7MDN
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![BU of 7mdn by Molmil](/molmil-images/mine/7mdn) | Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a | Descriptor: | Histone-lysine N-methyltransferase NSD2, UNKNOWN ATOM OR ION, ~{N}-cyclopropyl-3-oxidanylidene-~{N}-(thiophen-2-ylmethyl)-4~{H}-1,4-benzoxazine-7-carboxamide | Authors: | Lei, M, Freitas, R.F, Dong, A, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2021-04-05 | Release date: | 2021-05-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nat.Chem.Biol., 18, 2022
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3UJK
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![BU of 3ujk by Molmil](/molmil-images/mine/3ujk) | Crystal structure of protein phosphatase ABI2 | Descriptor: | MAGNESIUM ION, Protein phosphatase 2C 77 | Authors: | Zhou, X.E, Soon, F.-F, Ng, L.-M, Kovach, A, Tan, M.H.E, Suino-Powell, K.M, He, Y, Xu, Y, Brunzelle, J.S, Li, J, Melcher, K, Xu, H.E. | Deposit date: | 2011-11-07 | Release date: | 2012-02-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science, 335, 2012
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6KQY
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![BU of 6kqy by Molmil](/molmil-images/mine/6kqy) | Crystal structure of human leucyl-tRNA synthetase, Leucine-bound form | Descriptor: | LEUCINE, Leucine--tRNA ligase, cytoplasmic, ... | Authors: | Kim, S, Son, J, Kim, S, Hwang, K.Y. | Deposit date: | 2019-08-20 | Release date: | 2021-01-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation. Cell Rep, 35, 2021
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6KR7
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![BU of 6kr7 by Molmil](/molmil-images/mine/6kr7) | Crystal structure of methylated human leucyl-tRNA synthetase, Leu-AMS-bound form | Descriptor: | 5'-O-(L-leucylsulfamoyl)adenosine, LEUCINE, Leucine--tRNA ligase, ... | Authors: | Kim, S, Son, J, Kim, S, Hwang, K.Y. | Deposit date: | 2019-08-21 | Release date: | 2021-01-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation. Cell Rep, 35, 2021
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8T8B
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![BU of 8t8b by Molmil](/molmil-images/mine/8t8b) | Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MAI-tripeptidyl-tRNA analog ACCA-IAMf at 2.65A resolution | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | Authors: | Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R. | Deposit date: | 2023-06-22 | Release date: | 2023-07-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics. Acs Chem.Biol., 18, 2023
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6KUU
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![BU of 6kuu by Molmil](/molmil-images/mine/6kuu) | Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B3) | Descriptor: | 3'-vRNA, 5'-vRNA, Polymerase 3, ... | Authors: | Peng, Q, Peng, R, Qi, J, Gao, G.F, Shi, Y. | Deposit date: | 2019-09-02 | Release date: | 2019-12-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B3) To Be Published
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8T8C
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![BU of 8t8c by Molmil](/molmil-images/mine/8t8c) | Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MFI-tripeptidyl-tRNA analog ACCA-IFMf at 2.60A resolution | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | Authors: | Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R. | Deposit date: | 2023-06-22 | Release date: | 2023-07-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics. Acs Chem.Biol., 18, 2023
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6L9B
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![BU of 6l9b by Molmil](/molmil-images/mine/6l9b) | X-ray structure of synthetic GB1 domain with mutations K10(DVA), T11A | Descriptor: | Immunoglobulin G-binding protein G | Authors: | Penmatsa, A, Chatterjee, J, Khatri, B, Majumder, P. | Deposit date: | 2019-11-08 | Release date: | 2020-08-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Increasing protein stability by engineering the n -> pi * interaction at the beta-turn. Chem Sci, 11, 2020
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7Y8G
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![BU of 7y8g by Molmil](/molmil-images/mine/7y8g) | Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with an Inhibitor 30a and GRIP Peptide | Descriptor: | DI(HYDROXYETHYL)ETHER, Estrogen receptor, Grip peptide, ... | Authors: | Min, J, Hu, H.B, Yang, Y, Dong, C.E, Zhou, H.B, Chen, C.-C, Guo, R.-T. | Deposit date: | 2022-06-23 | Release date: | 2023-04-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Structure-guided identification of novel dual-targeting estrogen receptor alpha degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer. Eur.J.Med.Chem., 253, 2023
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7Y8F
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![BU of 7y8f by Molmil](/molmil-images/mine/7y8f) | Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with an Inhibitor 30o and GRIP Peptide | Descriptor: | DI(HYDROXYETHYL)ETHER, Estrogen receptor, Grip peptide, ... | Authors: | Min, J, Hu, H.B, Yang, Y, Dong, C.E, Zhou, H.B, Chen, C.-C, Guo, R.-T. | Deposit date: | 2022-06-23 | Release date: | 2023-04-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Structure-guided identification of novel dual-targeting estrogen receptor alpha degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer. Eur.J.Med.Chem., 253, 2023
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5ECE
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![BU of 5ece by Molmil](/molmil-images/mine/5ece) | Tankyrase 1 with Phthalazinone 1 | Descriptor: | 1,2-ETHANEDIOL, 2-[4-[3-[(4-oxidanylidene-3~{H}-phthalazin-1-yl)methyl]phenyl]carbonylpiperazin-1-yl]pyridine-3-carbonitrile, ACETATE ION, ... | Authors: | Kazmirski, S.L, Johannes, J, Read, J.A, Howard, T, Larsen, N.A, Ferguson, A.D. | Deposit date: | 2015-10-20 | Release date: | 2015-11-25 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering. Bioorg.Med.Chem.Lett., 25, 2015
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6KSH
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![BU of 6ksh by Molmil](/molmil-images/mine/6ksh) | Crystal structure of pyruvate kinase (PYK) from Plasmodium falciparum in complex with oxalate and ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, OXALATE ION, ... | Authors: | Zhong, W, Cai, Q, Li, K, Lescar, J, Dedon, P.C. | Deposit date: | 2019-08-23 | Release date: | 2020-08-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Pyruvate kinase from Plasmodium falciparum: Structural and kinetic insights into the allosteric mechanism. Biochem.Biophys.Res.Commun., 532, 2020
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6L3T
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![BU of 6l3t by Molmil](/molmil-images/mine/6l3t) | Human Cx31.3/GJC3 connexin hemichannel in the absence of calcium | Descriptor: | Gap junction gamma-3 protein, Lauryl Maltose Neopentyl Glycol | Authors: | Lee, H.J, Jeong, H, Ryu, B, Hyun, J, Woo, J.S. | Deposit date: | 2019-10-15 | Release date: | 2020-09-09 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (2.34 Å) | Cite: | Cryo-EM structure of human Cx31.3/GJC3 connexin hemichannel. Sci Adv, 6, 2020
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6L8Z
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![BU of 6l8z by Molmil](/molmil-images/mine/6l8z) | Crystal structure of ugt transferase mutant in complex with UPG | Descriptor: | Glycosyltransferase, URIDINE-5'-DIPHOSPHATE-GLUCOSE | Authors: | Li, J, Shan, N, Yang, J.G, Liu, W.D, Sun, Y.X. | Deposit date: | 2019-11-07 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Efficient O-Glycosylation of Triterpenes Enabled by Protein Engineering of Plant Glycosyltransferase UGT74AC1 Acs Catalysis, 2020
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4UOE
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![BU of 4uoe by Molmil](/molmil-images/mine/4uoe) | Crystal Structure of Plasmodium Falciparum Spermidine Synthase in Complex with 5'-Deoxy-5'-Methylioadenosine and 4-Aminomethylaniline | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 4-(aminomethyl)aniline, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ... | Authors: | Sprenger, J, Halander, J.C, Svensson, B, Al-Karadaghi, S, Person, L. | Deposit date: | 2014-06-03 | Release date: | 2014-10-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Three-Dimensional Structures of Plasmodium Falciparum Spermidine Synthase with Bound Inhibitors Suggest New Strategies for Drug Design. Acta Crystallogr.,Sect.D, 71, 2015
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6LDQ
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![BU of 6ldq by Molmil](/molmil-images/mine/6ldq) | |
6L9D
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![BU of 6l9d by Molmil](/molmil-images/mine/6l9d) | X-ray structure of synthetic GB1 domain with mutations K10(DVA), T11S | Descriptor: | Immunoglobulin G-binding protein G | Authors: | Penmatsa, A, Chatterjee, J, Majumder, P, Khatri, B. | Deposit date: | 2019-11-08 | Release date: | 2020-08-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Increasing protein stability by engineering the n -> pi * interaction at the beta-turn. Chem Sci, 11, 2020
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4V48
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![BU of 4v48 by Molmil](/molmil-images/mine/4v48) | Real space refined coordinates of the 30S and 50S subunits fitted into the low resolution cryo-EM map of the initiation-like state of E. coli 70S ribosome | Descriptor: | 16S RIBOSOMAL RNA, 23S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, ... | Authors: | Gao, H, Sengupta, J, Valle, M, Korostelev, A, Eswar, N, Stagg, S.M, Van Roey, P, Agrawal, R.K, Harvey, S.T, Sali, A, Chapman, M.S, Frank, J. | Deposit date: | 2003-05-06 | Release date: | 2014-07-09 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (11.5 Å) | Cite: | Study of the structural dynamics of the E. coli 70S ribosome using real space refinement Cell(Cambridge,Mass.), 113, 2003
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4V4B
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![BU of 4v4b by Molmil](/molmil-images/mine/4v4b) | Structure of the ribosomal 80S-eEF2-sordarin complex from yeast obtained by docking atomic models for RNA and protein components into a 11.7 A cryo-EM map. | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S11, ... | Authors: | Spahn, C.M, Gomez-Lorenzo, M.G, Grassucci, R.A, Jorgensen, R, Andersen, G.R, Beckmann, R, Penczek, P.A, Ballesta, J.P.G, Frank, J. | Deposit date: | 2004-01-06 | Release date: | 2014-07-09 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (11.7 Å) | Cite: | Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation. Embo J., 23, 2004
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6Z0V
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![BU of 6z0v by Molmil](/molmil-images/mine/6z0v) | |
6YT2
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![BU of 6yt2 by Molmil](/molmil-images/mine/6yt2) | Crystal Structure of human monoamine oxidase B in complex with Diphenylene iodonium (DPI) | Descriptor: | Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Iacovino, L.G, Reis, J, Mai, A, Mattevi, A, Binda, C. | Deposit date: | 2020-04-23 | Release date: | 2020-06-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Diphenylene Iodonium Is a Noncovalent MAO Inhibitor: A Biochemical and Structural Analysis. Chemmedchem, 15, 2020
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6Z80
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![BU of 6z80 by Molmil](/molmil-images/mine/6z80) | stimulatory human GTP cyclohydrolase I - GFRP complex | Descriptor: | 8-OXO-GUANOSINE-5'-TRIPHOSPHATE, GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ... | Authors: | Ebenhoch, R, Nar, H, Vonck, J. | Deposit date: | 2020-06-02 | Release date: | 2020-12-09 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
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6YWO
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![BU of 6ywo by Molmil](/molmil-images/mine/6ywo) | CutA in complex with A3 RNA | Descriptor: | CHLORIDE ION, CutA, MAGNESIUM ION, ... | Authors: | Malik, D, Kobylecki, K, Krawczyk, P, Poznanski, J, Jakielaszek, A, Napiorkowska, A, Dziembowski, A, Tomecki, R, Nowotny, M. | Deposit date: | 2020-04-29 | Release date: | 2020-08-05 | Last modified: | 2020-09-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure and mechanism of CutA, RNA nucleotidyl transferase with an unusual preference for cytosine. Nucleic Acids Res., 48, 2020
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6YZ1
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![BU of 6yz1 by Molmil](/molmil-images/mine/6yz1) | The crystal structure of SARS-CoV-2 nsp10-nsp16 methyltransferase complex with Sinefungin | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SINEFUNGIN, ZINC ION, ... | Authors: | Krafcikova, P, Silhan, J, Nencka, R, Boura, E. | Deposit date: | 2020-05-06 | Release date: | 2020-05-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin. Nat Commun, 11, 2020
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6Z20
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![BU of 6z20 by Molmil](/molmil-images/mine/6z20) | Structure of the EC2 domain of CD9 in complex with nanobody 4C8 | Descriptor: | CD9 antigen, CHLORIDE ION, GLYCEROL, ... | Authors: | Oosterheert, W, Manshande, J, Pearce, N.M, Lutz, M, Gros, P. | Deposit date: | 2020-05-14 | Release date: | 2020-09-23 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F. Life Sci Alliance, 3, 2020
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