07 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Activator-Bound Structures of Human Pyruvate Kinase M2
to be published
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6OSJ
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5G3S
 | | The structure of the L-tryptophan oxidase VioA from Chromobacterium violaceum - Samarium derivative | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ... | | Authors: | Krausze, J, Rabe, J, Moser, J. | | Deposit date: | 2016-05-01 | | Release date: | 2016-08-03 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.076 Å) | | Cite: | Biosynthesis of Violacein: Structure and Function of L-Tryptophan Oxidase Vioa Chromobacterium Violaceum
J.Biol.Chem., 291, 2016
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6OVG
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1MHW
 | | Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides | | Descriptor: | 4-biphenylacetyl-Cys-(D)Arg-Tyr-N-(2-phenylethyl) amide, Cathepsin L | | Authors: | Chowdhury, S, Sivaraman, J, Wang, J, Devanathan, G, Lachance, P, Qi, H, Menard, R, Lefebvre, J, Konishi, Y, Cygler, M, Sulea, T, Purisima, E.O. | | Deposit date: | 2002-08-21 | | Release date: | 2002-12-11 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides
J.Med.Chem., 45, 2002
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9EQ1
 | | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGJM24 | | Descriptor: | 1,2-ETHANEDIOL, Casein kinase II subunit alpha, SULFATE ION, ... | | Authors: | Kraemer, A, Greco, F, Moeckel, J, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2024-03-20 | | Release date: | 2024-05-01 | | Last modified: | 2024-08-07 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Synthesis and evaluation of chemical linchpins for highly selective CK2 alpha targeting.
Eur.J.Med.Chem., 276, 2024
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5G3T
 | | The structure of the L-tryptophan oxidase VioA from Chromobacterium violaceum | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ... | | Authors: | Krausze, J, Rabe, J, Moser, J. | | Deposit date: | 2016-05-01 | | Release date: | 2016-08-03 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Biosynthesis of Violacein: Structure and Function of L-Tryptophan Oxidase Vioa Chromobacterium Violaceum
J.Biol.Chem., 291, 2016
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8DKU
 | | CryoEM structure of the A. aeolicus WzmWzt transporter bound to the native O antigen | | Descriptor: | 6-deoxy-3-O-methyl-alpha-D-mannopyranose-(1-3)-beta-D-rhamnopyranose-(1-2)-alpha-D-rhamnopyranose, ABC transporter, Transport permease protein | | Authors: | Spellmon, N, Muszynski, A, Vlach, J, Zimmer, J. | | Deposit date: | 2022-07-06 | | Release date: | 2022-09-21 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Molecular basis for polysaccharide recognition and modulated ATP hydrolysis by the O antigen ABC transporter.
Nat Commun, 13, 2022
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8DNC
 | | CryoEM structure of the A. aeolicus WzmWzt transporter bound to the native O antigen and ADP | | Descriptor: | 6-deoxy-3-O-methyl-alpha-D-mannopyranose-(1-3)-beta-D-rhamnopyranose-(1-2)-alpha-D-rhamnopyranose, ABC transporter, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Spellmon, N, Muszynski, A, Vlach, J, Zimmer, J. | | Deposit date: | 2022-07-11 | | Release date: | 2022-09-21 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Molecular basis for polysaccharide recognition and modulated ATP hydrolysis by the O antigen ABC transporter.
Nat Commun, 13, 2022
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3H2S
 | | Crystal Structure of the Q03B84 Protein from Lactobacillus casei. Northeast Structural Genomics Consortium Target LcR19. | | Descriptor: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Putative NADH-flavin reductase | | Authors: | Vorobiev, S, Lew, S, Seetharaman, J, Wang, D, Ciccosanti, C, Sahdev, S, Acton, T.B, Xiao, R, Everett, J, Nair, R, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2009-04-14 | | Release date: | 2009-04-28 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Crystal structure of the Q03B84 protein from Lactobacillus casei.
To be Published
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8PK7
 | | Helical reconstruction of CHIKV nsP3 helical scaffolds | | Descriptor: | Non-structural protein 3, ZINC ION | | Authors: | Reguera, J, Hons, M, Zimberger, C, Ptchelkine, D, Jones, R, Desfosses, A. | | Deposit date: | 2023-06-25 | | Release date: | 2024-08-14 | | Last modified: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (2.52 Å) | | Cite: | Alphavirus nsP3 organizes into tubular scaffolds essential for infection and the cytoplasmic granule architecture.
Nat Commun, 15, 2024
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8PHZ
 | | Helical reconstruction of CHIKV nsP3 helical scaffolds | | Descriptor: | Non-structural protein 3, ZINC ION | | Authors: | Reguera, J, Hons, M, Zimberger, C, Ptchelkine, D, Jones, R, Desfosses, A. | | Deposit date: | 2023-06-20 | | Release date: | 2024-08-14 | | Last modified: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (2.35 Å) | | Cite: | Alphavirus nsP3 organizes into tubular scaffolds essential for infection and the cytoplasmic granule architecture.
Nat Commun, 15, 2024
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8POX
 | | Crystal Structure of the C19G variant of the membrane-bound [NiFe]-Hydrogenase from Cupriavidus necator in the H2-reduced state at 1.6 A Resolution. | | Descriptor: | CHLORIDE ION, FE3-S4 CLUSTER, Fe4S4, ... | | Authors: | Kalms, J, Schmidt, A, Scheerer, P. | | Deposit date: | 2023-07-05 | | Release date: | 2024-09-18 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Stepwise conversion of the Cys 6 [4Fe-3S] to a Cys 4 [4Fe-4S] cluster and its impact on the oxygen tolerance of [NiFe]-hydrogenase.
Chem Sci, 14, 2023
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8POZ
 | | Crystal Structure of the C120G variant of the membrane-bound [NiFe]-Hydrogenase from Cupriavidus necator in the H2-reduced state at 1.65 A Resolution. | | Descriptor: | CHLORIDE ION, FE3-S4 CLUSTER, FE4-S3 CLUSTER, ... | | Authors: | Schmidt, A, Kalms, J, Scheerer, P. | | Deposit date: | 2023-07-05 | | Release date: | 2024-09-18 | | Last modified: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Stepwise conversion of the Cys 6 [4Fe-3S] to a Cys 4 [4Fe-4S] cluster and its impact on the oxygen tolerance of [NiFe]-hydrogenase.
Chem Sci, 14, 2023
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8PA0
 | | cvHsp (HspB7) C131S alpha-crystallin domain - filamin C (FLNC) domain 24 complex | | Descriptor: | Filamin-C, Heat shock protein beta-7 | | Authors: | Wang, Z, Benesch, J.L.P, Allison, T.M, Song, H, McDonough, M.A, Brem, J, Rabe, P. | | Deposit date: | 2023-06-06 | | Release date: | 2024-10-16 | | Last modified: | 2025-05-14 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Filamin C dimerisation is regulated by HSPB7.
Nat Commun, 16, 2025
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4YMX
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4NNI
 | | Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide | | Descriptor: | 30S ribosomal protein S1, PYRAZINE-2-CARBOXYLIC ACID | | Authors: | Yang, J, Liu, Y, Cai, Q, Lin, D. | | Deposit date: | 2013-11-18 | | Release date: | 2014-12-24 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.64 Å) | | Cite: | Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide.
Mol.Microbiol., 95, 2015
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8PPX
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8POY
 | | Crystal Structure of the C120G variant of the membrane-bound [NiFe]-Hydrogenase from Cupriavidus necator in the air-oxidized state at 1.93 A Resolution. | | Descriptor: | CHLORIDE ION, FE3-S4 CLUSTER, FE4-S3 CLUSTER, ... | | Authors: | Schmidt, A, Kalms, J, Scheerer, P. | | Deposit date: | 2023-07-05 | | Release date: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Stepwise conversion of the Cys 6 [4Fe-3S] to a Cys 4 [4Fe-4S] cluster and its impact on the oxygen tolerance of [NiFe]-hydrogenase.
Chem Sci, 14, 2023
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8V1T
 | | Herpes simplex virus 1 polymerase holoenzyme bound to DNA and acyclovir triphosphate in closed conformation | | Descriptor: | ACYCLOVIR TRIPHOSPHATE, DNA polymerase, DNA polymerase processivity factor, ... | | Authors: | Pan, J, Abraham, J, Coen, D.M, Shankar, S, Yang, P, Hogle, J. | | Deposit date: | 2023-11-21 | | Release date: | 2024-09-04 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance.
Cell, 187, 2024
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8Q7R
 | | Ubiquitin ligation to substrate by a cullin-RING E3 ligase & Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2~donor UB-Sil1 peptide | | Descriptor: | 5-azanyl-1-oxidanyl-pentan-2-one, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | | Authors: | Liwocha, J, Prabu, J.R, Kleiger, G, Schulman, B.A. | | Deposit date: | 2023-08-16 | | Release date: | 2024-02-21 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting.
Mol.Cell, 84, 2024
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