7KGB

CryoEM structure of A2296-methylated Mycobacterium tuberculosis ribosome bound with SEQ-9

This is a non-PDB format compatible entry.

Summary for 7KGB

• Entry DOI: 10.2210/pdb7kgb/pdb
• EMDB information: 22865
• Descriptor: 50S ribosomal protein L32, 50S ribosomal protein L3, 50S ribosomal protein L4, ... (55 entities in total)
• Functional Keywords: antibiotic, methylation, pathogen, ribosome, ribosome-antibiotic complex, ribosome/antibiotic
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); More
• Total number of polymer chains: 52
• Total formula weight: 2272100.28

Authors

Cui, Z.,Zhang, J. (deposition date: 2020-10-16, release date: 2022-01-19, Last modification date: 2024-05-29)

• Primary citation: Zhang, J.,Lair, C.,Roubert, C.,Amaning, K.,Barrio, M.B.,Benedetti, Y.,Cui, Z.,Xing, Z.,Li, X.,Franzblau, S.G.,Baurin, N.,Bordon-Pallier, F.,Cantalloube, C.,Sans, S.,Silve, S.,Blanc, I.,Fraisse, L.,Rak, A.,Jenner, L.B.,Yusupova, G.,Yusupov, M.,Zhang, J.,Kaneko, T.,Yang, T.J.,Fotouhi, N.,Nuermberger, E.,Tyagi, S.,Betoudji, F.,Upton, A.,Sacchettini, J.C.,Lagrange, S.; Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.; Cell, 2023; PubMed: 36827973; DOI: 10.1016/j.cell.2023.01.043

Experimental method

ELECTRON MICROSCOPY (2.7 Å)