8DOF
 
 | | Pseudomonas aeruginosa MurC with WYH9-2-P - OSA_001044 | | 分子名称: | (2R)-2-cyclohexyl-2-[(4-{[5-(propan-2-yl)-1H-pyrazol-3-yl]amino}-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol, 1,2-ETHANEDIOL, SULFATE ION, ... | | 著者 | Horanyi, P.S, Wang, Y, Todd, M.H, Abendroth, J, Edwards, T, Lorimer, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | 登録日 | 2022-07-13 | | 公開日 | 2022-08-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Pseudomonas aeruginosa MurC with WYH9-2-P - OSA_001044
To Be Published
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6K40
 | | Crystal structure of alkyl hydroperoxide reductase from D. radiodurans R1 | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alkyl hydroperoxide reductase AhpD, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Kim, M.-K, Zhang, J, Zhao, L. | | 登録日 | 2019-05-22 | | 公開日 | 2020-05-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Crystal structure of the AhpD-like protein DR1765 from Deinococcus radiodurans R1.
Biochem.Biophys.Res.Commun., 529, 2020
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4TZP
 | | As Grown, Untreated Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its cognate tRNAGly, and B. subtilis YbxF protein | | 分子名称: | Ribosome-associated protein L7Ae-like, engineered tRNA, glyQ T-box Stem I | | 著者 | Zhang, J, Ferre-D'Amare, A.R. | | 登録日 | 2014-07-10 | | 公開日 | 2014-09-10 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (8.503 Å) | | 主引用文献 | Dramatic Improvement of Crystals of Large RNAs by Cation Replacement and Dehydration.
Structure, 22, 2014
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6K4X
 | | Crystal structure of SMB-1 metallo-beta-lactamase in a complex with ASB | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-azanyl-2-sulfanyl-benzoic acid, Metallo-beta-lactamase, ... | | 著者 | Wachino, J. | | 登録日 | 2019-05-27 | | 公開日 | 2019-08-07 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | | 主引用文献 | 4-Amino-2-Sulfanylbenzoic Acid as a Potent Subclass B3 Metallo-beta-Lactamase-Specific Inhibitor Applicable for Distinguishing Metallo-beta-Lactamase Subclasses.
Antimicrob.Agents Chemother., 63, 2019
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6K57
 | | Crystal structure of dCas9 in complex with sgRNA and DNA (CGA PAM) | | 分子名称: | CRISPR-associated endonuclease Cas9, non-target DNA, sgRNA, ... | | 著者 | Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. | | 登録日 | 2019-05-28 | | 公開日 | 2019-09-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
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8DQK
 | | Intermediate resolution structure of barley (1,3;1,4)-beta-glucan synthase CslF6. | | 分子名称: | Cellulose synthase-like CslF6 | | 著者 | Ho, R, Purushotham, P, Zimmer, J. | | 登録日 | 2022-07-19 | | 公開日 | 2022-11-30 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Mechanism of mixed-linkage glucan biosynthesis by barley cellulose synthase-like CslF6 (1,3;1,4)-beta-glucan synthase.
Sci Adv, 8, 2022
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6KG2
 | | Human MTHFD2 in complex with Compound 18 | | 分子名称: | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, N-[2-chloranyl-4-[[7-methyl-8-(4-methylpiperazin-1-yl)-5-oxidanylidene-2,4-dihydro-1H-chromeno[3,4-c]pyridin-3-yl]carbonyl]phenyl]methanesulfonamide, ... | | 著者 | Suzuki, M, Matsui, Y, Ota, M, Kawai, J. | | 登録日 | 2019-07-10 | | 公開日 | 2019-11-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity.
J.Med.Chem., 62, 2019
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6KJW
 | | Galectin-13 variant C136S | | 分子名称: | Galactoside-binding soluble lectin 13 | | 著者 | Su, J. | | 登録日 | 2019-07-23 | | 公開日 | 2019-10-16 | | 最終更新日 | 2020-02-19 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution.
Glycobiology, 30, 2020
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8DMO
 | | Structure of open, inward-facing MsbA from E. coli | | 分子名称: | ATP-binding transport protein MsbA | | 著者 | Liu, C, Lyu, J, Laganowsky, A.D, Zhao, M. | | 登録日 | 2022-07-08 | | 公開日 | 2022-12-14 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural basis for lipid and copper regulation of the ABC transporter MsbA.
Nat Commun, 13, 2022
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8EFK
 | | Structure of Lates calcarifer DNA polymerase theta polymerase domain with hairpin DNA | | 分子名称: | 2',3'-dideoxyadenosine triphosphate, DNA (5'-D(P*TP*TP*TP*TP*GP*GP*CP*TP*TP*TP*TP*GP*CP*CP*(2DA))-3'), Lates calcarifer DNA polymerase theta, ... | | 著者 | Li, C, Zhu, H, Sun, J, Gao, Y. | | 登録日 | 2022-09-08 | | 公開日 | 2022-12-14 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis of DNA polymerase theta mediated DNA end joining.
Nucleic Acids Res., 51, 2023
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6KF3
 | | Cryo-EM structure of Thermococcus kodakarensis RNA polymerase | | 分子名称: | DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit A'', DNA-directed RNA polymerase subunit D, ... | | 著者 | Jun, S.-H, Hyun, J, Jeong, H, Cha, J.S, Kim, H, Bartlett, M.S, Cho, H.-S, Murakami, K.S. | | 登録日 | 2019-07-06 | | 公開日 | 2020-07-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Direct binding of TFE alpha opens DNA binding cleft of RNA polymerase.
Nat Commun, 11, 2020
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8EF9
 | | Structure of Lates calcarifer DNA polymerase theta polymerase domain with long duplex DNA, complex Ia | | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*AP*TP*CP*CP*GP*TP*AP*GP*(2DA))-3'), DNA (5'-D(*AP*GP*CP*TP*CP*TP*AP*CP*GP*GP*AP*TP*GP*C)-3'), ... | | 著者 | Li, C, Zhu, H, Sun, J, Gao, Y. | | 登録日 | 2022-09-08 | | 公開日 | 2022-12-14 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | Structural basis of DNA polymerase theta mediated DNA end joining.
Nucleic Acids Res., 51, 2023
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8DW2
 | | Cryo-EM structure of SARS-CoV-2 RBD in complex with anti-SARS-CoV-2 DARPin,SR22, and two antibody Fabs, S309 and CR3022 | | 分子名称: | Antibody CR3022 heavy chain, Antibody CR3022 light chain, Antibody S309 heavy chain, ... | | 著者 | Kwon, Y.D, Gorman, J, Kwong, P.D. | | 登録日 | 2022-07-30 | | 公開日 | 2022-12-07 | | 最終更新日 | 2023-03-15 | | 実験手法 | ELECTRON MICROSCOPY (4.11 Å) | | 主引用文献 | A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins.
Nat.Chem.Biol., 19, 2023
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6KIU
 | | Cryo-EM structure of human MLL1-ubNCP complex (3.2 angstrom) | | 分子名称: | DNA (145-MER), GLUTAMINE, Histone H2A, ... | | 著者 | Huang, J, Xue, H, Yao, T. | | 登録日 | 2019-07-20 | | 公開日 | 2019-09-11 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
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6KJB
 | | wild-type apo-form E. coli ATCase holoenzyme with an unusual open conformation of R167 | | 分子名称: | Aspartate carbamoyltransferase catalytic subunit, Aspartate carbamoyltransferase regulatory chain, ZINC ION | | 著者 | Wang, N, Lei, Z, Zheng, J, Jia, Z.C. | | 登録日 | 2019-07-22 | | 公開日 | 2020-06-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Conformational Plasticity of the Active Site Entrance inE. coliAspartate Transcarbamoylase and Its Implication in Feedback Regulation.
Int J Mol Sci, 21, 2020
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8DW3
 | | Cryo-EM structure of SARS-CoV-2 RBD in complex with anti-SARS-CoV-2 DARPin,SR16m, and two antibody Fabs, S309 and CR3022 | | 分子名称: | Anti-SARS-CoV-2 DARPin SR16m, Antibody S309 light chain, Spike protein S1, ... | | 著者 | Kwon, Y.D, Gorman, J, Kwong, P.D. | | 登録日 | 2022-07-30 | | 公開日 | 2022-12-07 | | 最終更新日 | 2023-03-15 | | 実験手法 | ELECTRON MICROSCOPY (4.26 Å) | | 主引用文献 | A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins.
Nat.Chem.Biol., 19, 2023
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6KN0
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8EFC
 | | Structure of Lates calcarifer DNA polymerase theta polymerase domain with long duplex DNA, complex Ia | | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*CP*TP*GP*TP*GP*AP*GP*GP*CP*AP*TP*CP*CP*GP*TP*AP*GP*(2DA))-3'), DNA (5'-D(*AP*GP*CP*TP*CP*TP*AP*CP*GP*GP*AP*TP*GP*CP*CP*TP*CP*AP*CP*AP*G)-3'), ... | | 著者 | Li, C, Zhu, H, Sun, J, Gao, Y. | | 登録日 | 2022-09-08 | | 公開日 | 2022-12-14 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural basis of DNA polymerase theta mediated DNA end joining.
Nucleic Acids Res., 51, 2023
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8E6Y
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6JT8
 | | Crystal structure of 450-451_deletion mutant of FGAM Synthetase | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | | 著者 | Sharma, N, Ahalawat, N, Sandhu, P, Mondal, J, Anand, R. | | 登録日 | 2019-04-10 | | 公開日 | 2020-03-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation.
Sci Adv, 6, 2020
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6K43
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6K54
 | | Hyperthermophilic GH6 cellobiohydrolase II (HmCel6A) in complex with trisaccharide | | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Baba, S, Takeda, M, Okuma, J, Hirose, Y, Nishimura, A, Takata, M, Oda, K, Shibata, D, Kondo, Y, Kumasaka, T. | | 登録日 | 2019-05-28 | | 公開日 | 2020-06-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.905 Å) | | 主引用文献 | Novel hyperthermophilic cellobiohydrolase II isolated from hot spring microbial community
To Be Published
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8EDJ
 | | Crystal structure of rA3G-ssRNA-GA | | 分子名称: | DNA dC->dU-editing enzyme APOBEC-3G, RNA (5'-R(P*UP*GP*AP*UP*UP*U)-3'), SULFATE ION, ... | | 著者 | Pacheco, J, Yang, H.J, Li, S.-X, Chen, X.S. | | 登録日 | 2022-09-04 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G.
Nat Commun, 13, 2022
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6K61
 | | Cryo-EM structure of the tetrameric photosystem I from a heterocyst-forming cyanobacterium Anabaena sp. PCC7120 | | 分子名称: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | | 著者 | Zheng, L, Li, Y, Li, X, Zhong, Q, Li, N, Zhang, K, Zhang, Y, Chu, H, Ma, C, Li, G, Zhao, J, Gao, N. | | 登録日 | 2019-05-31 | | 公開日 | 2019-10-09 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.37 Å) | | 主引用文献 | Structural and functional insights into the tetrameric photosystem I from heterocyst-forming cyanobacteria.
Nat.Plants, 5, 2019
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8E3I
 | | CRYO-EM STRUCTURE OF the human MPSF IN COMPLEX WITH THE AUUAAA poly(A) signal | | 分子名称: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, RNA (5'-R(P*CP*AP*UP*UP*AP*AP*AP*CP*AP*AP*C)-3'), ... | | 著者 | Gutierrez, P.A, Wei, J, Sun, Y, Tong, L. | | 登録日 | 2022-08-17 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.53 Å) | | 主引用文献 | Molecular basis for the recognition of the AUUAAA polyadenylation signal by mPSF.
Rna, 28, 2022
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