6YT2

Crystal Structure of human monoamine oxidase B in complex with Diphenylene iodonium (DPI)

Summary for 6YT2

Entry DOI	10.2210/pdb6yt2/pdb
Descriptor	Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, benzo[b][1]benziodole, ... (6 entities in total)
Functional Keywords	monoamine oxidase, drug target, neurodegeneration, ros, flavin, mitochondrial membrane, flavoprotein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	120399.65
Authors	Iacovino, L.G.,Reis, J.,Mai, A.,Mattevi, A.,Binda, C. (deposition date: 2020-04-23, release date: 2020-06-10, Last modification date: 2024-01-24)
Primary citation	Iacovino, L.G.,Reis, J.,Mai, A.,Binda, C.,Mattevi, A. Diphenylene Iodonium Is a Noncovalent MAO Inhibitor: A Biochemical and Structural Analysis. Chemmedchem, 15:1394-1397, 2020 Cited by PubMed: 32459875 DOI: 10.1002/cmdc.202000264 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation