6KSH

Crystal structure of pyruvate kinase (PYK) from Plasmodium falciparum in complex with oxalate and ATP

Summary for 6KSH

Entry DOI	10.2210/pdb6ksh/pdb
Descriptor	Pyruvate kinase, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (6 entities in total)
Functional Keywords	pyruvate kinase, glycolysis, tetramer, allostery, transferase
Biological source	Plasmodium falciparum (isolate 3D7)
Total number of polymer chains	4
Total formula weight	226663.68
Authors	Zhong, W.,Cai, Q.,Li, K.,Lescar, J.,Dedon, P.C. (deposition date: 2019-08-23, release date: 2020-08-26, Last modification date: 2023-11-22)
Primary citation	Zhong, W.,Li, K.,Cai, Q.,Guo, J.,Yuan, M.,Wong, Y.H.,Walkinshaw, M.D.,Fothergill-Gilmore, L.A.,Michels, P.A.M.,Dedon, P.C.,Lescar, J. Pyruvate kinase from Plasmodium falciparum: Structural and kinetic insights into the allosteric mechanism. Biochem.Biophys.Res.Commun., 532:370-376, 2020 Cited by PubMed: 32878705 DOI: 10.1016/j.bbrc.2020.08.048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation