7Y8F

Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with an Inhibitor 30o and GRIP Peptide

Summary for 7Y8F

Entry DOI	10.2210/pdb7y8f/pdb
Descriptor	Estrogen receptor, Grip peptide, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
Functional Keywords	complex, inhibitor, estrogen receptor alpha, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	60850.31
Authors	Min, J.,Hu, H.B.,Yang, Y.,Dong, C.E.,Zhou, H.B.,Chen, C.-C.,Guo, R.-T. (deposition date: 2022-06-23, release date: 2023-04-26, Last modification date: 2023-11-29)
Primary citation	Xin, L.,Min, J.,Hu, H.,Li, Y.,Du, C.,Xie, B.,Cheng, Y.,Deng, X.,Deng, X.,Shen, K.,Huang, J.,Chen, C.C.,Guo, R.T.,Dong, C.,Zhou, H.B. Structure-guided identification of novel dual-targeting estrogen receptor alpha degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer. Eur.J.Med.Chem., 253:115328-115328, 2023 Cited by PubMed: 37037140 DOI: 10.1016/j.ejmech.2023.115328 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.22 Å)

Structure validation