5VYA
 
 | | S. cerevisiae Hsp104:casein complex, Extended Conformation | | 分子名称: | Alpha-S1-casein, Heat shock protein 104, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | 著者 | Gates, S.N, Yokom, A.L, Lin, J.-B, Jackrel, M.E, Rizo, A.N, Kendsersky, N.M, Buell, C.E, Sweeny, E.A, Chuang, E, Torrente, M.P, Mack, K.L, Su, M, Shorter, J, Southworth, D.R. | | 登録日 | 2017-05-24 | | 公開日 | 2017-07-05 | | 最終更新日 | 2017-08-02 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.
Science, 357, 2017
|
|
7R47
 | | Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine, ... | | 著者 | Bridges, H.R, Blaza, J.N, Yin, Z, Chung, I, Hirst, J. | | 登録日 | 2022-02-08 | | 公開日 | 2023-02-08 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides.
Science, 379, 2023
|
|
7VFP
 | | Cytochrome c-type biogenesis protein CcmABCD from E. coli in complex with heme and single ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein B, ... | | 著者 | Li, J, Zheng, W, Gu, M, Zhang, K, Zhu, J.P. | | 登録日 | 2021-09-13 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.03 Å) | | 主引用文献 | Structures of the CcmABCD heme release complex at multiple states.
Nat Commun, 13, 2022
|
|
7R4C
 | | Bovine complex I in the presence of IM1761092, deactive class v (Composite map) | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine, ... | | 著者 | Bridges, H.R, Blaza, J.N, Yin, Z, Chung, I, Hirst, J. | | 登録日 | 2022-02-08 | | 公開日 | 2023-02-08 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides.
Science, 379, 2023
|
|
5KEL
 | | EBOV GP in complex with variable Fab domains of IgGs c2G4 and c13C6 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ebola surface glycoprotein, ... | | 著者 | Pallesen, J, Murin, C.D, de Val, N, Cottrell, C.A, Hastie, K.M, Turner, H.L, Fusco, M.L, Flyak, A.I, Zeitlin, L, Crowe Jr, J.E, Andersen, K.G, Saphire, E.O, Ward, A.B. | | 登録日 | 2016-06-09 | | 公開日 | 2016-09-07 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
|
|
8UCR
 | |
2HW5
 | | The crystal structure of human enoyl-coenzyme A (CoA) hydratase short chain 1, ECHS1 | | 分子名称: | CROTONYL COENZYME A, Enoyl-CoA hydratase, MAGNESIUM ION | | 著者 | Turnbull, A.P, Salah, E, Niesen, F, Debreczeni, J, Ugochukwu, E, Pike, A.C.W, Kavanagh, K, Gileadi, O, Gorrec, F, Umeano, C, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC) | | 登録日 | 2006-07-31 | | 公開日 | 2006-08-22 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | The crystal structure of human enoyl-coenzyme A (CoA) hydratase short chain 1, ECHS1
To be Published
|
|
7V48
 | |
7V47
 | |
5KHM
 | | The first BET bromodomain of BRD4 bound to compound 13 in a bivalent manner | | 分子名称: | (3~{R})-4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one, Bromodomain-containing protein 4, GLYCEROL | | 著者 | Patel, J. | | 登録日 | 2016-06-15 | | 公開日 | 2016-09-21 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153).
J.Med.Chem., 59, 2016
|
|
6GNO
 | | Crystal Structure Of Sea Bream Transthyretin in complex with Tetrabromobisphenol A (TBBPA) | | 分子名称: | 4,4'-propane-2,2-diylbis(2,6-dibromophenol), SULFATE ION, Transthyretin | | 著者 | Grundstrom, C, Zhang, J, Olofsson, A, Andersson, P.L, Sauer-Eriksson, A.E. | | 登録日 | 2018-05-31 | | 公開日 | 2018-07-11 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Interspecies Variation between Fish and Human Transthyretins in Their Binding of Thyroid-Disrupting Chemicals.
Environ. Sci. Technol., 52, 2018
|
|
8UO6
 | |
5KGM
 | | 2.95A resolution structure of Apo independent phosphoglycerate mutase from C. elegans (monoclinic form) | | 分子名称: | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, CHLORIDE ION, MANGANESE (II) ION, ... | | 著者 | Lovell, S, Mehzabeen, N, Battaile, K.P, Yu, H, Dranchak, P, MacArthur, R, Li, Z, Carlow, T, Suga, H, Inglese, J. | | 登録日 | 2016-06-13 | | 公開日 | 2017-04-05 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases.
Nat Commun, 8, 2017
|
|
8BZN
 | | SARS-CoV-2 non-structural protein 10 (nsp10) variant T102I | | 分子名称: | CHLORIDE ION, DIMETHYL SULFOXIDE, Replicase polyprotein 1ab, ... | | 著者 | Wang, H, Rizvi, S.R.A, Dong, D, Lou, J, Wang, Q, Sopipong, W, Najar, F, Agarwal, P.K, Kozielski, F, Haider, S. | | 登録日 | 2022-12-15 | | 公開日 | 2023-12-27 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16.
Elife, 12, 2023
|
|
5LLU
 | | Structure of the thermostabilized EAAT1 cryst-II mutant in complex with L-ASP | | 分子名称: | ASPARTIC ACID, Excitatory amino acid transporter 1,Neutral amino acid transporter B(0),Excitatory amino acid transporter 1, SODIUM ION | | 著者 | Canul-Tec, J, Assal, R, Legrand, P, Reyes, N. | | 登録日 | 2016-07-28 | | 公開日 | 2017-04-19 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.32 Å) | | 主引用文献 | Structure and allosteric inhibition of excitatory amino acid transporter 1.
Nature, 544, 2017
|
|
2HUP
 | | Crystal structure of human RAB43 in complex with GDP | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAS-related protein RAB-43, ... | | 著者 | Wang, J, Shen, Y, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | | 登録日 | 2006-07-27 | | 公開日 | 2006-08-08 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Crystal structure of human RAB43 in complex with GDP
To be Published
|
|
5KH6
 | | SETDB1 in complex with a fragment candidate | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | | 著者 | Walker, J.R, Harding, R.J, Mader, P, Dobrovetsky, E, Dong, A, Collins, P, Pearce, N, Brandao-Neto, J, Douangamath, A, von Delft, F, Brown, P.J, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Santhakumar, V, Structural Genomics Consortium (SGC) | | 登録日 | 2016-06-14 | | 公開日 | 2016-09-21 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | SETDB1 in complex with a fragment candidate
To be published
|
|
3T11
 | | Dimeric inhibitor of HIV-1 protease. | | 分子名称: | (3S,11S)-11-(3-chloro-4-hydroxy-5-methoxyphenyl)-3-phenyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... | | 著者 | Brynda, J, Rezacova, P, Saskova, G.K, Kozisek, M, Konvalinka, J. | | 登録日 | 2011-07-21 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Dimeric inhibitor of HIV-1 protease.
To be Published
|
|
8UEJ
 | | ssRNA phage PhiCb5 virion | | 分子名称: | CALCIUM ION, Coat protein, Maturation protein | | 著者 | Wang, Y, Zhang, J. | | 登録日 | 2023-10-01 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural mechanisms of Tad pilus assembly and its interaction with an RNA virus.
Sci Adv, 10, 2024
|
|
8BYX
 | |
5YGH
 | | Crystal Structure of the Capsid Protein from Zika Virus | | 分子名称: | Capsid protein | | 著者 | Shang, Z, Song, H, Shi, Y, Qi, J, Gao, G.F. | | 登録日 | 2017-09-23 | | 公開日 | 2018-02-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.884 Å) | | 主引用文献 | Crystal Structure of the Capsid Protein from Zika Virus.
J. Mol. Biol., 430, 2018
|
|
5YH2
 | |
8UW6
 | | Acetylornithine deacetylase from Escherichia coli, di-zinc form. | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Acetylornithine deacetylase, ... | | 著者 | Osipiuk, J, Endres, M, Kelley, E, Becker, D.P, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID) | | 登録日 | 2023-11-06 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | N alpha-acetyl-L-ornithine deacetylase from Escherichia coli and a ninhydrin-based assay to enable inhibitor identification.
Front Chem, 12, 2024
|
|
5KDD
 | | Apo-structure of humanised RadA-mutant humRadA22 | | 分子名称: | DNA repair and recombination protein RadA, SULFATE ION | | 著者 | Fischer, G, Marsh, M, Moschetti, T, Sharpe, T, Scott, D, Morgan, M, Ng, H, Skidmore, J, Venkitaraman, A, Abell, C, Blundell, T.L, Hyvonen, M. | | 登録日 | 2016-06-08 | | 公開日 | 2016-10-19 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
|
|
8BZM
 | | FOXK1-ELF1-heterodimer bound to DNA | | 分子名称: | DNA, ETS-related transcription factor Elf-1, Forkhead box protein K1, ... | | 著者 | Morgunova, E, Popov, A, Yin, Y, Taipale, J. | | 登録日 | 2022-12-15 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | FOXK1-ELF1_heterodimer bound to DNA
To Be Published
|
|
