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PDB: 42391 件
8VW4
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Crystal structure of Cbl-b TKB bound to compound 26
分子名称: (7-methoxy-2-{2-[(1S,3S,4S)-3-(3-methoxy-2-methyl-5-nitrophenyl)-1-methyl-5-oxo-1,5-dihydroimidazo[1,5-a]pyridin-2(3H)-yl]-2-oxoethoxy}quinolin-8-yl)acetic acid, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase CBL-B, ...
著者Yu, C, Murray, J, Hsu, P.L.
登録日2024-01-31
公開日2024-07-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding.
Acs Med.Chem.Lett., 15, 2024
7P6S
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BU of 7p6s by Molmil
Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form II)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform Alpha of Pancreatic secretory granule membrane major glycoprotein GP2, pentane-1,5-diol
著者Stsiapanava, A, Tunyasuvunakool, K, Jumper, J, de Sanctis, D, Jovine, L.
登録日2021-07-17
公開日2022-03-16
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.
Nat.Struct.Mol.Biol., 29, 2022
7P6T
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Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form III)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-ethyl-2-(hydroxymethyl)propane-1,3-diol, Isoform Alpha of Pancreatic secretory granule membrane major glycoprotein GP2
著者Stsiapanava, A, Tunyasuvunakool, K, Jumper, J, de Sanctis, D, Jovine, L.
登録日2021-07-17
公開日2022-03-16
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.
Nat.Struct.Mol.Biol., 29, 2022
7P6R
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BU of 7p6r by Molmil
Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form I)
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform Alpha of Pancreatic secretory granule membrane major glycoprotein GP2
著者Stsiapanava, A, Tunyasuvunakool, K, Jumper, J, de Sanctis, D, Jovine, L.
登録日2021-07-17
公開日2022-03-16
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.
Nat.Struct.Mol.Biol., 29, 2022
8T4M
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BU of 8t4m by Molmil
Closed human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
著者Burtscher, V, Mount, J, Cowgill, J, Chang, Y, Bickel, K, Yuan, P, Chanda, B.
登録日2023-06-09
公開日2024-06-12
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.16 Å)
主引用文献Structural basis for hyperpolarization-dependent opening of human HCN1 channel.
Nat Commun, 15, 2024
8BWT
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BU of 8bwt by Molmil
Structure of a symmetrical internal loop motif with three consecutive U:U mismatches from stem-loop 1 in the 3'-UTR of the SARS-CoV2 genomic RNA
分子名称: RNA (26-MER)
著者Voegele, J, Duchardt-Ferner, E, Schwalbe, H, Woehnert, J.
登録日2022-12-07
公開日2023-08-30
最終更新日2024-07-03
実験手法SOLUTION NMR
主引用文献Structure of an internal loop motif with three consecutive U•U mismatches from stem-loop 1 in the 3'-UTR of the SARS-CoV-2 genomic RNA.
Nucleic Acids Res., 52, 2024
115D
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BU of 115d by Molmil
ORDERED WATER STRUCTURE IN AN A-DNA OCTAMER AT 1.7 ANGSTROMS RESOLUTION
分子名称: DNA (5'-D(*GP*GP*(BRU)P*AP*(BRU)P*AP*CP*C)-3')
著者Kennard, O, Cruse, W.B.T, Nachman, J, Prange, T, Shakked, Z, Rabinovich, D.
登録日1993-02-12
公開日1993-07-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Ordered water structure in an A-DNA octamer at 1.7 A resolution.
J.Biomol.Struct.Dyn., 3, 1986
11AS
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BU of 11as by Molmil
ASPARAGINE SYNTHETASE MUTANT C51A, C315A COMPLEXED WITH L-ASPARAGINE
分子名称: ASPARAGINE, ASPARAGINE SYNTHETASE
著者Nakatsu, T, Kato, H, Oda, J.
登録日1997-12-02
公開日1998-12-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of asparagine synthetase reveals a close evolutionary relationship to class II aminoacyl-tRNA synthetase.
Nat.Struct.Biol., 5, 1998
1A38
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BU of 1a38 by Molmil
14-3-3 PROTEIN ZETA BOUND TO R18 PEPTIDE
分子名称: 14-3-3 PROTEIN ZETA, R18 PEPTIDE (PHCVPRDLSWLDLEANMCLP)
著者Petosa, C, Masters, S.C, Pohl, J, Wang, B, Fu, H, Liddington, R.C.
登録日1998-01-28
公開日1999-03-02
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove.
J.Biol.Chem., 273, 1998
1ANR
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BU of 1anr by Molmil
CIS-ACTING RNA REGULATORY ELEMENT (HIV-1 TAR), NMR, 20 STRUCTURES
分子名称: RNA REGULATORY ELEMENT TAR
著者Aboul-Ela, F, Varani, G, Karn, J.
登録日1996-07-06
公開日1997-01-11
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of HIV-1 TAR RNA in the absence of ligands reveals a novel conformation of the trinucleotide bulge.
Nucleic Acids Res., 24, 1996
156D
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BU of 156d by Molmil
REFINED SOLUTION STRUCTURE OF THE DIMERIC QUADRUPLEX FORMED FROM THE OXYTRICHA TELOMERIC OLIGONUCLEOTIDE D(GGGGTTTTGGGG)
分子名称: DNA (5'-D(*GP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3')
著者Schultze, P, Smith, F.W, Feigon, J.
登録日1994-01-17
公開日1994-04-30
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Refined solution structure of the dimeric quadruplex formed from the Oxytricha telomeric oligonucleotide d(GGGGTTTTGGGG).
Structure, 2, 1994
199L
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BU of 199l by Molmil
THERMODYNAMIC AND STRUCTURAL COMPENSATION IN "SIZE-SWITCH" CORE-REPACKING VARIANTS OF T4 LYSOZYME
分子名称: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
著者Baldwin, E, Xu, J, Hajiseyedjavadi, O, Matthews, B.W.
登録日1995-11-06
公開日1996-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Thermodynamic and structural compensation in "size-switch" core repacking variants of bacteriophage T4 lysozyme.
J.Mol.Biol., 259, 1996
1AKP
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BU of 1akp by Molmil
SEQUENTIAL 1H,13C AND 15N NMR ASSIGNMENTS AND SOLUTION CONFORMATION OF APOKEDARCIDIN
分子名称: APOKEDARCIDIN
著者Constantine, K.L, Colson, K.L, Wittekind, M, Friedrichs, M.S, Zein, N, Tuttle, J, Langley, D.R, Leet, J.E, Schroeder, D.R, Lam, K.S, Farmer II, B.T, Metzler, W.J, Bruccoleri, R.E, Mueller, L.
登録日1994-06-20
公開日1994-08-31
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Sequential 1H, 13C, and 15N NMR assignments and solution conformation of apokedarcidin.
Biochemistry, 33, 1994
195L
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BU of 195l by Molmil
THERMODYNAMIC AND STRUCTURAL COMPENSATION IN "SIZE-SWITCH" CORE-REPACKING VARIANTS OF T4 LYSOZYME
分子名称: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
著者Baldwin, E, Xu, J, Hajiseyedjavadi, O, Matthews, B.W.
登録日1995-11-06
公開日1996-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Thermodynamic and structural compensation in "size-switch" core repacking variants of bacteriophage T4 lysozyme.
J.Mol.Biol., 259, 1996
8T12
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BU of 8t12 by Molmil
Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 ordered.
分子名称: Non-structural protein 5, Signal transducer and activator of transcription 2, ZINC ION
著者Biswal, M, Lu, J, Song, J.
登録日2023-06-01
公開日2024-01-17
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (3.34 Å)
主引用文献A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition.
Commun Biol, 7, 2024
8T13
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BU of 8t13 by Molmil
Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 disordered
分子名称: Non-structural protein 5, Signal transducer and activator of transcription 2, ZINC ION
著者Biswal, M, Lu, J, Song, J.
登録日2023-06-01
公開日2024-01-17
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (3.45 Å)
主引用文献A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition.
Commun Biol, 7, 2024
7PFP
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BU of 7pfp by Molmil
Full-length cryo-EM structure of the native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Jovine, L, Xu, C, Stsiapanava, A, Carroni, M, Tunyasuvunakool, K, Jumper, J, Wu, B.
登録日2021-08-11
公開日2022-03-16
最終更新日2022-03-30
実験手法ELECTRON MICROSCOPY (6.1 Å)
主引用文献Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.
Nat.Struct.Mol.Biol., 29, 2022
1AIB
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BU of 1aib by Molmil
STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING THE PYRIDOXAL-5'-PHOSPHATE BINDING LYSINE RESIDUE
分子名称: 2-OXOGLUTARIC ACID, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, ASPARTATE AMINOTRANSFERASE
著者Jaeger, J, Jansonius, J.N.
登録日1994-05-10
公開日1994-10-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking the pyridoxal 5'-phosphate-binding lysine residue.
Biochemistry, 34, 1995
196L
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BU of 196l by Molmil
THERMODYNAMIC AND STRUCTURAL COMPENSATION IN "SIZE-SWITCH" CORE-REPACKING VARIANTS OF T4 LYSOZYME
分子名称: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
著者Baldwin, E, Xu, J, Hajiseyedjavadi, O, Matthews, B.W.
登録日1995-11-06
公開日1996-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Thermodynamic and structural compensation in "size-switch" core repacking variants of bacteriophage T4 lysozyme.
J.Mol.Biol., 259, 1996
198L
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BU of 198l by Molmil
THERMODYNAMIC AND STRUCTURAL COMPENSATION IN "SIZE-SWITCH" CORE-REPACKING VARIANTS OF T4 LYSOZYME
分子名称: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
著者Baldwin, E, Xu, J, Hajiseyedjavadi, O, Matthews, B.W.
登録日1995-11-06
公開日1996-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Thermodynamic and structural compensation in "size-switch" core repacking variants of bacteriophage T4 lysozyme.
J.Mol.Biol., 259, 1996
8CGO
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BU of 8cgo by Molmil
Structure of human butyrylcholinesterase in complex with N-{[2-(benzyloxy)-3-methoxyphenyl]methyl}-N-[3-(2-fluorophenyl)propyl]cyclobutanamine
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Brazzolotto, X, Pidany, F, Korabecny, J, Cahlikova, L, Nachon, F.
登録日2023-02-06
公開日2023-06-14
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation.
Eur.J.Med.Chem., 252, 2023
1ADO
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BU of 1ado by Molmil
FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE FROM RABBIT MUSCLE
分子名称: 1,3-DIHYDROXYACETONEPHOSPHATE, ALDOLASE, SULFATE ION
著者Blom, N.S, Sygusch, J.
登録日1996-12-02
公開日1997-12-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Product binding and role of the C-terminal region in class I D-fructose 1,6-bisphosphate aldolase.
Nat.Struct.Biol., 4, 1997
1AIA
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BU of 1aia by Molmil
STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING THE PYRIDOXAL-5'-PHOSPHATE BINDING LYSINE RESIDUE
分子名称: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, ASPARTATE AMINOTRANSFERASE
著者Jaeger, J, Jansonius, J.N.
登録日1994-05-10
公開日1994-10-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking the pyridoxal 5'-phosphate-binding lysine residue.
Biochemistry, 34, 1995
5K1I
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BU of 5k1i by Molmil
PDE4 crystal structure in complex with small molecule inhibitor
分子名称: 4-[(5-acetyl-2-ethyl-3-oxo-6-phenyl-2,3-dihydropyridazin-4-yl)amino]benzoic acid, MAGNESIUM ION, ZINC ION, ...
著者Segarra, V, Hernandez, B, Ferrer-Miralles, N, Korndoerfer, I, Aymami, J.
登録日2016-05-18
公開日2016-12-21
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships.
J. Med. Chem., 59, 2016
12AS
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BU of 12as by Molmil
ASPARAGINE SYNTHETASE MUTANT C51A, C315A COMPLEXED WITH L-ASPARAGINE AND AMP
分子名称: ADENOSINE MONOPHOSPHATE, ASPARAGINE, ASPARAGINE SYNTHETASE
著者Nakatsu, T, Kato, H, Oda, J.
登録日1997-12-02
公開日1998-12-30
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of asparagine synthetase reveals a close evolutionary relationship to class II aminoacyl-tRNA synthetase.
Nat.Struct.Biol., 5, 1998

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