5HE2
| Bovine GRK2 in complex with Gbetagamma subunits and CCG224406 | 分子名称: | (4~{S})-4-[3-[(2,6-dimethoxyphenyl)methylcarbamoyl]-4-fluoranyl-phenyl]-~{N}-(1~{H}-indazol-5-yl)-6-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-pyrimidine-5-carboxamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Cato, M.C, Waninger-Saroni, J, Tesmer, J.J.G. | 登録日 | 2016-01-05 | 公開日 | 2016-05-11 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J.Med.Chem., 59, 2016
|
|
7KGB
| |
6NJA
| Structure of WT RET protein tyrosine kinase domain at 1.92A resolution. | 分子名称: | ADENINE, FORMIC ACID, Proto-oncogene tyrosine-protein kinase receptor Ret | 著者 | Terzyan, S.S, Shen, T, Wu, J, Mooers, B.H.M. | 登録日 | 2019-01-02 | 公開日 | 2019-06-05 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J.Biol.Chem., 294, 2019
|
|
2CN1
| Crystal structure of Human Cytosolic 5'-Nucleotidase III (NT5C3) | 分子名称: | CYTOSOLIC 5'-NUCLEOTIDASE III | 著者 | Wallden, K, Stenmark, P, Arrowsmith, C, Berglund, H, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg Schiavone, L, Hogbom, M, Kotenyova, T, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Thorsell, A.G, Uppenberg, J, Van Den Berg, S, Weigelt, J, Welin, M, Nordlund, P. | 登録日 | 2006-05-17 | 公開日 | 2006-06-12 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | 主引用文献 | Crystal Structure of Human Cytosolic 5'-Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition. J.Biol.Chem., 282, 2007
|
|
1T4J
| Allosteric Inhibition of Protein Tyrosine Phosphatase 1B | 分子名称: | 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID [4-(THIAZOL-2-YLSULFAMOYL)-PHENYL]-AMIDE, Protein-tyrosine phosphatase, non-receptor type 1 | 著者 | Wiesmann, C, Barr, K.J, Kung, J, Zhu, J, Shen, W, Fahr, B.J, Zhong, M, Taylor, L, Randal, M, McDowell, R.S, Hansen, S.K. | 登録日 | 2004-04-29 | 公開日 | 2004-07-20 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Allosteric inhibition of protein tyrosine phosphatase 1B Nat.Struct.Mol.Biol., 11, 2004
|
|
7XVI
| |
7XVK
| |
6H8B
| Molybdenum storage protein prepared under in vivo-like conditions and incubated with ATP and molybdate at 303 K | 分子名称: | 2,2,4-tris(oxidanyl)-1,3-dioxa-2$l^{4},4$l^{3}-dimolybdacyclobutane, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Ermler, U, Poppe, J. | 登録日 | 2018-08-02 | 公開日 | 2019-02-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The molybdenum storage protein - A bionanolab for creating experimentally alterable polyoxomolybdate clusters. J. Inorg. Biochem., 189, 2018
|
|
5ZMB
| |
1XEF
| Crystal structure of the ATP/Mg2+ bound composite dimer of HlyB-NBD | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Alpha-hemolysin translocation ATP-binding protein hlyB, MAGNESIUM ION | 著者 | Zaitseva, J, Jenewein, S, Holland, I.B, Schmitt, L. | 登録日 | 2004-09-10 | 公開日 | 2005-06-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | H662 is the linchpin of ATP hydrolysis in the nucleotide-binding domain of the ABC transporter HlyB Embo J., 24, 2005
|
|
1XFY
| Crystal structure of anthrax edema factor (EF) in complex with calmodulin | 分子名称: | CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ... | 著者 | Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J. | 登録日 | 2004-09-15 | 公開日 | 2005-05-03 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J., 24, 2005
|
|
6ILT
| Structure of Arabidopsis thaliana Ribokinase complexed with ATP and Magnesium ion | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ribokinase, ... | 著者 | Kang, P, Oh, J, Rhee, S. | 登録日 | 2018-10-19 | 公開日 | 2019-03-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure and mutational analyses of ribokinase from Arabidopsis thaliana. J. Struct. Biol., 206, 2019
|
|
5KK3
| Atomic Resolution Structure of Monomorphic AB42 Amyloid Fibrils | 分子名称: | Beta-amyloid protein 42 | 著者 | Colvin, M.T, Silvers, R, Zhe Ni, Q, Can, T.V, Sergeyev, I, Rosay, M, Donovan, K.J, Michael, B, Wall, J, Linse, S, Griffin, R.G. | 登録日 | 2016-06-20 | 公開日 | 2016-07-13 | 最終更新日 | 2024-05-01 | 実験手法 | SOLID-STATE NMR | 主引用文献 | Atomic Resolution Structure of Monomorphic A beta 42 Amyloid Fibrils. J.Am.Chem.Soc., 138, 2016
|
|
4RPF
| Crystal structure of homoserine kinase from Yersinia pestis Nepal516, NYSGRC target 032715 | 分子名称: | CITRIC ACID, Homoserine kinase | 著者 | Ptskovsky, Y, Bhosle, R, Toro, R, Hillerich, B, Gizzi, A, Garforth, S, Kar, A, Chan, M.K, Lafluer, J, Patel, H, Matikainen, B, Chamala, S, Lim, S, Celikgil, A, Villegas, G, Evans, B, Love, J, Fiser, A, Seidel, R, Bonanno, J.B, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) | 登録日 | 2014-10-30 | 公開日 | 2014-11-12 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure of Homoserine Kinase from Yersinia Pestis Nepal516, Nysgrc Target 032715 To be Published
|
|
5HWJ
| Crystal structure of keto-deoxy-D-galactarate dehydratase | 分子名称: | FORMIC ACID, GLYCEROL, Probable 5-dehydro-4-deoxyglucarate dehydratase | 著者 | Taberman, H, Parkkinen, T, Hakulinen, N, Rouvinen, J. | 登録日 | 2016-01-29 | 公開日 | 2016-03-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.648 Å) | 主引用文献 | Structure and function of a decarboxylating Agrobacterium tumefaciens keto-deoxy-d-galactarate dehydratase. Biochemistry, 53, 2014
|
|
5HXI
| |
3L8N
| Crystal Structure of a domain of Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BrefeldinA-inhibited GEP 2) from Homo sapiens (Human). Northeast Structural Genomics Consortium target id HR5562A | 分子名称: | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 | 著者 | Seetharaman, J, Su, M, Forouhar, F, Wang, D, Janjua, H, Cunningham, K, Owens, L, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2009-12-31 | 公開日 | 2010-04-07 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Crystal Structure of a domain of Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BrefeldinA-inhibited GEP 2) from Homo sapiens (Human). Northeast Structural Genomics Consortium target id HR5562A To be Published
|
|
4RJZ
| Crystal structure of ATU4361 sugar transporter from Agrobacterium fabrum C58, target EFI-510558, an open conformation | 分子名称: | ABC transporter, substrate binding protein (Sugar), CHLORIDE ION, ... | 著者 | Patskovsky, Y, Toro, R, Bhosle, R, Al Obaidi, N, Chamala, S, Attonito, J.D, Scott Glenn, A, Chowdhury, S, Lafleur, J, Siedel, R.D, Hillerich, B, Love, J, Whalen, K.L, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | 登録日 | 2014-10-11 | 公開日 | 2014-11-05 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | 主引用文献 | Crystal Structure of Maltoside Transporter ATU4361 from Agrobacterium Fabrum, Target EFI-510558 To be Published
|
|
5H99
| |
2HZB
| X-Ray Crystal Structure of Protein BH3568 from Bacillus halodurans. Northeast Structural Genomics Consortium BhR60. | 分子名称: | Hypothetical UPF0052 protein BH3568 | 著者 | Kuzin, A.P, Chen, Y, Seetharaman, J, Benach, J, Shastry, R, Conover, K, Ma, L.C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2006-08-08 | 公開日 | 2006-08-22 | 最終更新日 | 2017-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | X-Ray structure of the hypothetical UPF0052 protein BH3568 from Bacillus halodurans. Northeast Structural Genomics Consortium BhR60. To be Published
|
|
2ES3
| |
5H9I
| Crystal structure of Geobacter metallireducens SMUG1 with xanthine | 分子名称: | BETA-MERCAPTOETHANOL, GLYCEROL, Geobacter metallireducens SMUG1, ... | 著者 | Xie, W, Cao, W, Zhang, Z, Shen, J. | 登録日 | 2015-12-28 | 公開日 | 2016-04-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | 主引用文献 | Structural Basis of Substrate Specificity in Geobacter metallireducens SMUG1 Acs Chem.Biol., 11, 2016
|
|
7XW5
| TSHR-thyroid stimulating hormone-Gs-ML109 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, Glycoprotein hormones alpha chain, ... | 著者 | Duan, J, Xu, P, Luan, X, Ji, Y, Yuan, Q, He, X, Ye, J, Cheng, X, Jiang, H, Zhang, S, Jiang, Y, Xu, H.E. | 登録日 | 2022-05-26 | 公開日 | 2022-08-24 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Hormone- and antibody-mediated activation of the thyrotropin receptor. Nature, 609, 2022
|
|
6MIB
| |
4QG0
| Crystal structure of the tetrameric dGTP/dUTP-bound SAMHD1 (RN206) mutant catalytic core | 分子名称: | 1,2-ETHANEDIOL, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DEOXYURIDINE-5'-TRIPHOSPHATE, ... | 著者 | Koharudin, L.M.I, Wu, Y, DeLucia, M, Mehrens, J, Gronenborn, A.M, Ahn, J. | 登録日 | 2014-05-22 | 公開日 | 2014-10-15 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Basis of Allosteric Activation of Sterile alpha Motif and Histidine-Aspartate Domain-containing Protein 1 (SAMHD1) by Nucleoside Triphosphates. J.Biol.Chem., 289, 2014
|
|