1MTP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1mtp by Molmil](/molmil-images/mine/1mtp) | The X-ray crystal structure of a serpin from a thermophilic prokaryote | Descriptor: | Serine Proteinase Inhibitor (SERPIN), Chain A, Chain B | Authors: | Irving, J.A, Cabrita, L.D, Rossjohn, J, Pike, R.N, Bottomley, S.P, Whisstock, J.C. | Deposit date: | 2002-09-21 | Release date: | 2003-04-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment Structure, 11, 2003
|
|
1XU8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1xu8 by Molmil](/molmil-images/mine/1xu8) | The 2.8 A structure of a tumour suppressing serpin | Descriptor: | Maspin, SULFATE ION | Authors: | Irving, J.A, Law, R.H, Ruzyla, K, Bashtannyk-Puhalovich, T.A, Kim, N, Worrall, D.M, Rossjohn, J, Whisstock, J.C. | Deposit date: | 2004-10-25 | Release date: | 2005-03-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix. J.Biol.Chem., 280, 2005
|
|
2H4R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2h4r by Molmil](/molmil-images/mine/2h4r) | |
6QU9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6qu9 by Molmil](/molmil-images/mine/6qu9) | Fab fragment of an antibody that inhibits polymerisation of alpha-1-antitrypsin | Descriptor: | FAB 4B12 heavy chain, FAB 4B12 light chain, GLYCEROL, ... | Authors: | Jagger, A.M, Heyer-Chauhan, N, Lomas, D.A, Irving, J.A. | Deposit date: | 2019-02-26 | Release date: | 2020-03-18 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The structural basis for Z alpha 1 -antitrypsin polymerization in the liver. Sci Adv, 6, 2020
|
|
8P4U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8p4u by Molmil](/molmil-images/mine/8p4u) | Alpha-1-antitrypsin - Sydney variant (G192C) | Descriptor: | Alpha-1-antitrypsin | Authors: | Kamuda, K, Lomas, D.A, Irving, J.A. | Deposit date: | 2023-05-23 | Release date: | 2024-04-03 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A novel pathological mutant reveals the role of torsional flexibility in the serpin breach in adoption of an aggregation-prone intermediate. Febs J., 291, 2024
|
|
8P4J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8p4j by Molmil](/molmil-images/mine/8p4j) | Alpha-1-antitrypsin - Sydney variant (G192C) | Descriptor: | Alpha-1-antitrypsin | Authors: | Kamuda, K, Lomas, D.A, Irving, J.A. | Deposit date: | 2023-05-22 | Release date: | 2024-04-03 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | A novel pathological mutant reveals the role of torsional flexibility in the serpin breach in adoption of an aggregation-prone intermediate. Febs J., 291, 2024
|
|
8PI2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pi2 by Molmil](/molmil-images/mine/8pi2) | |
2DUT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2dut by Molmil](/molmil-images/mine/2dut) | |
1SNG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1sng by Molmil](/molmil-images/mine/1sng) | Structure of a Thermophilic Serpin in the Native State | Descriptor: | COG4826: Serine protease inhibitor, SULFATE ION | Authors: | Fulton, K.F, Buckle, A.M, Cabrita, L.D, Irving, J.A, Butcher, R.E, Smith, I, Reeve, S, Lesk, A.M, Bottomley, S.P, Rossjohn, J, Whisstock, J.C. | Deposit date: | 2004-03-10 | Release date: | 2004-12-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition. J.Biol.Chem., 280, 2005
|
|
4J1Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4j1y by Molmil](/molmil-images/mine/4j1y) | The X-ray crystal structure of human complement protease C1s zymogen | Descriptor: | Complement C1s subcomponent | Authors: | Perry, A.J, Wijeyewickrema, L.C, Wilmann, P.G, Gunzburg, M.J, D'Andrea, L, Irving, J.A, Pang, S.S, Duncan, R.C, Wilce, J.A, Whisstock, J.C, Pike, R.N. | Deposit date: | 2013-02-03 | Release date: | 2013-04-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6645 Å) | Cite: | A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4. J.Biol.Chem., 288, 2013
|
|
6HX4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6hx4 by Molmil](/molmil-images/mine/6hx4) | Fab fragment of a native monomer-selective antibody in complex with alpha-1-antitrypsin | Descriptor: | Alpha-1-antitrypsin, Fab 1D9 heavy chain, Fab 1D9 light chain | Authors: | Elliston, E.L.K, Miranda, E, Perez, J, Jagger, A.M, Lomas, D.A, Irving, J.A. | Deposit date: | 2018-10-15 | Release date: | 2019-10-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Characterisation of a monoclonal antibody conformationally-selective for native alpha-1-antitrypsin To Be Published
|
|
6I1O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6i1o by Molmil](/molmil-images/mine/6i1o) | Fab fragment of an antibody selective for wild-type alpha-1-antitrypsin | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FAB 2H2 heavy chain, FAB 2H2 light chain, ... | Authors: | Laffranchi, M, Elliston, E.L.K, Miranda, E, Perez, J, Fra, A, Lomas, D.A, Irving, J.A. | Deposit date: | 2018-10-29 | Release date: | 2019-11-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin. JCI Insight, 5, 2020
|
|
6GXX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gxx by Molmil](/molmil-images/mine/6gxx) | Fab fragment of an antibody selective for alpha-1-antitrypsin in the native conformation | Descriptor: | FAB 1D9 heavy chain, FAB 1D9 light chain, MAGNESIUM ION | Authors: | Elliston, E.L.K, Miranda, E, Perez, J, Lomas, D.A, Irving, J.A. | Deposit date: | 2018-06-27 | Release date: | 2019-07-10 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Characterisation of a monoclonal antibody conformationally-selective for native alpha-1-antitrypsin To Be Published
|
|
6I3Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6i3z by Molmil](/molmil-images/mine/6i3z) | Fab fragment of an antibody selective for wild-type alpha-1-antitrypsin in complex with its antigen | Descriptor: | Alpha-1-antitrypsin, Fab 2H2 heavy chain, Fab 2H2 light chain, ... | Authors: | Laffranchi, M, Elliston, E.L.K, Miranda, E, Perez, J, Jagger, A.M, Fra, A, Lomas, D.A, Irving, J.A. | Deposit date: | 2018-11-08 | Release date: | 2019-11-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin. JCI Insight, 5, 2020
|
|
6I4V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6i4v by Molmil](/molmil-images/mine/6i4v) | |
6ROD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6rod by Molmil](/molmil-images/mine/6rod) | |
6IAY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6iay by Molmil](/molmil-images/mine/6iay) | |
6I7U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6i7u by Molmil](/molmil-images/mine/6i7u) | |
1WZ9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1wz9 by Molmil](/molmil-images/mine/1wz9) | The 2.1 A structure of a tumour suppressing serpin | Descriptor: | Maspin precursor, SULFATE ION | Authors: | Law, R.H, Irving, J.A, Buckle, A.M, Ruzyla, K, Buzza, M, Bashtannyk-Puhalovich, T.A, Beddoe, T.C, Kim, N, Worrall, D.M, Bottomley, S.P, Bird, P.I, Rossjohn, J, Whisstock, J.C. | Deposit date: | 2005-03-03 | Release date: | 2005-03-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix. J.Biol.Chem., 280, 2005
|
|
1YXA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yxa by Molmil](/molmil-images/mine/1yxa) | Serpina3n, a murine orthologue of human antichymotrypsin | Descriptor: | serine (or cysteine) proteinase inhibitor, clade A, member 3N | Authors: | Horvath, A.J, Irving, J.A, Law, R.H, Rossjohn, J, Bottomley, S.P, Quinsey, N.S, Pike, R.N, Coughlin, P.B, Whisstock, J.C. | Deposit date: | 2005-02-20 | Release date: | 2005-09-06 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins. J.Biol.Chem., 280, 2005
|
|
2H4Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2h4q by Molmil](/molmil-images/mine/2h4q) | |
2H4P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2h4p by Molmil](/molmil-images/mine/2h4p) | |