4UOE

Crystal Structure of Plasmodium Falciparum Spermidine Synthase in Complex with 5'-Deoxy-5'-Methylioadenosine and 4-Aminomethylaniline

Replaces:  4BNO

Summary for 4UOE

• Entry DOI: 10.2210/pdb4uoe/pdb
• Descriptor: SPERMIDINE SYNTHASE, 5'-DEOXY-5'-METHYLTHIOADENOSINE, 4-(aminomethyl)aniline, ... (6 entities in total)
• Functional Keywords: transferase, aminopropyl transferase, polyamine pathway, rossmann-like fold
• Biological source: PLASMODIUM FALCIPARUM
• Total number of polymer chains: 3
• Total formula weight: 97926.06

Authors

Sprenger, J.,Halander, J.C.,Svensson, B.,Al-Karadaghi, S.,Person, L. (deposition date: 2014-06-03, release date: 2014-10-08, Last modification date: 2024-01-10)

• Primary citation: Sprenger, J.,Svensson, B.,Halander, J.,Carey, J.,Persson, L.,Al-Karadaghi, S.; Three-Dimensional Structures of Plasmodium Falciparum Spermidine Synthase with Bound Inhibitors Suggest New Strategies for Drug Design.; Acta Crystallogr.,Sect.D, 71:484-, 2015; PubMed: 25760598; DOI: 10.1107/S1399004714027011

Experimental method

X-RAY DIFFRACTION (2.05 Å)