156D

REFINED SOLUTION STRUCTURE OF THE DIMERIC QUADRUPLEX FORMED FROM THE OXYTRICHA TELOMERIC OLIGONUCLEOTIDE D(GGGGTTTTGGGG)

Summary for 156D

• Entry DOI: 10.2210/pdb156d/pdb
• Descriptor: DNA (5'-D(*GP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3') (1 entity in total)
• Functional Keywords: dna, quadruplex, oxytricha telomeric oligonucleotide d(ggggttttgggg)
• Total number of polymer chains: 2
• Total formula weight: 7610.92

Authors

Schultze, P.,Smith, F.W.,Feigon, J. (deposition date: 1994-01-17, release date: 1994-04-30, Last modification date: 2024-05-22)

Primary citation

Schultze, P.,Smith, F.W.,Feigon, J.
Refined solution structure of the dimeric quadruplex formed from the Oxytricha telomeric oligonucleotide d(GGGGTTTTGGGG).
Structure, 2:221-233, 1994

PubMed Abstract: Telomeres, the structures at the ends of linear eukaryotic chromosomes, are essential for chromosome replication and stability. The telomeres of the unicellular ciliate Oxytricha contain a 3' single strand overhang composed of two repeats of the telomere repeat sequence d(TTTTGGGG). It has been proposed that oligonucleotides containing this repeat can form DNA quadruplexes via hydrogen bonding of the guanines into quartets. Such structures may be relevant to the biological function of the telomere, and in G-rich sequences elsewhere in the genome.

PubMed: 8069635
DOI: 10.1016/S0969-2126(00)00023-X

Experimental method

SOLUTION NMR